Divine Aleru, Microbiome Signatures Research Coordinator

Polycystic ovary syndrome (COS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

The study evaluates the efficacy of Irosustat, TX140, and compound 1G as alternative treatments for COS, showing improvements in metabolic and hormonal profiles, with promising results on oxidative stress and inflammation markers. These compounds offer potential advantages over current COS therapies like metformin.

This study identifies potential drug targets for COS, focusing on genes involved in insulin resistance and hormone signaling pathways. Findings could help develop more targeted treatments.

This study compared the effects of myo-inositol and metformin on insulin resistance, menstrual cycle regularity, and hyperandrogenism in women with COS. Both therapies were effective, with fewer side effects noted for myo-inositol.

This study explores the use of berberine in combination with other drugs for treating COS, highlighting its effects on insulin resistance, androgen excess, and metabolic dysfunction.

What was studied?This study investigated the potential of repurposing DA-approved drugs to treat Polycystic Ovary Syndrome (COS). Using bioinformatics tools, the authors analyzed protein-protein interactions (PIs) related to COS and explored how certain drugs could interact with these proteins to potentially mitigate the pathogenesis of the disorder. The analysis particularly focused on identifying crucial molecules […]

What was studied?This randomized, double-blind, placebo-controlled clinical trial studied the effects of probiotic supplementation on pancreatic β-cell function and C-reactive protein (RP) levels in women with polycystic ovary syndrome (COS). The aim was to explore how probiotics might influence insulin sensitivity, metabolic parameters, and inflammation markers in COS, which is often associated with insulin resistance, […]

This randomized trial evaluates the effects of synbiotic supplementation on hormonal, inflammatory, and metabolic parameters in women with COS. It shows significant improvements in androgen levels, insulin sensitivity, and inflammation.

This review examines the link between COS and gut microbiota dysbiosis, highlighting how dietary and microbial interventions may improve clinical outcomes. The study underscores the potential of prebiotics, probiotics, and synbiotics as treatments.

This study demonstrates that resistant dextrin supplementation can improve metabolic and endocrine parameters in women with COS, offering a promising alternative to traditional therapies.