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Maternal Iron Deficiency Anemia Affects Postpartum Emotions and Cognition Pelvic inflammatory disease: a family practice perspective Microbiology profile in women with pelvic inflammatory disease in relation to IUD use Epidermiological markers in pelvic inflammatory disease (PID) among the women of reproductive age group Bacterial isolates associated with pelvic inflammatory disease among female patients attending some hospitals in abuja, Nigeria The Key Element Role of Metallophores in the Pathogenicity and Virulence of Staphylococcus aureus: A Review The relationship between serum calprotectin levels and disease activity in patients with subacute thyroiditis. 919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System Gut microbiota: Linking nutrition and perinatal depression The role of gut microbiota and blood metabolites in postpartum depression: A Mendelian randomization analysis. Association between dietary magnesium intake and pelvic inflammatory disease in US women: a cross-sectional study of NHANES Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Kangfuxiaoyan Suppository for Treating Chronic Pelvic Inflammatory Disease Treatment of postpartum depression: Clinical, psychological and pharmacological options A Metabolomics Study of the Volatile Oil from Prunella vulgaris L. On Pelvic Inflammatory Disease Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

Natural favonols: actions, mechanisms, and potential therapeutic utility for various diseases

March 18, 2025

Last Updated: 2024

Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.

Karen Pendergrass

Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.

The review investigated the biological and medicinal importance of flavonols, particularly their roles in disease prevention and treatment. The focus was on their antioxidative properties and their potential therapeutic utility against diabetes, cancer, cardiovascular diseases, and microbial infections.

The key findings highlighted the protective roles of flavonols such as quercetin, myricetin, kaempferol, and fisetin against oxidative damage, their effectiveness in inhibiting tumor growth, improving insulin secretion, and acting as alternatives to conventional antibiotics by blocking viral entry and restricting viral infection.

The study’s greatest implications emphasize flavonols’ potential to significantly reduce the risk of chronic diseases like cancer and coronary diseases, suggesting their integration into dietary strategies and therapeutic approaches. This could lead to developments in how dietary flavonols are recommended for disease prevention and management in clinical practices.

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