Divine Aleru, Microbiome Signatures Research Coordinator

This review proposes a combination of fecal microbiota transplantation (MT) and curcumin as a potential treatment for Polycystic Ovary Syndrome (COS). The hypothesis suggests these therapies could restore gut eubiosis, reduce inflammation, and improve metabolic dysfunction in COS patients.

This study evaluates the therapeutic potential of fecal microbiota transplantation (MT) for treating female reproductive tract diseases, including COS, by restoring microbiota balance.

This systematic review links heavy metal exposure and trace element deficiencies to oxidative stress, inflammation, and hormonal imbalance in COS, with implications for metabolic dysfunction and gut microbiome disruption.

This study links elevated arsenic, cadmium, lead, and mercury levels to oxidative stress and low antioxidant defenses in COS patients, highlighting heavy metal toxicity as a key contributor to endocrine dysfunction and microbiome imbalance.

This case–control study links high copper and low molybdenum levels to metabolic, hormonal, and inflammatory changes in COS. Dietary habits influenced these levels, suggesting potential for targeted nutritional interventions.

This study found that women with COS had elevated cadmium, antimony, lead, and mercury levels, alongside reduced zinc and copper. These imbalances correlated with insulin resistance, oxidative stress, and inflammation, suggesting that metal exposure contributes to COS pathogenesis and potentially alters the gut microbiome.

This study revealed elevated serum copper and zinc, and reduced manganese and lead, in women with COS, suggesting trace element dysregulation may fuel oxidative stress and hormonal imbalance. These imbalances may also impact gut microbiota and insulin resistance.

This study shows women with COS have elevated blood lead and cadmium and reduced magnesium, calcium, and manganese—disrupting hormone levels through oxidative stress and possibly altering gut microbiota.

This meta-analysis confirms that serum copper levels are significantly elevated in women with COS. Copper may drive hormonal imbalance and oxidative stress, and could influence gut microbiota, highlighting its potential as a biomarker and therapeutic target in COS management.

This study identified elevated erythrocyte nickel in obese women with COS and revealed trace element–hormone correlations linked to reproductive dysfunction. These findings point to micronutrient-driven endocrine disruption and potential gut microbiota imbalances in COS.