Divine Aleru, Microbiome Signatures Research Coordinator

This study identifies a strong link between gut microbiota dysbiosis and altered serum metabolites in COS patients. Specific microbial shifts, including elevated Shigella and reduced Roseburia, correlate with lipid and energy metabolism markers, offering insights into COS-related insulin resistance and mood disturbances.

A high-fiber diet combined with acarbose improved hormonal, metabolic, and inflammatory markers in women with COS by remodeling the gut microbiota. Key microbial shifts included increases in Bifidobacterium and reductions in Bacteroides vulgatus, correlating with decreased insulin resistance and hyperandrogenism.

This meta-analysis confirms that women with COS consume significantly less dietary fiber than controls, independent of calorie intake. Reduced fiber may worsen COS via gut dysbiosis and diminished CFA production.

This review highlights how probiotic and synbiotic supplementation improves insulin resistance, inflammation, and androgen levels in obese adolescents with COS. Microbiome modulation offers a promising non-pharmacological therapy.

What was studied?This randomized, double-blinded, placebo-controlled clinical trial investigated the effects of co-supplementation with vitamin D and probiotics on mental health, hormonal profiles, inflammatory markers, and oxidative stress in women with polycystic ovary syndrome (COS). The study tested whether the combination of these two interventions could provide synergistic benefits in a population known to have […]

Women with COS had lower Mediterranean diet adherence and worse metabolic, inflammatory, and hormonal profiles. Poor D adherence correlated with higher testosterone, RP, and OMA-R, suggesting a microbiome-linked dietary influence on COS severity.

A ketogenic diet restored menstrual cycles and improved pregnancy rates in obese women with COS, even without metformin or ovulation induction. Findings suggest D enhances fertility through metabolic and microbiome-linked pathways beyond weight loss.

A Mediterranean/low-carb diet significantly improved insulin resistance, androgen levels, and weight in overweight COS patients. The findings suggest microbiome-mediated metabolic benefits and support clinical adoption of this dietary model over traditional low-fat diets.

What was reviewed?This overview synthesized evidence from eight systematic reviews and meta-analyses investigating the effects of probiotics, prebiotics, and synbiotics on the management of polycystic ovarian syndrome (COS). The reviews collectively evaluated randomized controlled trials (CTs) focusing on metabolic, hormonal, and inflammatory markers to clarify how microbiota-modulating interventions influence COS-related outcomes. The analysis spanned data […]

A 24-week ketogenic diet significantly reduced insulin resistance, free testosterone, and H/SH ratio in women with COS, improving fertility markers. The dietary intervention may influence gut microbiota, enhancing metabolic and hormonal outcomes.