Osteoporosis affects one in three women over 50. Estrogen decline during menopause accelerates bone loss, making weight-bearing exercises, calcium, and vitamin D essential for maintaining bone health. Early intervention can reduce fracture risk, and the gut microbiome may play a role in improving bone density.
Did You Know?
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and RT offer effective management strategies.
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Divine Aleru
I am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Divine Aleru
I am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
Overview
Menopause is a natural biological event marking the permanent cessation of menstruation, which occurs after 12 consecutive months without a period, usually between the ages of 45 and 56.[1] This transition results from the loss of ovarian follicles, leading to a decrease in the production of key hormones, particularly estrogen and progesterone.[2] Estrogen’s decline impacts numerous bodily systems, leading to a range of symptoms, including hot flashes, night sweats, vaginal dryness, mood swings, sleep disturbances, and cognitive changes.[3] The period before menopause, known as perimenopause, is characterized by irregular menstrual cycles, fluctuating hormone levels, and vasomotor symptoms, which may last for several years. The menopausal transition marks the end of reproductive capacity, but the health implications can persist well beyond menopause, as women can spend up to one-third of their lives in the postmenopausal period.[4] The hormonal changes associated with menopause are well-documented. Still, the broader impacts on various organ systems, including the gut, urinary tract, and skin, are increasingly being explored through research on the microbiome.[5]
Associated Conditions
Menopause is linked to various health conditions that significantly impact women’s quality of life.[6] Osteoporosis is one of the most common conditions, as the decline in estrogen accelerates bone resorption, leading to decreased bone mineral density (BMD) and an increased risk of fractures.[7] Cardiovascular disease (CVD) is also a significant concern, as the protective effects of estrogen on the cardiovascular system diminish, increasing the risk of heart disease and stroke.[8] Additionally, musculoskeletal disorders such as osteoarthritis and sarcopenia (muscle loss) are prevalent, contributing to disability and reduced mobility in postmenopausal women.[9] Cognitive decline, particularly Alzheimer’s disease, becomes more prominent as estrogen loss may accelerate neurodegenerative processes. Depression is another major issue, often linked to hormonal fluctuations during menopause, while vasomotor symptoms such as hot flashes and night sweats, though distressing, also correlate with an increased risk of cardiovascular events.[10][11] Moreover, sleep disturbances, such as insomnia and sleep apnea, are common, negatively affecting overall health. Lastly, migraines and chronic respiratory diseases like COPD also become more prevalent postmenopause, adding to the health challenges women face during this life stage.[12]
Causes
Menopause is a process that primarily occurs due to the depletion of ovarian follicles, leading to a decrease in estrogen and progesterone production. This decline disrupts the hypothalamic-pituitary-ovarian axis, which regulates the menstrual cycle, and ultimately results in the cessation of menstruation.[13] While the basic cause of menopause, ovarian aging, has been well established, a range of factors can influence the timing and onset of menopause. Genetic predisposition plays a significant role, with research indicating that women whose mothers experienced early menopause are more likely to undergo the transition at a younger age.[14] Environmental and lifestyle factors, such as smoking, body mass index (BMI), physical activity, and stress, are also known to affect the timing of menopause. Smoking, for example, has been consistently linked to earlier menopause, while higher BMI tends to delay its onset.[15][16] Socioeconomic factors, including education level and occupation, have been associated with later menopause, potentially due to differences in healthcare access, nutrition, and overall lifestyle.[17] Hormonal changes, particularly the decline in estrogen, are not the sole contributors to the menopause experience. There is growing evidence suggesting that shifts in the microbiome, particularly in the vaginal and gut microbiota, may also influence the severity of menopause symptoms and contribute to menopause-related health risks.[18] Dysbiosis, or microbial imbalance, resulting from hormonal changes may exacerbate symptoms such as vaginal dryness, urinary tract infections, and gastrointestinal issues. These microbiome shifts, in conjunction with genetic and environmental factors, provide a more complex understanding of menopause beyond just the hormonal decline.[19]
Diagnosis
The diagnosis of menopause is primarily clinical, determined by the cessation of menstrual periods for 12 consecutive months. In women aged 45 and older, menopause is diagnosed based on symptoms alone, without the need for laboratory tests.[20] Hormone levels (FSH, estrogen) are occasionally measured in women aged 40-45, but their reliability is limited due to fluctuations during the perimenopausal period.[21] Women who have undergone hysterectomy may be diagnosed with menopause based solely on the absence of menstrual periods. Microbiome signatures are increasingly being explored as diagnostic tools for menopause-related conditions.[22][23] Studies have investigated microbial changes in the vaginal, gut, and urinary microbiomes during menopause, with a particular focus on dysbiosis as a potential contributor to common symptoms such as vaginal dryness, urinary tract infections, and gastrointestinal issues.[24][25]
Primer
Menopause involves significant hormonal shifts, notably a decline in estrogen, profoundly affecting the vaginal and gut microbiomes.[26] Reduced estrogen decreases beneficial vaginal Lactobacillus populations, increasing pH and susceptibility to infections and genitourinary syndrome symptoms.[27] Similarly, estrogen decline alters gut microbiome composition and diversity, increasing risks for cardiovascular and metabolic diseases.[28] The estrobolome, a subset of gut microbes, is essential in metabolizing estrogen; disruption of this balance during menopause further exacerbates symptoms and associated chronic disease risks.[29] Understanding microbiome-estrogen interactions could thus inform better menopause symptom management and long-term health strategies.
Metallomic Signatures
Exposure to heavy metals such as arsenic, cadmium, lead, and mercury has been increasingly recognized as an important factor influencing menopausal timing and hormonal profiles in midlife women. High levels of these metals are associated with fertility disorders, endocrine dysregulation, and earlier onset of menopause.[30] In particular, arsenic and lead have been linked with significantly earlier natural menopause; for instance, higher urinary concentrations of arsenic and lead have been associated with menopause occurring up to nearly one year earlier compared to women with lower exposures. These metals can disrupt sex hormone levels by reducing circulating estradiol (E2) and increasing follicle-stimulating hormone (FSH), which contributes to ovarian aging.[31] Cadmium and mercury similarly alter hormone levels, with cadmium notably associated with increased sex hormone-binding globulin (SHBG) concentrations, influencing free hormone availability.[32] Heavy metals have been found to interact with menopausal status and exacerbate health risks, including metabolic disturbances and cardiovascular conditions. Collectively, these suggest that heavy metal exposure during midlife significantly contributes to menopause-related endocrine and metabolic disruptions, underscoring the importance of assessing and mitigating environmental metal exposure in menopausal women.[33]
Metabolomic Signatures
Menopause induces substantial shifts in the metabolome, which profoundly influences women’s metabolic health. Estrogen significantly regulates lipid and amino acid metabolism, and its reduction during menopause results in proatherogenic lipid alterations, including increased concentrations of LDL cholesterol, very-low-density lipoprotein triglycerides, and apolipoprotein B (apoB), which elevates cardiovascular disease risks.[34][35] Estrogen deficiency is also implicated in disturbed fatty acid metabolism, including elevated circulating levels of saturated and monounsaturated fatty acids, as well as specific changes in omega-7 and omega-9 fatty acid profiles, potentially exacerbating metabolic syndrome and insulin resistance in postmenopausal women.[36] Importantly, estrogen modulates the metabolism of charged metabolites, particularly amino acids; menopausal transition has been linked to increased levels of branched-chain amino acids like leucine and isoleucine, which are known markers for insulin resistance, obesity, and cardiovascular conditions. Menopause-related estrogen decline disrupts the metabolic pathways involving the tricarboxylic acid (TCA) cycle and urea cycle, leading to altered citrate, glycine, and homocysteine metabolism.[37] These metabolic shifts underscore estrogen’s critical role in maintaining systemic metabolic homeostasis and highlight how its deficiency during menopause contributes significantly to increased risks for metabolic disorders, cardiovascular disease, and osteoporosis in postmenopausal women.
Microbiome Signature: Menopause
Interventions
Microbiome-targeted interventions (MBTIs) for menopause focus on correcting microbial imbalances linked to menopausal symptoms and hormonal shifts. By addressing dysbiosis in the gut, vaginal, and urinary microbiomes, these interventions aim to alleviate common menopause symptoms like hot flashes, mood changes, and metabolic disruptions. MBTIs are gaining attention as a potential therapeutic approach to improve overall health and manage menopause-related conditions, offering a new, microbiome-centered strategy for enhancing women’s well-being during this transition.
Interventions | Mechanisms of Action | MBTI Status |
---|---|---|
Prebiotic Supplementation | Prebiotics enhance the growth of estrogen-metabolizing bacteria like Bifidobacterium and Lactobacillus, improving estrogen metabolism and alleviating menopausal symptoms like hot flashes.[38] | Promising Candidate |
Ketogenic Diet | Alters gut microbiome composition by promoting beneficial microbes, improving insulin sensitivity and reducing inflammation, which are critical for managing menopausal symptoms.[39] | Promising Candidate |
Intermittent Fasting (IF) | IF enhances gut microbiome diversity, reducing inflammation and improving metabolic health, which could alleviate metabolic disturbances in postmenopausal women.[40][41] | Under Investigation |
Phytoestrogens | By improving estrogen balance, phytoestrogens have been shown to reduce the frequency and severity of hot flashes and other menopausal symptoms.[42] | Experimental |
Dietary Fiber and Polyphenols | Soy isoflavones, through dietary fibers and fermented soy products, improve gut health, estrogen metabolism, and cardiovascular health in postmenopausal women.[43][44] | Experimental |
Probiotic Supplementation | Probiotics such as Lactobacillus strains help regulate vaginal and intestinal microbiota, improving immunity and alleviating menopausal symptoms, particularly vaginal dryness and infections.[45][46] | Under Investigation |
Combination of Black Cohosh and Rhodiola | The combination of Actaea racemosa (Black Cohosh) and Rhodiola rosea improves menopausal symptom relief, including hot flashes and psychological symptoms like anxiety.[47][48][49] | Promising Candidate |
Menopausal Hormone Therapy (MHT) | Hormonal therapy using estrogen and progestogen aims to alleviate common menopausal symptoms such as hot flashes, sleep disturbances, and prevent bone loss. It may also improve cardiovascular health.[50][51] | Validated |
Vaginal Microbiota Transplantation (VMT) | VMT involves transplanting vaginal microbiota to restore a healthy microbial environment, potentially reducing infections and alleviating vaginal dryness and irritation associated with menopause.[52] | Experimental |
FAQs
What are the most common symptoms of menopause?
What are the most common symptoms of menopause?
Menopause is associated with a wide range of symptoms, which vary in severity among women. The most common symptoms include hot flashes, night sweats, irregular periods, and vaginal dryness. Hot flashes—sudden feelings of heat that may last a few minutes and are often accompanied by sweating—are particularly common and disruptive, often leading to sleep disturbances. Night sweats, the nighttime counterpart to hot flashes, can cause significant sleep disruption and result in daytime fatigue. Hormonal changes can also affect mood, leading to irritability, anxiety, and depression. Cognitive changes, often referred to as “brain fog,” can include difficulty concentrating, memory lapses, and slower processing speed. Changes in libido are also frequent, with many women experiencing a decrease in sexual desire or comfort. Other physical symptoms include weight gain, particularly around the abdomen, and a higher risk of osteoporosis due to the decline in estrogen. Menopause-related symptoms typically begin around age 45-55, but the onset and duration vary. Managing these symptoms often requires a combination of lifestyle changes, dietary adjustments, and, in some cases, hormone replacement therapy (HRT) or other treatments.
What role does hormone replacement therapy (HRT) play in managing menopausal symptoms, and is it right for me?
What role does hormone replacement therapy (HRT) play in managing menopausal symptoms, and is it right for me?
Hormone replacement therapy (HRT) is often recommended to treat moderate to severe menopausal symptoms like hot flashes, night sweats, vaginal dryness, and mood swings. HRT works by replenishing estrogen and, in some cases, progesterone, which decline during menopause. While HRT is effective for many women, it may not be suitable for everyone, especially those with a history of certain cancers, blood clots, or cardiovascular diseases. It is essential to consult with a healthcare provider to weigh the benefits against potential risks. For some women, non-hormonal treatments like lifestyle changes, dietary modifications, or medications may be preferable.
Can the food I eat help with menopause symptoms?
Can the food I eat help with menopause symptoms?
Diet plays a crucial role in managing menopause symptoms and maintaining overall health during this transitional phase. A well-balanced, nutrient-rich diet can help alleviate common symptoms like hot flashes, weight gain, and mood swings. For instance, foods rich in phytoestrogens, such as soy, flaxseeds, and sesame seeds, contain plant-based compounds that mimic estrogen in the body, potentially helping to regulate hormonal fluctuations and reduce symptoms like hot flashes and vaginal dryness. Omega-3 fatty acids, found in fatty fish like salmon and walnuts, can help reduce inflammation, improve heart health, and alleviate mood disturbances. Additionally, a high-fiber diet can support gut health, improve digestion, and potentially reduce the risk of conditions like osteoporosis and heart disease, which are common in postmenopausal women. It is also beneficial to reduce the intake of caffeine, alcohol, and processed foods, which can exacerbate symptoms like hot flashes and disrupt sleep. Hydration, particularly through water and herbal teas, is essential for managing dehydration and reducing bloating. Lastly, vitamin D and calcium-rich foods like dairy products, leafy greens, and fortified plant milks are important for maintaining bone health during menopause.
Research Feed
Diagnosis of the menopause: NICE guidance and quality standards
June 29, 2017
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
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Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome
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Onset of natural menopause in African American women
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Connecting microbiome and menopause for healthy ageing
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Menopausal shift on women’s health and microbial niches
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Spotlight on the gut microbiome in menopause: current insights
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Socioeconomic and Lifestyle Factors Affecting Age at Natural Menopause: Global Systematic Review
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The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia.
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Menopausal hot flashes: mechanisms, endocrinology, treatment.
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Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis
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What’s in a name: are menopausal ‘hot flashes’ a symptom of menopause or a manifestation of neurovascular dysregulation?
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Premenopausal Bone Health: Osteoporosis in Premenopausal Women
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Study on gut microbiota and metabolomics in postmenopausal women
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The relationship between menopausal syndrome and gut microbes
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Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women
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Menopause Alters Gut Microbiome and Increases Cardiometabolic Risk in Hispanic Women
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Compositional and functional features of the female premenopausal and postmenopausal gut microbiota
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A metabolic view on menopause and ageing
August 21, 2014
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Cardiovascular Health •
Cardiovascular Health
Did you know?
Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) is strongly linked to cardiovascular disease, potentially influencing atherosclerosis more than cholesterol, making the gut microbiome a key therapeutic target.
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Menopause modulates the circulating metabolome: Evidence from a prospective cohort study
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Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women
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Menopause-Induced Metabolic Shifts: Implications for Cardiovascular and Metabolic Risk
October 10, 2021
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Cardiovascular Health •
Cardiovascular Health
Did you know?
Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) is strongly linked to cardiovascular disease, potentially influencing atherosclerosis more than cholesterol, making the gut microbiome a key therapeutic target.
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Interaction of metals, menopause and COVID-19: A review of the literature
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Urinary metals and metal mixtures and timing of natural menopause in midlife women
July 24, 2021
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Metals •
Metals
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Exposure to heavy metals and hormone levels in midlife women
January 15, 2023
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Metals •
Metals
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Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
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Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator
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Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms
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Black cohosh (Cimicifuga spp.) for menopausal symptoms.
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Drugs for the treatment of menopausal symptoms.
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The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?
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Complementary and Alternative Medicine for Menopause
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Health disorders in menopausal women: microbiome alterations, associated problems, and possible treatments
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A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome
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Ketogenic Diet as a Possible Non-pharmacological Therapy in Main Endocrine Diseases of the Female Reproductive System
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Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk in Postmenopausal Women
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Intermittent Fasting and Weight Management at Menopause
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The impact of intermittent fasting on gut microbiota: a systematic review of human studies
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Microbiome-Targeted Interventions (MBTIs)
Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.
Probiotics
Probiotics are live microorganisms that offer significant health benefits when administered in adequate amounts. They primarily work by modulating the gut microbiome, supporting a balanced microbial ecosystem. Probiotics have been shown to improve gut health, modulate immune responses, and even influence metabolic and mental health disorders. With growing evidence supporting their therapeutic potential, probiotics are increasingly recognized for their role in treating conditions like irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), and even mental health conditions like depression and anxiety through their impact on the gut-brain axis.
Vaginal Microbiome Transplant (VMT)
Vaginal Microbiome Transplant (VMT) involves transferring healthy vaginal flora from a donor to a recipient to treat conditions like recurrent bacterial vaginosis. It aims to restore balance in the vaginal microbiome, potentially offering a non-pharmacological treatment option for persistent gynecological disorders.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Cardiovascular Health
Recent research has revealed that specific gut microbiota-derived metabolites are strongly linked to cardiovascular disease risk—potentially influencing atherosclerosis development more than traditional risk factors like cholesterol levels. This highlights the gut microbiome as a novel therapeutic target for cardiovascular interventions.
Trimethylamine N-Oxide (TMAO)
TMAO is a metabolite formed when gut bacteria convert dietary nutrients like choline and L-carnitine into trimethylamine (TMA), which is then oxidized in the liver to TMAO. This compound is linked to cardiovascular disease, as it promotes atherosclerosis, thrombosis, and inflammation, highlighting the crucial role of gut microbiota in influencing heart health.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Cardiovascular Health
Recent research has revealed that specific gut microbiota-derived metabolites are strongly linked to cardiovascular disease risk—potentially influencing atherosclerosis development more than traditional risk factors like cholesterol levels. This highlights the gut microbiome as a novel therapeutic target for cardiovascular interventions.
Trimethylamine N-Oxide (TMAO)
TMAO is a metabolite formed when gut bacteria convert dietary nutrients like choline and L-carnitine into trimethylamine (TMA), which is then oxidized in the liver to TMAO. This compound is linked to cardiovascular disease, as it promotes atherosclerosis, thrombosis, and inflammation, highlighting the crucial role of gut microbiota in influencing heart health.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
References
- Menopause. [Updated 2023 Dec 21].. Peacock K, Carlson K, Ketvertis KM.. (In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Menopausal shift on women’s health and microbial niches.. Nieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A.. (npj Women's Health. 2025;3:3)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Menopausal shift on women’s health and microbial niches.. Nieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A.. (npj Women's Health. 2025;3:3)
- Health issues for menopausal women: the top 11 conditions have common solutions.. van Dijk GM, Kavousi M, Troup J, Franco OH.. (Maturitas. 2015 Jan;80(1):24-30.)
- Premenopausal Bone Health: Osteoporosis in Premenopausal Women.. ABRAHAM, A., COHEN, A., & SHANE, E. (2013).. (Clinical Obstetrics and Gynecology, 56(4), 722.)
- Spotlight on the gut microbiome in menopause: current insights.. Peters BA, Santoro N, Kaplan RC, Qi Q.. (Int J Womens Health. 2022;14:1059–1072.)
- Health issues for menopausal women: the top 11 conditions have common solutions.. van Dijk GM, Kavousi M, Troup J, Franco OH.. (Maturitas. 2015 Jan;80(1):24-30.)
- Health issues for menopausal women: the top 11 conditions have common solutions.. van Dijk GM, Kavousi M, Troup J, Franco OH.. (Maturitas. 2015 Jan;80(1):24-30.)
- What’s in a name: are menopausal ‘hot flashes’ a symptom of menopause or a manifestation of neurovascular dysregulation?. Miller VM, Kling JM, Files JA, Joyner MJ, Kapoor E, Moyer AM, Rocca WA, Faubion SS.. (Menopause. 2018;25(6):700–703)
- Connecting microbiome and menopause for healthy ageing.. Pączek P, Herbst-Kralovetz MM.. (Nat Microbiol. 2022 Mar;7(3):354-358.)
- Onset of natural menopause in African American women.. Palmer JR, Rosenberg L, Wise LA, Horton NJ, Adams-Campbell LL.. (Am J Public Health. 2003;93(2):299-306.)
- Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.. Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.. (mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.)
- Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents.. Schoenaker DAJM, Jackson CA, Rowlands JV, Mishra GD.. (Int J Epidemiol. 2014;43(5):1542–1562.)
- Onset of natural menopause in African American women.. Palmer JR, Rosenberg L, Wise LA, Horton NJ, Adams-Campbell LL.. (Am J Public Health. 2003;93(2):299-306.)
- Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents.. Schoenaker DAJM, Jackson CA, Rowlands JV, Mishra GD.. (Int J Epidemiol. 2014;43(5):1542–1562.)
- Compositional and functional features of the female premenopausal and postmenopausal gut microbiota.. Zhao H, Chen J, Li X, Sun Q, Qin P, Wang Q.. (FEBS Lett. 2019 Sep;593(18):2655-2664.)
- Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.. Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.. (mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.)
- Diagnosis of the menopause: NICE guidance and quality standards.. Davies M, Sarri G, Lumsden MA.. (Ann Clin Biochem. 2017;54(5):516-518.)
- Diagnosis of the menopause: NICE guidance and quality standards.. Davies M, Sarri G, Lumsden MA.. (Ann Clin Biochem. 2017;54(5):516-518.)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.. Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.. (mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Spotlight on the gut microbiome in menopause: current insights.. Peters BA, Santoro N, Kaplan RC, Qi Q.. (Int J Womens Health. 2022;14:1059–1072.)
- Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.. Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.. (mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.. Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.. (mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.)
- The relationship between menopausal syndrome and gut microbes.. Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y.. (BMC Women's Health. 2022;22:437)
- Interaction of Metals, Menopause and COVID-19-A Review of the Literature.. Męcik-Kronenberg T, Kuć A, Kubik-Machura D, Kościelecka K, Radko L.. (Biology (Basel). 2023 Feb 22;12(3):350)
- Interaction of Metals, Menopause and COVID-19-A Review of the Literature.. Męcik-Kronenberg T, Kuć A, Kubik-Machura D, Kościelecka K, Radko L.. (Biology (Basel). 2023 Feb 22;12(3):350)
- Exposure to heavy metals and hormone levels in midlife women: The Study of Women’s Health Across the Nation (SWAN).. Wang X, Ding N, Harlow SD, Randolph JF Jr, Mukherjee B, Gold EB, Park SK.. (Environ Pollut. 2023 Jan 15;317:120740.)
- Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation.. Wang X, Ding N, Harlow SD, Randolph JF Jr, Mukherjee B, Gold EB, Park SK.. (Environ Int. 2021 Dec;157:106781.)
- Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.. Ko SH, Kim HS.. (Nutrients. 2020 Jan 13;12(1):202)
- Menopause modulates the circulating metabolome: evidence from a prospective cohort study.. Karppinen JE, Törmäkangas T, Kujala UM, Sipilä S, Laukkanen J, Aukee P, Kovanen V, Laakkonen EK.. (Eur J Prev Cardiol. 2022 Aug 5;29(10):1448-1459.)
- A metabolic view on menopause and ageing.. Auro, K., Joensuu, A., Fischer, K. et al.. (Nat Commun 5, 4708 (2014).)
- Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study.. Watanabe, K., Iida, M., Harada, S., Kato, S., Kuwabara, K., Kurihara, A., Takeuchi, A., Sugiyama, D., Okamura, T., Suzuki, A., Amano, K., Hirayama, A., Sugimoto, M., Tomita, M., Kobayashi, Y., Banno, K., Aoki, D., & Takebayashi, T. (2022).. (Maturitas, 155, 54–62.)
- The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?. Liaquat M, Minihane AM, Vauzour D, Pontifex MG.. (Post Reprod Health. 2025;31(2):105-114.)
- Ketogenic Diet as a Possible Non-pharmacological Therapy in Main Endocrine Diseases of the Female Reproductive System: A Practical Guide for Nutritionists.. Camajani, E., Feraco, A., Verde, L., Moriconi, E., Marchetti, M., Colao, A., Caprio, M., Muscogiuri, G., & Barrea, L. (2023).. (Current Obesity Reports, 12(3), 231.)
- Intermittent Fasting and Weight Management at Menopause.. Garg R, Chetan R, Jyothi GS, Agrawal P, Gupta P.. (J Midlife Health. 2025;16(1):14-18.)
- The impact of intermittent fasting on gut microbiota: a systematic review of human studies.. Paukkonen I, Törrönen E-N, Lok J, Schwab U, El-Nezami H.. (Front Nutr. 2024;11:1342787.)
- Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause.. Echeverria V, Echeverria F, Barreto GE, Echeverría J, Mendoza C.. (Front Pharmacol. 2021;12:644103.)
- Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk in Postmenopausal Women: A Dietary Trial.. Sánchez-Martínez, L., González-Barrio, R., García-Alonso, J., Mena, P., & Periago, J. (2024).. (Antioxidants, 13(8), 973.)
- Complement Ther Med. 2023;79:103002.. Kahleova H, Holtz DN, Strom N, et al.. (A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome.)
- The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?. Liaquat M, Minihane AM, Vauzour D, Pontifex MG.. (Post Reprod Health. 2025;31(2):105-114.)
- Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.. Park MG, Cho S, Oh MM.. (Diagnostics. 2023;13(6):1193.)
- Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study. Pkhaladze L, Davidova N, Khomasuridze A, Shengelia R, Panossian AG.. (Pharmaceuticals (Basel). 2020;13(5):102)
- Black cohosh (Cimicifuga spp.) for menopausal symptoms.. Leach MJ, Moore V.. (Cochrane Database Syst Rev. 2012;9:CD007244.)
- Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator.. Gerbarg PL, Brown RP.. (Phytomedicine. 2016;000:1-7.)
- Connecting microbiome and menopause for healthy ageing.. Pączek P, Herbst-Kralovetz MM.. (Nat Microbiol. 2022 Mar;7(3):354-358.)
- Spotlight on the gut microbiome in menopause: current insights.. Peters BA, Santoro N, Kaplan RC, Qi Q.. (Int J Womens Health. 2022;14:1059–1072.)
- Connecting microbiome and menopause for healthy ageing.. Pączek P, Herbst-Kralovetz MM.. (Nat Microbiol. 2022 Mar;7(3):354-358.)
Peacock K, Carlson K, Ketvertis KM.
Menopause. [Updated 2023 Dec 21].In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
Park MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewNieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A.
Menopausal shift on women’s health and microbial niches.npj Women's Health. 2025;3:3
Read ReviewPark MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewNieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A.
Menopausal shift on women’s health and microbial niches.npj Women's Health. 2025;3:3
Read Reviewvan Dijk GM, Kavousi M, Troup J, Franco OH.
Health issues for menopausal women: the top 11 conditions have common solutions.Maturitas. 2015 Jan;80(1):24-30.
ABRAHAM, A., COHEN, A., & SHANE, E. (2013).
Premenopausal Bone Health: Osteoporosis in Premenopausal Women.Clinical Obstetrics and Gynecology, 56(4), 722.
Read ReviewPeters BA, Santoro N, Kaplan RC, Qi Q.
Spotlight on the gut microbiome in menopause: current insights.Int J Womens Health. 2022;14:1059–1072.
Read Reviewvan Dijk GM, Kavousi M, Troup J, Franco OH.
Health issues for menopausal women: the top 11 conditions have common solutions.Maturitas. 2015 Jan;80(1):24-30.
van Dijk GM, Kavousi M, Troup J, Franco OH.
Health issues for menopausal women: the top 11 conditions have common solutions.Maturitas. 2015 Jan;80(1):24-30.
Miller VM, Kling JM, Files JA, Joyner MJ, Kapoor E, Moyer AM, Rocca WA, Faubion SS.
What’s in a name: are menopausal ‘hot flashes’ a symptom of menopause or a manifestation of neurovascular dysregulation?Menopause. 2018;25(6):700–703
Read ReviewPączek P, Herbst-Kralovetz MM.
Connecting microbiome and menopause for healthy ageing.Nat Microbiol. 2022 Mar;7(3):354-358.
Read ReviewPalmer JR, Rosenberg L, Wise LA, Horton NJ, Adams-Campbell LL.
Onset of natural menopause in African American women.Am J Public Health. 2003;93(2):299-306.
Read ReviewPeters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.
Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.
Read ReviewSchoenaker DAJM, Jackson CA, Rowlands JV, Mishra GD.
Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents.Int J Epidemiol. 2014;43(5):1542–1562.
Read ReviewPalmer JR, Rosenberg L, Wise LA, Horton NJ, Adams-Campbell LL.
Onset of natural menopause in African American women.Am J Public Health. 2003;93(2):299-306.
Read ReviewSchoenaker DAJM, Jackson CA, Rowlands JV, Mishra GD.
Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents.Int J Epidemiol. 2014;43(5):1542–1562.
Read ReviewZhao H, Chen J, Li X, Sun Q, Qin P, Wang Q.
Compositional and functional features of the female premenopausal and postmenopausal gut microbiota.FEBS Lett. 2019 Sep;593(18):2655-2664.
Read ReviewPeters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.
Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.
Read ReviewDavies M, Sarri G, Lumsden MA.
Diagnosis of the menopause: NICE guidance and quality standards.Ann Clin Biochem. 2017;54(5):516-518.
Read ReviewDavies M, Sarri G, Lumsden MA.
Diagnosis of the menopause: NICE guidance and quality standards.Ann Clin Biochem. 2017;54(5):516-518.
Read ReviewPark MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewPeters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.
Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.
Read ReviewPark MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewPeters BA, Santoro N, Kaplan RC, Qi Q.
Spotlight on the gut microbiome in menopause: current insights.Int J Womens Health. 2022;14:1059–1072.
Read ReviewPeters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.
Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.
Read ReviewPark MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewPeters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC.
Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos.mSystems. 2022 Jun 28;7(3):e0027322. Epub 2022 Apr 13.
Read ReviewLiu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y.
The relationship between menopausal syndrome and gut microbes.BMC Women's Health. 2022;22:437
Read ReviewMęcik-Kronenberg T, Kuć A, Kubik-Machura D, Kościelecka K, Radko L.
Interaction of Metals, Menopause and COVID-19-A Review of the Literature.Biology (Basel). 2023 Feb 22;12(3):350
Read ReviewMęcik-Kronenberg T, Kuć A, Kubik-Machura D, Kościelecka K, Radko L.
Interaction of Metals, Menopause and COVID-19-A Review of the Literature.Biology (Basel). 2023 Feb 22;12(3):350
Read ReviewWang X, Ding N, Harlow SD, Randolph JF Jr, Mukherjee B, Gold EB, Park SK.
Exposure to heavy metals and hormone levels in midlife women: The Study of Women’s Health Across the Nation (SWAN).Environ Pollut. 2023 Jan 15;317:120740.
Read ReviewWang X, Ding N, Harlow SD, Randolph JF Jr, Mukherjee B, Gold EB, Park SK.
Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation.Environ Int. 2021 Dec;157:106781.
Read ReviewKo SH, Kim HS.
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.Nutrients. 2020 Jan 13;12(1):202
Read ReviewKarppinen JE, Törmäkangas T, Kujala UM, Sipilä S, Laukkanen J, Aukee P, Kovanen V, Laakkonen EK.
Menopause modulates the circulating metabolome: evidence from a prospective cohort study.Eur J Prev Cardiol. 2022 Aug 5;29(10):1448-1459.
Read ReviewAuro, K., Joensuu, A., Fischer, K. et al.
A metabolic view on menopause and ageing.Nat Commun 5, 4708 (2014).
Read ReviewWatanabe, K., Iida, M., Harada, S., Kato, S., Kuwabara, K., Kurihara, A., Takeuchi, A., Sugiyama, D., Okamura, T., Suzuki, A., Amano, K., Hirayama, A., Sugimoto, M., Tomita, M., Kobayashi, Y., Banno, K., Aoki, D., & Takebayashi, T. (2022).
Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study.Maturitas, 155, 54–62.
Read ReviewLiaquat M, Minihane AM, Vauzour D, Pontifex MG.
The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?Post Reprod Health. 2025;31(2):105-114.
Read ReviewCamajani, E., Feraco, A., Verde, L., Moriconi, E., Marchetti, M., Colao, A., Caprio, M., Muscogiuri, G., & Barrea, L. (2023).
Ketogenic Diet as a Possible Non-pharmacological Therapy in Main Endocrine Diseases of the Female Reproductive System: A Practical Guide for Nutritionists.Current Obesity Reports, 12(3), 231.
Read ReviewGarg R, Chetan R, Jyothi GS, Agrawal P, Gupta P.
Intermittent Fasting and Weight Management at Menopause.J Midlife Health. 2025;16(1):14-18.
Read ReviewPaukkonen I, Törrönen E-N, Lok J, Schwab U, El-Nezami H.
The impact of intermittent fasting on gut microbiota: a systematic review of human studies.Front Nutr. 2024;11:1342787.
Read ReviewEcheverria V, Echeverria F, Barreto GE, Echeverría J, Mendoza C.
Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause.Front Pharmacol. 2021;12:644103.
Read ReviewSánchez-Martínez, L., González-Barrio, R., García-Alonso, J., Mena, P., & Periago, J. (2024).
Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk in Postmenopausal Women: A Dietary Trial.Antioxidants, 13(8), 973.
Read ReviewKahleova H, Holtz DN, Strom N, et al.
Complement Ther Med. 2023;79:103002.A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome.
Read ReviewLiaquat M, Minihane AM, Vauzour D, Pontifex MG.
The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?Post Reprod Health. 2025;31(2):105-114.
Read ReviewPark MG, Cho S, Oh MM.
Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome.Diagnostics. 2023;13(6):1193.
Read ReviewPkhaladze L, Davidova N, Khomasuridze A, Shengelia R, Panossian AG.
Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel). 2020;13(5):102
Read ReviewLeach MJ, Moore V.
Black cohosh (Cimicifuga spp.) for menopausal symptoms.Cochrane Database Syst Rev. 2012;9:CD007244.
Read ReviewGerbarg PL, Brown RP.
Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator.Phytomedicine. 2016;000:1-7.
Read ReviewPączek P, Herbst-Kralovetz MM.
Connecting microbiome and menopause for healthy ageing.Nat Microbiol. 2022 Mar;7(3):354-358.
Read ReviewPeters BA, Santoro N, Kaplan RC, Qi Q.
Spotlight on the gut microbiome in menopause: current insights.Int J Womens Health. 2022;14:1059–1072.
Read ReviewPączek P, Herbst-Kralovetz MM.
Connecting microbiome and menopause for healthy ageing.Nat Microbiol. 2022 Mar;7(3):354-358.
Read Review