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Diagnosis of the menopause: NICE guidance and quality standards Factors affecting the absorption and excretion of lead in the rat Factors associated with age at menarche, menstrual knowledge, and hygiene practices among schoolgirls in Sharjah, UAE Cadmium transport in blood serum Structured Exercise Benefits in Euthyroid Graves’ Disease: Improved Capacity, Fatigue, and Relapse Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging Long-term postmenopausal hormone therapy and endometrial cancer Dietary Intake and Ovarian Cancer Risk: A Systematic Review Assessing Acute and Chronic Risks of Human Exposure to Arsenic Maternal Iron Deficiency Anemia Affects Postpartum Emotions and Cognition Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review Prevalence of hot flushes and night sweats around the world: a systematic review Hormone therapy and the risk of stroke: Perspectives ten years after the Women’s Health Initiative trials Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study Exercise for dysmenorrhoea

Crohn’s Disease

November 3, 2025

Update All Major Updates2025-11-03 13:04:59 Crohn’s Disease majorpublished1

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Last Updated: 2025-11-03

Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.

See full history

Karen Pendergrass

Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.

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Update History

2025-11-03 13:04:59

Crohn's Disease major

published

1
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A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Class)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Family)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Genus)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Kingdom)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Order)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Phylum)
A microbiome signature is defined through a comprehensive approach that integrates differential abundance analysis across multiple datasets, followed by interpretation for biological relevance. This rigorous process ensures that the identified signature is both statistically robust and biologically meaningful. Associations that do not meet statistical significance or lack mechanistic relevance are excluded from the final signature.
Relative Abundance (Species)
Studies