Divine Aleru, Microbiome Signatures Research Coordinator

This study identifies key metabolites altered in premature ovarian insufficiency (OI), including arachidonoyl amide and 18-ETE, which could serve as diagnostic biomarkers. The findings reveal insights into the metabolic disturbances of OI, offering potential therapeutic directions.

This study explores the potential link between serum heavy metal levels and premature ovarian insufficiency. The higher levels of metals like lead and mercury in women with OI suggest environmental toxins may contribute to ovarian dysfunction, though the findings were not statistically significant.

This review highlights the impact of heavy metal-induced oxidative stress on ovarian function, contributing to premature ovarian insufficiency. It discusses the mechanisms by which metals like copper, arsenic, and cadmium induce OS, leading to ovarian damage, and the potential therapeutic role of antioxidants.

Tobacco smoke significantly impacts ovarian function, leading to premature ovarian insufficiency. The review outlines the harmful effects of various tobacco-related toxins, such as nicotine, cadmium, and AHs, and the associated reproductive consequences, including early menopause and reduced fertility.

The review explores the potential of dietary supplements, including probiotics and phytoestrogens, to manage premature ovarian insufficiency (OI) symptoms. It highlights the safety, bioavailability, and efficacy of these nutrients for improving reproductive health and delaying ovarian function decline.

This study identifies dietary habits that influence the risk of Primary Ovarian Insufficiency (OI), finding that high-fat dairy products increase risk while oily fish and pork offer protection, suggesting that dietary interventions could help prevent OI.

The study reveals a distinct gut microbiome profile in women with premature ovarian insufficiency (OI), with altered bacterial populations linked to hormonal changes, suggesting a potential role of the microbiome in OI pathogenesis and management.

The study reveals that women with premature ovarian insufficiency on systemic hormone therapy maintain a Lactobacillus-dominated vaginal microbiome, similar to estrogenized women, though some show signs of bacterial vaginosis, indicating the influence of factors beyond estrogen.

This study identifies significant differences in vaginal microbiota between women with premature ovarian insufficiency (OI) and healthy controls, suggesting that microbial shifts could contribute to ovarian dysfunction and hormone imbalances in OI.

This study identifies significant differences in vaginal microbiota between women with Primary Ovarian Failure (OF) and healthy controls, highlighting the role of Lactobacillus species in reproductive health and suggesting potential microbiota-targeted interventions for OF.