Divine Aleru, Microbiome Signatures Research Coordinator

This study evaluated a Saccharomyces cerevisiae-based probiotic for bacterial vaginosis treatment. The probiotic selectively inhibited V-associated pathogens like G. vaginalis without harming beneficial lactobacilli, offering a microbiome-friendly alternative to antibiotics.

This cross-sectional study identified a strong link between elevated serum lead and cadmium levels and increased risk of bacterial vaginosis. It suggests that heavy metal exposure may disrupt vaginal microbiota stability and immunity, contributing to V susceptibility and pointing to new environmental factors in V prevention strategies.

This study revealed how bacterial vaginosis alters vaginal metabolism, linking specific microbial shifts with distinctive metabolite profiles. It showed that V-associated bacteria drive metabolic changes that increase vaginal pH, disrupt epithelial integrity, and produce characteristic symptoms, offering new diagnostic markers and therapeutic targets.

This review explains how microbial shifts, metabolite production, and immune responses interact in bacterial vaginosis. It highlights the roles of Gardnerella, Atopobium, and other anaerobes in disrupting vaginal health and discusses how their metabolic byproducts and immune modulation drive V symptoms and persistence.

This study used a multi-omic approach to reveal key microbial and metabolic markers of bacterial vaginosis. It identified two distinct symptomatic V metabotypes, each defined by unique microbial and metabolite associations, underscoring the need for metabolomics-informed clinical diagnostics.

This study highlights metabolic interactions between Gardnerella vaginalis and Prevotella bivia, revealing their role in bacterial vaginosis and preterm birth risk. Using MR metabolomics, it identifies acetate as a key metabolite linked to vaginal dysbiosis, offering insights for improving V diagnostics and potential microbiome-targeted interventions.

A nutrient-rich diet lowers bacterial vaginosis (V) risk, while processed foods increase it. This study highlights the importance of dietary choices in vaginal microbiome balance, offering insights for clinicians on how diet influences V risk.

A high glycemic load diet increases bacterial vaginosis (V) risk, while nutrient-rich diets lower it. This study highlights the link between diet quality and vaginal microbiome balance, providing insights for clinicians on how dietary interventions may help prevent V.

A diet high in processed foods and sugar increases bacterial vaginosis (V) risk, while a plant-based diet lowers it. This study highlights the importance of dietary choices in vaginal health, providing insights for clinicians on how nutrition influences the vaginal microbiome.

Higher dietary fat intake increases the risk of bacterial vaginosis (V), while folate, vitamin E, and calcium may lower severe V risk. This study suggests dietary interventions could play a role in managing V, offering insights for clinicians on how nutrition affects vaginal microbiome balance.

The Nugent Score is a standardized Gram stain-based scoring system used to diagnose bacterial vaginosis (V) by assessing key bacterial morphotypes in vaginal samples. With its high specificity, it remains a gold standard in microbiome research, though its complexity and need for trained personnel make it less common in routine clinical practice.

Amsel’s Criteria is a clinically established diagnostic method for bacterial vaginosis, offering a practical and accessible alternative to laboratory-based approaches. It evaluates four key clinical indicators, ensuring timely diagnosis and intervention in outpatient settings.

This study analyzed daily changes in vaginal microbiota before, during, and after V episodes. Findings highlight microbial instability, early dysbiosis markers, and the need for microbiome-focused V treatments.

This study assessed vaginal microbiota in V-positive women using real-time CR. It found reduced Lactobacillus crispatus, biofilm-associated pathogens, and high diagnostic accuracy for molecular testing. Results suggest CR-based diagnostics improve V detection and highlight the need for microbiome-targeted therapies.

This study analyzed vaginal microbiota diversity in women with V using molecular techniques. It identified key V-associated bacteria and emphasized the need for molecular diagnostics and microbiome-targeted therapies.

This study examines vaginal microbiome recovery after metronidazole treatment for V. Findings show delayed microbiota stabilization, L. iners dominance post-treatment, and the need for improved diagnostic tools to predict V recurrence.

This study used high-resolution sequencing to analyze bacterial communities in women with V. Findings reveal distinct microbial associations, diagnostic inconsistencies, and racial differences in V prevalence, highlighting the need for microbiome-targeted therapies and improved diagnostic tools.

This review explores bacterial vaginosis, focusing on microbial imbalances, immune responses, and diagnostic challenges. It highlights the need for microbiome-based treatments and improved diagnostics to reduce recurrence and improve V management.

This study identifies bacterial vaginosis-associated species, improving V diagnostics and treatment strategies through metagenomic sequencing.

This review explores bacterial vaginosis, emphasizing its recurrence, microbial associations, and treatment challenges. It highlights the need for microbiome-based therapies, standardized diagnostic criteria, and potential partner treatment to reduce reinfection. The findings underscore the importance of improved strategies for long-term V management.

This review explores bacterial vaginosis recurrence, emphasizing microbial persistence, reinfection, and partner treatment. It highlights the need for improved therapeutic strategies, including antimicrobial and microbiome-focused approaches, to reduce recurrence and improve long-term cure rates.

This review explores the competing hypotheses behind bacterial vaginosis (V), emphasizing microbial shifts, racial disparities, and sexual transmission. Key findings suggest V may be sexually transmitted and driven by Gardnerella vaginalis biofilms, necessitating novel treatment strategies beyond standard antibiotics. Understanding V pathogenesis is essential for improving prevention and care.

This review explores bacterial vaginosis (V), emphasizing microbial shifts, diagnostic challenges, and treatment strategies. It highlights the role of biofilms, emerging molecular diagnostics, and microbiome-based therapies like probiotics and vaginal microbiota transplantation, advocating for more effective, microbiome-informed approaches to managing V and its recurrence.

This review explores bacterial vaginosis diagnostics, highlighting traditional limitations and emerging molecular solutions. Advances in sequencing, metabolomics, and I-driven analysis offer promising improvements, enhancing diagnostic accuracy and treatment strategies.