Divine Aleru, Microbiome Signatures Research Coordinator

A narrative review examining how dietary patterns, nutrients, and gut microbiota impact female fertility, highlighting the Mediterranean diet’s benefits, the risks of Western diets, key micronutrients, and the clinical importance of individualized nutritional care for women planning pregnancy or experiencing infertility.

What was studied?This original research investigated the long-term effects of dietary quercetin supplementation on female fertility and ovarian physiology in mice, with a specific focus on the role of the enzyme transglutaminase 2 (G2). Quercetin, a widely consumed flavonoid supplement, is known for its antioxidant properties, but its effects on female reproductive health remain poorly […]

What was reviewed?This review article examines current evidence on the use of medical-grade honey (GH) as a novel therapy for bacterial vaginosis (V), a prevalent condition among women of reproductive age characterized by a dysbiosis of the vaginal microbiome. V is associated with a reduction in protective, lactic acid-producing lactobacilli and an overgrowth of pathogenic […]

Honey exerts protective effects in reproductive health by modulating oxidative stress, supporting hormonal balance, and selectively inhibiting pathogens while preserving beneficial microbiota, making it a promising adjunct in fertility support, menopause symptom relief, and vulvovaginal candidiasis management.

This review summarizes evidence linking Mediterranean Diet adherence to improved RT outcomes, highlighting modest benefits for clinical pregnancy and live birth rates. Methodological heterogeneity and lack of CTs limit conclusions, underscoring the need for standardized research and mechanistic exploration.

This editorial reviews evidence on metformin for COS-related infertility, highlighting its benefits for ovulation induction, especially in women with longer fertility timelines, and advocating for individualized therapy over restrictive guidelines.

A randomized clinical trial found Nigella sativa plus black pepper significantly improved pregnancy rates and reproductive parameters versus letrozole plus tamoxifen in infertile women with COS, with comparable safety.

This review highlights how dietary patterns, micronutrients, genetics, and the microbiome interact to influence female infertility and RT outcomes, supporting the role of personalized nutrition and microbiome-targeted interventions in reproductive medicine.

This review details how probiotics modulate the human microbiome to support fertility, addressing mechanisms, clinical evidence, and implications for male and female reproductive health, with particular focus on Lactobacillus species and their role in infertility treatment and prevention.

This review details how the reproductive tract microbiome impacts infertility and reproductive outcomes, highlighting the roles of specific microbial taxa, dysbiosis in disease, and potential microbiome-targeted therapies to improve RT success and pregnancy outcomes.