Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Female Infertility

Researched by:

  • Divine Aleru ID
    Divine Aleru

    User avatarI am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.

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July 15, 2025

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (V), COS, Endometriosis, and Pelvic Inflammatory Disease (ID). Microbiome-targeted interventions (BTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

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Researched by:

  • Divine Aleru ID
    Divine Aleru

    User avatarI am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.

    Read More

Last Updated: 2025-07-15

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Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.

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Microbiome Signatures

Overview

Female infertility is a complex and multifactorial condition that affects approximately 10-15% of women of reproductive age globally. It is defined as the inability to conceive after one year of unprotected intercourse, though this rate increases with age, particularly after 35 years.[1] In the United States, around 1 in 8 couples experience infertility, with the female factor contributing to nearly 40-50% of cases. Common causes of female infertility include ovulatory disorders, structural abnormalities of the reproductive organs, and conditions like Polycystic Ovary Syndrome (PCOS), Endometriosis, and Pelvic Inflammatory Disease (PID). Bacterial Vaginosis (BV), which affects 29% of women of reproductive age, is also a significant contributor, as its association with chronic pelvic inflammatory disease and endometritis can lead to infertility.[2] In addition to infections, hormonal imbalances, autoimmune diseases, and environmental factors also contribute to female infertility. Recent studies have also highlighted the crucial role of the microbiome in both the vaginal and gut environments, with disruptions in the microbiome contributing to inflammation, immune system alteration, and infertility.[3][4] With advancing age, the chances of successful conception drop, and fertility treatments like In-Vitro Fertilization (IVF) are often required. The success rates for IVF vary but are generally higher for women under 35, with success rates declining to approximately 10-15% by age 40.[5] Collectively, infertility is a major public health concern, and there is a need for early diagnosis, intervention, and treatment to improve reproductive outcomes, minimize the psychological and emotional burden on affected individuals, and reduce healthcare costs associated with prolonged infertility treatments.

Associated Conditions

Polycystic Ovary Syndrome (PCOS) is a common condition linked to infertility and characterized by hormonal imbalances, including hyperandrogenism and anovulation, which disrupt ovulation and hinder fertility. Women with PCOS are also at risk for insulin resistance and metabolic dysfunction, further complicating their reproductive health.[6] Another significant contributor to infertility is Pelvic Inflammatory Disease (PID), often caused by infections such as Chlamydia trachomatis and Neisseria gonorrhoeae. PID leads to inflammation in the upper reproductive tract, resulting in complications like tubo-ovarian abscesses and fallopian tube damage, which can directly impair fertility.[7] Studies show that chronic PID and repeated infections increase the risk of tubal factor infertility.[8]Endometriosis is another major cause of infertility, affecting nearly 50% of women with the condition.[9] It disrupts ovarian reserve, reduces embryo quality, and alters endometrial receptivity, significantly lowering the chances of conception. The pathophysiology of endometriosis-related infertility is multifactorial, involving chronic inflammation, immune system alterations, and physical disruptions of reproductive organs.[10]Bacterial Vaginosis (BV), characterized by an imbalance in the vaginal microbiome with a reduction in Lactobacillus species and an increase in anaerobic bacteria like Gardnerella vaginalis, is closely associated with infertility. BV can lead to pelvic inflammatory disease and chronic endometritis, further impacting fertility by causing inflammation in the uterus and fallopian tubes.[11]

Causes

The pathogenesis of infertility remains complex and is influenced by a variety of factors. One of the primary theories is infection-mediated damage, where ascending pathogens such as Chlamydia trachomatis and Gardnerella vaginalis induce PID.[12] This inflammation can lead to scarring, tubal occlusion, and damage to reproductive organs, resulting in infertility. While infection is a major contributor to infertility in some cases, many instances remain unexplained, particularly when no overt infection is present. Another theory involves immune modulation by the microbiome. Dysbiosis, which refers to an imbalance in microbial communities, can alter the mucosal immune system.[13] This shift in immune tone may lead to conditions like chronic endometritis, which impairs endometrial receptivity and the chances of successful implantation. A third theory focuses on endocrine disruption, where changes in the microbiome of the gut and reproductive tract can affect hormone metabolism.[15] Some research points to metabolomic effects, where microbial metabolites are absorbed into the bloodstream and may directly impact ovarian function, folliculogenesis, and embryo development.[16] These theories, while promising, still have limitations, as the precise mechanisms linking the microbiome to infertility are not yet fully understood, and much of the evidence remains correlative rather than causal.

Diagnosis

Diagnosis of infertility increasingly incorporates microbiome and metabolomic signatures as promising non-invasive methods. One of the most relevant techniques is microbiome profiling, which uses 16S rRNA sequencing to analyze the vaginal microbiome.[17] This method has shown that a Lactobacillus-dominated microbiota is often associated with better reproductive outcomes, while a dysbiotic microbiome, typically characterized by pathogens like Gardnerella vaginalis and Atopobium vaginae, is linked to infertility.[18] The gut microbiome also plays a role in infertility diagnosis. Studies using Mendelian randomization have identified specific gut microbiota, such as Faecalibacterium, which are associated with increased risk of reproductive tract inflammation and infertility.[19][20] In addition to microbiome analyses, recent advancements in miRNA biomarkers have shown potential. For example, elevated levels of miR-21-5p and miR-155-5p in vaginal and rectal samples have been linked to infertility caused by microbiome-induced inflammation.[21] These promising diagnostic approaches offer the potential for early detection of infertility risk and for tailoring interventions aimed at restoring microbial balance to improve fertility outcomes.

Primer

A fundamental understanding of female infertility requires a solid grasp of how the microbiome intersects with reproductive health. In the female reproductive system, the microbiome predominantly resides in the vaginal and uterine environments. It is typically dominated by beneficial Lactobacillus species, which contribute to an acidic environment that prevents pathogen overgrowth and supports immune function.[22] However, when this microbial balance is disrupted it has been linked to infertility through mechanisms such as inflammation and immune system alterations.[23] For instance, dysbiosis in the vaginal microbiome, characterized by an overgrowth of pathogens like Gardnerella vaginalis, has been associated with pelvic inflammatory disease and endometriosis, both of which can compromise fertility.[24] Recent studies have revealed the presence of microbiomes in the upper reproductive tract, such as the uterus and Fallopian tubes, which were previously considered sterile. [25]These microbial communities are thought to influence reproductive health by modulating the immune response and hormone metabolism, further complicating the role of the microbiome in fertility. The gut microbiome plays a role in modulating systemic inflammation and metabolic processes that can impact the reproductive system. Understanding these microbiome–reproductive system interactions is essential for developing targeted therapies, such as probiotics or other microbiome-targeted interventions, to restore microbial balance and improve fertility outcomes.

Metallomic Signatures

Heavy metals such as lead (Pb), cadmium (Cd), and arsenic (As) are significant environmental pollutants that have been implicated in female infertility. These metals can accumulate in the human body through various sources, including contaminated food, water, air, and occupational exposures.[26] The toxic effects of these metals on the reproductive system are profound, as they disrupt several biological processes crucial for fertility. For example, lead has been associated with menstrual cycle disturbances, hormonal imbalances, and reduced ovarian function.[27] Cadmium, a known endocrine disruptor, impacts ovarian follicle development, induces oxidative stress, and disrupts hormonal regulation, while arsenic exposure can lead to oxidative damage and affect oocyte maturation.[28][29] The cumulative impact of these metals is often seen in impaired fertility, with a higher risk of conception delays, miscarriage, and reduced pregnancy success rates. Epidemiological studies, including those based on NHANES data, have demonstrated that even low levels of exposure to these metals are associated with increased infertility risks.

What is the metallomic of Female Infertility?

Lead

Lead (Pb) is a toxic heavy metal that has been linked to various reproductive issues in women, including infertility and miscarriage. Even low levels of lead exposure can negatively impact fertility, disrupting the menstrual cycle, reducing ovarian function, and impairing the production of reproductive hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).[30] Lead exposure can also affect the development of ovarian follicles, leading to suboptimal oocyte quality and poor implantation outcomes.[31] Studies have shown that lead can accumulate in the blood and tissues, including the ovaries, where it impairs follicular development and ovulation.[32] It is commonly found in contaminated drinking water, industrial workplaces, tobacco smoke, and even in certain cosmetics. The impact of lead on fertility has been observed in both animal models and human epidemiological studies, with evidence suggesting a dose-dependent relationship between blood lead levels and infertility risk.

Cadmium

Cadmium (Cd) is another heavy metal that significantly contributes to female infertility, particularly through its ability to disrupt ovarian function and oocyte quality.[33] Exposure to cadmium can lead to ovarian follicle damage, reduced ovarian reserve, and disrupted hormone regulation, specifically affecting estrogen and progesterone levels. It can induce oxidative stress, leading to cellular damage and inflammation in the reproductive tract. Cadmium is classified as an endocrine disruptor and is known to accumulate in the body, particularly in tissues such as the kidneys and liver, but also in the ovaries.[34][35] The metal has been linked to delayed conception, miscarriage, and infertility due to its toxic effects on the ovary and fallopian tubes. Major sources of cadmium exposure include tobacco smoke, industrial and environmental pollution, and contaminated food and water.[36] Epidemiological studies have found that women with higher levels of cadmium in their blood or urine are more likely to experience infertility. Even low levels of cadmium exposure have been associated with reduced fertility in some studies.[37]

Arsenic

Arsenic (As) exposure has been shown to disrupt ovarian function and impair the process of oocyte maturation.[38] It also induces oxidative stress and DNA damage, which can lead to abnormal embryo development and implantation failure.[39] Long-term exposure to arsenic, particularly through contaminated drinking water, has been associated with increased levels of reproductive toxicity.[40] Studies have found that arsenic exposure disrupts the endocrine system, affecting the release of hormones essential for reproductive health. Research indicates that arsenic exposure can increase the risk of infertility, with higher arsenic concentrations in urine and blood correlating with a greater likelihood of fertility issues.[41] Women who live in areas with high environmental arsenic levels or work in industries where arsenic is prevalent are at higher risk of these reproductive disturbances.

Mercury

Mercury (Hg) is a highly toxic heavy metal that can significantly affect female fertility through its impact on the endocrine system and reproductive organs. Mercury exposure has been linked to reduced egg quality, impaired fertilization, and developmental issues during pregnancy.[42] It can disrupt the hormonal regulation of the menstrual cycle and the ovarian function necessary for proper ovulation. Mercury induces oxidative stress, which damages ovarian tissue and disrupts the balance of hormones such as estrogen and progesterone, both of which are crucial for maintaining fertility.[43] Major sources of mercury exposure include contaminated fish, dental amalgams, and industrial pollution.[44] Studies have shown that even low levels of mercury exposure can be harmful to fertility, with higher concentrations found in the blood and urine of women with fertility issues. The detrimental effects of mercury on reproductive health are often cumulative, leading to long-term fertility problems.[45] Animal studies have provided evidence of mercury’s toxic effects on the ovaries, while human studies have corroborated these findings, linking mercury exposure to menstrual disturbances and delayed pregnancy,[46]

Metabolomic Signatures

Metabolomic profiling has become a crucial tool in understanding female infertility, as it offers insights into the biochemical environment of the follicular fluid (FF) and its role in oocyte development and fertilization. Studies have shown that women with infertility often exhibit altered metabolic signatures in FF, including imbalances in antioxidants, energy metabolites, and markers of oxidative stress.[47] Key compounds such as lactate, ammonia, and creatinine are found in higher concentrations in the FF of infertile women, while glucose and amino acids, which are vital for oocyte quality, are often reduced.[48] Oxidative stress markers like malondialdehyde (MDA) and reduced glutathione (GSH) are altered, reflecting the negative impact of oxidative damage on oocyte health and IVF success rates.[49] These metabolic changes are particularly evident in conditions such as polycystic ovary syndrome (PCOS), endometriosis, and age-related reduced ovarian reserve, where distinct metabolic profiles could help predict IVF outcomes.[50] Environmental factors, such as exposure to endocrine-disrupting chemicals like bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP), contribute to infertility by disrupting hormonal regulation and increasing oxidative stress, further complicating fertility issues.[51] The cumulative effects of these pollutants, which interfere with metabolic processes critical for reproductive health, have been shown to significantly increase infertility risk.

Microbiome Signature: Female Infertility

Interventions

Microbiome-targeted interventions (MBTIs) are emerging as an essential element in the treatment of infertility, especially in addressing conditions like Bacterial Vaginosis (BV), Polycystic Ovary Syndrome (PCOS), Endometriosis, and Pelvic Inflammatory Disease (PID). These conditions have been increasingly associated with microbial dysbiosis, a disruption in the balance of the vaginal and uterine microbiomes, which can lead to infertility. MBTIs aim to restore healthy microbial communities, promote optimal immune responses, and prevent microbial overgrowth, which can be pivotal in enhancing fertility outcomes. In light of these developments, MBTIs are gaining significant attention in clinical research as potential preventative and therapeutic tools for improving reproductive health.

InterventionMechanismMBTI Status
Medical-Grade Honey (MGH)MGH creates an osmotic environment that inhibits bacterial growth, reduces inflammation, and promotes the growth of Lactobacillus species, the key beneficial bacteria that maintain vaginal health.[52] Honey also exhibits anti-inflammatory and antioxidant properties, which support a healthy vaginal microbiome. These combined effects make it effective for preventing recurrent BV and improving fertility outcomes by restoring a balanced microbiome.[53]Experimental
ProbioticsProbiotics, particularly Lactobacillus strains, promote vaginal microbiome restoration by enhancing lactic acid production, which lowers vaginal pH and suppresses harmful pathogens.[54] They also produce bacteriocins, natural antibiotics that fight harmful microorganisms.[55] By restoring a Lactobacillus-dominant microbiome, probiotics enhance fertility and support healthy reproductive tract environments.[56]Promising Candidate
MetforminMetformin indirectly supports fertility in women with Polycystic Ovary Syndrome (PCOS) by improving insulin sensitivity. Insulin resistance is common in PCOS and negatively affects ovarian function. By improving insulin regulation, metformin helps restore gut microbiota balance, which influences hormonal regulation.[57]Promising Candidate
Vaginal Microbiota Transplantation (VMT)VMT introduces healthy, donor-derived microbiota into the vaginal environment. This transplant restores a balanced microbiome, reducing inflammation and promoting healthy reproductive function. By replenishing Lactobacillus, it prevents the overgrowth of harmful bacteria, supporting fertility.[58][59]Experimental
Mediterranean DietThe Mediterranean Diet has systemic effects on the gut microbiome, which influences female reproductive health. Rich in polyunsaturated fatty acids (PUFAs), antioxidants, and fiber, this diet promotes healthy gut microbiota that regulates immune responses, reduces systemic inflammation, and improves hormonal regulation.[60] These changes in the gut microbiome help support ovarian function, improve endometrial receptivity, and optimize the chances of successful conception.[61]Promising Candidate
Dietary Fiber (Guar Gum)Dietary fiber, specifically Guar Gum, functions as a prebiotic to promote the growth of beneficial gut bacteria.The effects of guar gum positively influences endometrial receptivity, ovarian reserve, and menstrual regularity, all of which are critical factors for fertility. Guar Gum’s ability to reduce gut dysbiosis makes it a potential therapy for improving fertility outcomes, especially in women undergoing ART.[62]Under Investigation

STOPs

The STOPs initiative encourages the critical reassessment of common everyday practices that may quietly undermine reproductive health and contribute to female infertility. Many widely accepted habits, from dietary choices to herbal remedies, are rarely questioned, yet they can significantly impact hormonal balance, ovulation, and the delicate interplay of factors necessary for conception. One example is the regular consumption of hibiscus tea. Often promoted for its antioxidant and blood pressure-lowering effects, hibiscus also contains natural phytoestrogens, plant compounds that can mimic or disrupt normal estrogen function.[63] Emerging research suggests that frequent intake may influence menstrual cycle length, progesterone levels, and ovulatory patterns, potentially lowering the chances of successful conception in some women.

STOP Microbiome ImpactInfertilityRisk
Hibiscus rosa-sinensisAlter gut and vaginal microbiome composition through phytoestrogen activity, though evidence is still emerging.[64][65][66]Disrupts hormonal balance (estrogen/progesterone), may interfere with ovulation and menstrual cycle regularity, potentially reducing conception rates.[67]

FAQs

What emerging treatments are available for infertility linked to microbiome and metabolic disruption?

In recent years, treatments for female infertility have begun to move beyond traditional hormone therapies and surgical interventions, incorporating approaches that target the microbiome and metabolic health. One emerging area involves the use of probiotics and dietary interventions to restore a healthy balance of microbes in the vaginal and gut ecosystems. These therapies aim to reduce inflammation and improve conditions for conception by re-establishing microbial communities that support reproductive function. Additionally, antioxidant therapy is being explored as a way to counteract the oxidative stress commonly found in the follicular fluid of infertile women, potentially improving oocyte quality and embryo development. Personalized IVF protocols are also being developed based on a patient’s specific microbiome and metabolic profile, allowing for more targeted and effective treatment strategies. These new interventions offer hope for addressing cases of unexplained infertility and represent a significant shift toward precision medicine in reproductive healthcare.

What tools are used to diagnose infertility related to microbial and metabolic factors?

Modern diagnostics for female infertility are increasingly incorporating advanced techniques that focus on the microbiome and metabolome. One of the most promising tools is 16S rRNA gene sequencing, which allows clinicians to profile the vaginal microbiome and identify bacterial imbalances associated with poor fertility outcomes. Research has shown that a microbiome rich in Lactobacillus is generally favorable, while a shift toward anaerobic bacteria correlates with inflammation and reproductive dysfunction. In addition to microbiome profiling, emerging studies are using metabolomic analysis to examine follicular fluid and other reproductive tissues for biomarkers related to oxidative stress and metabolic imbalance. Elevated levels of certain microRNAs, such as miR-21-5p and miR-155-5p, have also been linked to infertility and are being explored as non-invasive diagnostic indicators. These innovative approaches not only enhance early detection of fertility issues but also provide insights into personalized treatment strategies that target microbial and metabolic imbalances.

Can infertility be unexplained even after testing, and what might be the reason?

Yes, a significant number of infertility cases are classified as “unexplained,” even after standard evaluations of ovulation, hormone levels, sperm quality, and anatomical assessments. This diagnosis can be frustrating for patients, as it offers little clarity on the underlying cause. However, growing research suggests that unexplained infertility may often be linked to subtle disruptions that conventional tests are not designed to detect. These include microbial imbalances in the vaginal or uterine microbiome, low-grade inflammation, immune system dysregulation, and metabolic disturbances within the reproductive environment. Emerging fields like microbiome and metabolomic profiling are beginning to uncover these hidden contributors. In such cases, the absence of overt pathology does not imply that there is no issue, but rather that our current diagnostic tools may not yet be sophisticated enough to fully capture the complexities of reproductive biology. Understanding these emerging factors offers hope for more accurate diagnoses and effective, individualized treatments in the future.

Research Feed

Causal Effects of Gut Microbiota on Female Reproductive Tract Inflammation and Infertility: A Mendelian Randomization Study
December 13, 2023
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility
July 15, 2023
/
Infertility
Infertility

Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study
November 14, 2024
/
Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Microbiota and Human Reproduction: The Case of Female Infertility
May 3, 2020
/
Infertility
Infertility

Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Endometrial microbiota composition is associated with reproductive outcome in infertile patients
January 4, 2022
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Differential Composition of Vaginal Microbiome Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility
December 10, 2019
/
Infertility
Infertility

Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Human genital tracts microbiota: dysbiosis crucial for infertility
January 3, 2022
/
Infertility
Infertility

Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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The Role of Genital Tract Microbiome in Fertility: A Systematic Review
December 24, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Properties of Infertility Microbiome in a Review Article
March 9, 2025
/

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Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? 
July 22, 2022
/

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Alterations of Vaginal Microbiota in Women With Infertility and Chlamydia trachomatis Infection
August 3, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study.
June 5, 2020
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Potential biomarkers of infertility associated with microbiome imbalances
May 6, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery
July 14, 2020
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

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Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease
March 3, 2021
/
Bacterial Vaginosis
Bacterial Vaginosis

Did you know?
Bacterial vaginosis (BV) increases the risk of acquiring HIV by up to 60% in women due to the disruption of the protective vaginal microbiome and the resulting inflammation that facilitates the virus’s entry.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID)

Did you know?

Bacterial vaginosis (BV) is the most common vaginal disorder linked to an increased risk of PID and that restoring Lactobacillus-dominant flora reduces this risk?

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The relationship between polycystic ovary syndrome and infertility: a bibliometric analysis.

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Pelvic inflammatory disease and infertility
April 29, 2023
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID)

Did you know?

Bacterial vaginosis (BV) is the most common vaginal disorder linked to an increased risk of PID and that restoring Lactobacillus-dominant flora reduces this risk?

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Relationships between female infertility and female genital infections and pelvic inflammatory disease
April 9, 2018
/
Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID)

Did you know?

Bacterial vaginosis (BV) is the most common vaginal disorder linked to an increased risk of PID and that restoring Lactobacillus-dominant flora reduces this risk?

Bacterial Vaginosis
Bacterial Vaginosis

Did you know?
Bacterial vaginosis (BV) increases the risk of acquiring HIV by up to 60% in women due to the disruption of the protective vaginal microbiome and the resulting inflammation that facilitates the virus’s entry.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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POI: Premature Ovarian Insufficiency/Pregnancy or Infertility?
January 9, 2013
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

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Perception prevalence of the relationship between PID and infertility amongst women of reproductive age: A Nigerian study
February 6, 2023
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID)

Did you know?

Bacterial vaginosis (BV) is the most common vaginal disorder linked to an increased risk of PID and that restoring Lactobacillus-dominant flora reduces this risk?

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Endometriosis and Infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility
December 5, 2012
/
Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Endometriosis-associated infertility: From pathophysiology to tailored treatment
October 26, 2022
/
Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics
February 11, 2023
/

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Metabolic risk factors and fertility disorders: A narrative review of the female perspective
October 1, 2021
/
Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS)

Did you know?
Women with PCOS produce more than double the amount of anti-Müllerian hormone (AMH) compared to women without PCOS—so much so that some researchers have proposed renaming the condition “AMH syndrome.”

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization
August 14, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS)

Did you know?
Women with PCOS produce more than double the amount of anti-Müllerian hormone (AMH) compared to women without PCOS—so much so that some researchers have proposed renaming the condition “AMH syndrome.”

Endometriosis
Endometriosis

Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Association between co-exposure to phenols and phthalates mixture and infertility risk in women
September 2, 2022
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Association between heavy metals exposure and infertility among American women aged 20-44 years: A cross-sectional analysis from 2013 to 2018 NHANES data
February 14, 2023
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility
November 9, 2022
/
Infertility
Infertility

Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Relationship between risk factors for infertility in women and lead, cadmium, and arsenic blood levels: a cross-sectional study from Taiwan
December 9, 2015
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Female Fertility and Environmental Pollution
November 26, 2020
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS)

Did you know?
Women with PCOS produce more than double the amount of anti-Müllerian hormone (AMH) compared to women without PCOS—so much so that some researchers have proposed renaming the condition “AMH syndrome.”

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Female Infertility Associated with Blood Lead and Cadmium Levels
March 10, 2020
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility
October 6, 2022
/
Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS)

Did you know?
Women with PCOS produce more than double the amount of anti-Müllerian hormone (AMH) compared to women without PCOS—so much so that some researchers have proposed renaming the condition “AMH syndrome.”

Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
June 18, 2021
/

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Reproductive tract microbiome and therapeutics of infertility
April 25, 2023
/

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Probiotics and the envisaged role in treating human infertility
October 21, 2020
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Comparative Effect of Nigella Sativa+ Black Pepper and Letrozole + Tamoxifen on Female Infertility in Women with Polycystic Ovarian Syndrome: A Randomized Clinical Trial
April 12, 2023
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Metformin in the Treatment of Infertility in PCOS: An Alternative Perspective
June 11, 2008
/

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The Role of the Mediterranean Diet in Assisted Reproduction: A Literature Review
August 27, 2024
/

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Protective Roles of Honey in Reproductive Health: A Review
June 1, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis
April 17, 2024
/
Bacterial Vaginosis
Bacterial Vaginosis

Did you know?
Bacterial vaginosis (BV) increases the risk of acquiring HIV by up to 60% in women due to the disruption of the protective vaginal microbiome and the resulting inflammation that facilitates the virus’s entry.

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Effects of dietary quercetin on female fertility in mice: implication of transglutaminase 2
January 5, 2015
/
Bacterial Vaginosis
Bacterial Vaginosis

Did you know?
Bacterial vaginosis (BV) increases the risk of acquiring HIV by up to 60% in women due to the disruption of the protective vaginal microbiome and the resulting inflammation that facilitates the virus’s entry.

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Female Fertility and the Nutritional Approach: The Most Essential Aspects
June 17, 2021
/
Female Infertility
Female Infertility

Did you know?

Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).

Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.

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Update History

2025-06-25 12:45:56

Female Infertility major

published

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Probiotics

Probiotics are live microorganisms that offer significant health benefits when administered in adequate amounts. They primarily work by modulating the gut microbiome, supporting a balanced microbial ecosystem. Probiotics have been shown to improve gut health, modulate immune responses, and even influence metabolic and mental health disorders. With growing evidence supporting their therapeutic potential, probiotics are increasingly recognized for their role in treating conditions like irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), and even mental health conditions like depression and anxiety through their impact on the gut-brain axis.

Microbiome-Targeted Interventions (MBTIs)

Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.

Microbiome-Targeted Interventions (MBTIs)

Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

STOPs

A STOP (Suggested Termination Of Practices) is a recommendation that advocates for the discontinuation of certain medical interventions, treatments, or practices based on emerging evidence indicating that these may be ineffective, harmful, or counterproductive in the management of specific conditions.

STOP: Routine Consumption of Hibiscus Tea/Juice and Its Potential Impact on Female Fertility

Routine consumption of hibiscus tea or juice may affect female fertility by disrupting ovulation, implantation, and hormonal balance. Women trying to conceive or undergoing fertility treatments should be cautious and discuss herbal intake with their healthcare provider to avoid unintended reproductive consequences.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Infertility

Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Infertility

Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Infertility

Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Infertility

Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Pelvic Inflammatory Disease (PID)

Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Endometriosis

Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Infertility

Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Bacterial Vaginosis

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

Women’s Health

Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Female Infertility

Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.

References

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  4. Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery.. Zhao C, Wei Z, Yang J, Zhang J, Yu C, Yang A, Zhang M, Zhang L, Wang Y, Mu X, Heng X, Yang H, Gai Z, Wang X, Zhang L.. (mSystems. 2020 Jul 14;5(4):e00450-20.)
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  7. Pelvic inflammatory disease and infertility.. Hunt S, Vollenhoven B.. (Aust J Gen Pract. 2023;52(4):215-218.)
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Walker MH, Tobler KJ.

Female Infertility

[Updated 2022 Dec 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

Tomaiuolo R, Veneruso I, Cariati F, D’Argenio V.

Microbiota and Human Reproduction: The Case of Female Infertility.

High-Throughput. 2020; 9(2):12.

Read Review

Zhao C, Wei Z, Yang J, Zhang J, Yu C, Yang A, Zhang M, Zhang L, Wang Y, Mu X, Heng X, Yang H, Gai Z, Wang X, Zhang L.

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery.

mSystems. 2020 Jul 14;5(4):e00450-20.

Read Review

Pierce, Nicolea; Mocanu, Edgara,b.

Female age and assisted reproductive technology

Global Reproductive Health 3(2):p e9, June 2018. | DOI:

Zhuang S, Jing C, Yu L, Ji L, Liu W, Hu X.

The relationship between polycystic ovary syndrome and infertility: a bibliometric analysis.

Ann Transl Med. 2022 Mar;10(6):318

Read Review

Hunt S, Vollenhoven B.

Pelvic inflammatory disease and infertility.

Aust J Gen Pract. 2023;52(4):215-218.

Read Review

Bonavina, G., & Taylor, H. S. (2022).

Endometriosis-associated infertility: From pathophysiology to tailored treatment.

Frontiers in Endocrinology, 13, 1020827.

Read Review

Vitale SG, Ferrari F, Ciebiera M, Zgliczyńska M, Rapisarda AMC, Vecchio GM, Pino A, Angelico G, Knafel A, Riemma G, De Franciscis P, Cianci S.

The Role of Genital Tract Microbiome in Fertility: A Systematic Review

Int J Mol Sci. 2021 Dec 24;23(1):180

Read Review

Venneri, M.A., Franceschini, E., Sciarra, F. et al.

Human genital tracts microbiota: dysbiosis crucial for infertility.

J Endocrinol Invest 45, 1151–1160 (2022).

Read Review

Azpiroz MA, Orguilia L, Palacio MI, Malpartida A, Mayol S, Mor G, Gutiérrez G.

Potential biomarkers of infertility associated with microbiome imbalances.

Am J Reprod Immunol. 2021 Oct;86(4):e13438

Read Review

Azpiroz MA, Orguilia L, Palacio MI, Malpartida A, Mayol S, Mor G, Gutiérrez G.

Potential biomarkers of infertility associated with microbiome imbalances.

Am J Reprod Immunol. 2021 Oct;86(4):e13438

Read Review

Westerman R, Kuhnt AK.

Metabolic risk factors and fertility disorders: A narrative review of the female perspective

Reproductive BioMedicine and Society Online. 2022;14:66-74

Read Review

Elahi Z, Mokhtaryan M, Mahmoodi S, Shahroodian S, Darbandi T, Ghasemi F, Ghanavati R, Darbandi A.

All Properties of Infertility Microbiome in a Review Article

J Clin Lab Anal. 2025 Mar 9:e25158

Read Review

Zhao C, Wei Z, Yang J, Zhang J, Yu C, Yang A, Zhang M, Zhang L, Wang Y, Mu X, Heng X, Yang H, Gai Z, Wang X, Zhang L.

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery.

mSystems. 2020 Jul 14;5(4):e00450-20.

Read Review

Feng, Z., Chen, J., Zhang, Y., Jia, C., Du, L., & Chen, D. (2023).

Gut microbiota, female reproductive tract, inflammation, infertility, Mendelian randomization [Research article]. Research Square.

13 December 2023, PREPRINT (Version 1) available at Research Square

Read Review

Azpiroz MA, Orguilia L, Palacio MI, Malpartida A, Mayol S, Mor G, Gutiérrez G.

Potential biomarkers of infertility associated with microbiome imbalances.

Am J Reprod Immunol. 2021 Oct;86(4):e13438

Read Review

Chen X, Lu Y, Chen T, Li R

The Female Vaginal Microbiome in Health and Bacterial Vaginosis

Front Cell Infect Microbiol. 2021 Apr 7;11:631972

Read Review

Vitale SG, Ferrari F, Ciebiera M, Zgliczyńska M, Rapisarda AMC, Vecchio GM, Pino A, Angelico G, Knafel A, Riemma G, De Franciscis P, Cianci S.

The Role of Genital Tract Microbiome in Fertility: A Systematic Review

Int J Mol Sci. 2021 Dec 24;23(1):180

Read Review

Trifanescu OG, Trifanescu RA, Mitrica RI, Bran DM, Serbanescu GL, Valcauan L, Marinescu SA, Gales LN, Tanase BC, Anghel RM.

The Female Reproductive Tract Microbiome and Cancerogenesis: A Review Story of Bacteria, Hormones, and Disease.

Diagnostics (Basel). 2023 Feb 24;13(5):877.

Lee S, Min JY, Min KB.

Female infertility associated with blood lead and cadmium levels.

Int J Environ Res Public Health. 2020;17(5):1794.

Read Review

Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

Read Review

Manouchehri A, Shokri S, Pirhadi M, Karimi M, Abbaszadeh S, Mirzaei G, Bahmani M.

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility.

JBRA Assisted Reproduction. 2022;26(4):627-630

Read Review

Lee S, Min JY, Min KB.

Female infertility associated with blood lead and cadmium levels.

Int J Environ Res Public Health. 2020;17(5):1794.

Read Review

Osowski A, Fedoniuk L, Bilyk Y, Fedchyshyn O, Sas M, Kramar S, Lomakina Y, Fik V, Chorniy S, Wojtkiewicz J.

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries.

Toxics. 2023 Sep 10;11(9):769

Manouchehri A, Shokri S, Pirhadi M, Karimi M, Abbaszadeh S, Mirzaei G, Bahmani M.

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility.

JBRA Assisted Reproduction. 2022;26(4):627-630

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Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

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Manouchehri A, Shokri S, Pirhadi M, Karimi M, Abbaszadeh S, Mirzaei G, Bahmani M.

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility.

JBRA Assisted Reproduction. 2022;26(4):627-630

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Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

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Alrashed, M., Tabassum, H., Almuhareb, N., Almutlaq, N., Alamro, W., Alanazi, S. T., Alenazi, F. K., Alahmed, L. B., Al Abudahash, M. M., & Alenzi, N. D. (2021).

Assessment of DNA damage in relation to heavy metal induced oxidative stress in females with recurrent pregnancy loss (RPL).

Saudi Journal of Biological Sciences, 28(9), 5403-5407.

Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

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Zargari, F., Rahaman, M. S., KazemPour, R., & Hajirostamlou, M. (2022).

Arsenic, Oxidative Stress and Reproductive System.

Journal of Xenobiotics, 12(3), 214.

Bjørklund, G., Chirumbolo, S., Dadar, M., Pivina, L., Lindh, U., Butnariu, M., & Aaseth, J. (2019).

Mercury exposure and its effects on fertility and pregnancy outcome.

Basic & Clinical Pharmacology & Toxicology, 125(4), 317-327.

Massányi, P., Massányi, M., Madeddu, R., Stawarz, R., & Lukáč, N. (2020).

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.

Toxics, 8(4), 94.

Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

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Canipari R, De Santis L, Cecconi S.

Female fertility and environmental pollution.

Int J Environ Res Public Health. 2020;17(23):8802.

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Lee S, Min JY, Min KB.

Female infertility associated with blood lead and cadmium levels.

Int J Environ Res Public Health. 2020;17(5):1794.

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Lazzarino G, Pallisco R, Bilotta G, Listorti I, Mangione R, Saab MW, Caruso G, Amorini AM, Brundo MV, Lazzarino G, et al.

Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization.

Int J Mol Sci. 2021;22(16):8735.

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Chen, Y., Yang, J., & Zhang, L. (2023).

The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy.

Antioxidants, 12(12), 2117.

Huang, Y., Cheng, Y., Zhang, M., Xia, Y., Chen, X., Xian, Y., Lin, D., Xie, S., & Guo, X. (2023).

Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization.

Journal of Ovarian Research, 16, 206.

Chen, Y., Yang, J., & Zhang, L. (2023).

The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy.

Antioxidants, 12(12), 2117.

Zhan, W., Yang, H., Zhang, J., & Chen, Q. (2022).

Association between co-exposure to phenols and phthalates mixture and infertility risk in women.

Environmental Research, 215, 114244.

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Zaid SSM, Ruslee SS, Mokhtar MH.

Protective Roles of Honey in Reproductive Health: A Review.

Molecules. 2021;26(11):3322.

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Lardenoije CMJG, van Riel SJJM, Peters LJF, Wassen MMLH, Cremers NAJ.

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis.

Antibiotics. 2024;13(4):368.

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Younis N, Mahasneh A.

Probiotics and the envisaged role in treating human infertility.

Middle East Fertility Society Journal. 2020;25:33.

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Younis N, Mahasneh A.

Probiotics and the envisaged role in treating human infertility.

Middle East Fertility Society Journal. 2020;25:33.

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Bhattacharya K, Dutta S, Sengupta P, Bagchi S.

Reproductive tract microbiome and therapeutics of infertility.

Middle East Fertil Soc J. 2023;28:11

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Meng, Y., Sun, J., & Zhang, G. (2024).

Vaginal microbiota transplantation is a truly opulent and promising edge: Fully grasp its potential.

Frontiers in Cellular and Infection Microbiology, 14, 1280636.

Skoracka K, Ratajczak AE, Rychter AM, Dobrowolska A, Krela-Kaźmierczak I.

Female fertility and the nutritional approach: The most essential aspects.

Adv Nutr. 2021;12(6):2372–2386.

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Baroutis D, Kalampokas T, Katsianou E, Psarris A, Daskalakis G, Panoulis K, Eleftheriades M.

The Role of the Mediterranean Diet in Assisted Reproduction: A Literature Review.

Nutrients. 2024;16(16):2807.

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Komiya S, Naito Y, Okada H, Matsuo Y, Hirota K, Takagi T, Mizushima K, Inoue R, Abe A, Morimoto Y.

Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study.

J Clin Biochem Nutr. 2020 Jul;67(1):105-111

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Campbell, D., Bates, S., & Hickmon, A. (2023).

Hibiscus Tea, Hormone Balance, and Thrombosis: A Case Report.

Integrative Medicine: A Clinician's Journal, 22(2), 40.

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Song SD, Acharya KD, Zhu JE, Deveney CM, Walther-Antonio MRS, Tetel MJ, Chia N.

Daily vaginal microbiota fluctuations associated with natural hormonal cycle, contraceptives, diet, and exercise.

mSphere. 2020;5(4):e00593-20.

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Maeng, L. Y., & Beumer, A. (2023).

Never fear, the gut bacteria are here: Estrogen and gut microbiome-brain axis interactions in fear extinction.

International Journal of Psychophysiology, 189, 66-75.

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Upadhyaya, A., Green, A., & Peiris, M. (2022).

Association between sex hormone levels and gut microbiota composition and diversity – A Systematic Review.

Journal of Clinical Gastroenterology, 56(5), 384.

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Campbell, D., Bates, S., & Hickmon, A. (2023).

Hibiscus Tea, Hormone Balance, and Thrombosis: A Case Report.

Integrative Medicine: A Clinician's Journal, 22(2), 40.

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