Divine Aleru, Microbiome Signatures Research Coordinator

This review synthesizes evidence on the multifactorial mechanisms underlying endometriosis-associated infertility, emphasizing inflammatory, hormonal, anatomical, and molecular drivers. It highlights advances in non-invasive diagnostics, individualized treatment, and the clinical promise of integrating molecular and microbiome signatures into care protocols for improved fertility outcomes.

This review details the multifactorial pathogenesis of endometriosis-associated infertility, emphasizing molecular, genetic, and inflammatory mechanisms, and evaluates current and emerging treatments, including VF and novel regenerative therapies.

This case report describes a young woman with premature ovarian insufficiency who, despite infertility and diagnostic confirmation of OI, experienced spontaneous conception. The case underscores the unpredictable nature of OI and the need for ongoing investigation into its etiologies, including possible microbiome links.

A large-scale Taiwanese study found that upper and lower genital tract infections, but not comorbidities or bacterial vaginosis, independently increased infertility risk. ID and lower genital tract inflammation showed the strongest associations, emphasizing the critical role of reproductive tract infections in female infertility.

A Nigerian study found only 10% of reproductive-age women recognized the link between ID and infertility, despite high education levels. The findings emphasize the need for improved public health campaigns and highlight the microbial etiology—chiefly Chlamydia trachomatis—behind ID-related infertility.

This review details the polymicrobial pathogenesis of ID, its major microbial culprits—including both classical TIs and vaginal anaerobes—and underscores the high risk of infertility. Early diagnosis, broad-spectrum treatment, and awareness of microbiome shifts are key to reducing reproductive morbidity.

A comprehensive bibliometric analysis of global research trends in polycystic ovary syndrome (COS) and infertility reveals increasing publication rates, evolving research priorities, and key knowledge gaps, with growing emphasis on metabolic and inflammatory mechanisms relevant to microbiome research and clinical practice.

This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and their impact on reproductive outcomes and management strategies.

This study shows women with secondary infertility have persistently altered, less diverse vaginal microbiomes unresponsive to VF hormone stimulation. Increased Atopobium and decreased Lactobacillus may hinder VF success, suggesting microbiome-targeted interventions could benefit infertility care.

Microbiome dysbiosis and elevated miR-21-5p and miR-155-5p levels are strongly linked to unexplained infertility, suggesting their role as biomarkers. Correcting these microbiome imbalances could enhance fertility treatment success rates.