Divine Aleru, Microbiome Signatures Research Coordinator

This review details how environmental metal exposures influence menopause onset, symptoms, and OVID-19 outcomes, emphasizing the potential for trace mineral supplementation and the need for monitoring heavy metal and micronutrient status in menopausal women.

This review outlines the evaluation and management of osteoporosis in premenopausal women, emphasizing secondary causes, appropriate MD interpretation, and tailored treatment—highlighting the importance of individualized care and cautious pharmacotherapy in this population.

This review challenges the labeling of hot flashes as mere menopausal symptoms, proposing they signal underlying neurovascular dysregulation linked to chronic disease risk, and calls for new clinical and research approaches.

This study demonstrates significant alterations in gut bacteria, fungi, and metabolites in postmenopausal women with osteoporosis, revealing microbial and metabolic signatures closely linked to bone mineral density and providing a basis for early diagnosis and targeted interventions.

This review elucidates the neuroendocrine and thermoregulatory mechanisms of menopausal hot flashes, evaluating objective measurement and treatment strategies, with a focus on central sympathetic activation and the limited role of the microbiome or estrogen alone in F etiology.

This study identifies distinct gut microbiome and functional gene signatures associated with osteoporosis and osteopenia in postmenopausal women, highlighting key microbial taxa and metabolic pathways that may influence bone health and serve as potential targets for clinical intervention.

Menopause is linked to reduced gut microbiome diversity, loss of beneficial Firmicutes and Roseburia, and increased risk-associated taxa and metabolic pathways. These changes may contribute to higher metabolic and immune disease risk, highlighting the microbiome’s potential as a therapeutic and biomarker target.

Menopause in Latina women is linked to distinctive gut microbiome and estrobolome alterations, resembling those in men, and these microbial changes are associated with increased cardiometabolic risk. The study identifies specific microbiome signatures potentially mediating menopause-related metabolic effects.

Greater fecal microbiome diversity in postmenopausal women correlates with urinary estrogen metabolite profiles linked to lower breast cancer risk. Specific taxa, notably Clostridiales, are associated with beneficial estrogen metabolism signatures.

This study found that menopausal syndrome is linked to gut microbiota dysbiosis, with reduced Bifidobacterium animalis and altered metabolic pathways, suggesting microbiome-targeted interventions may benefit menopausal women.