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References Osteoporosis affects one in three women over 50. Estrogen decline during menopause accelerates bone loss, making weight-bearing exercises, calcium, and vitamin D essential for maintaining bone health. Early intervention can reduce fracture risk, and the gut microbiome may play a role in improving bone density.
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Primary Ovarian Insufficiency (POI)
Researched by:
-
Divine Aleru
ID
Divine Aleru
Read MoreI am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
Primary Ovarian Insufficiency (OI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. OI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, OI can significantly impact a woman’s physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (RT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
-
Divine Aleru
Read More
Researched by:
-
Divine Aleru
ID
Divine Aleru
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Divine Aleru
Overview
Primary Ovarian Insufficiency (POI) is a condition marked by the loss of ovarian function before the age of 40, leading to irregular menstruation, amenorrhea (absence of menstruation), infertility, and other menopausal symptoms.[1] Women with POI experience hypoestrogenism, which results in elevated follicle-stimulating hormone (FSH) levels.[2] While the exact etiology remains unclear, POI can be triggered by genetic factors, autoimmune dysfunction, toxic exposures, and environmental factors. The condition often arises due to ovarian follicle depletion or dysfunction. Genetic studies have highlighted several genes linked to POI, including those affecting ovarian development, DNA repair, and immune function. The microbiome also plays a role, with alterations in the vaginal flora of POI patients showing reduced Lactobacillus abundance, which has been linked to fertility issues.[3] The condition affects approximately 1-2% of women under 40 years of age and 0.1% of those under 30.
Associated Conditions
POI is associated with a range of coexisting conditions that significantly impact the overall health and well-being of affected women. These conditions include autoimmune diseases, chromosomal disorders, and other reproductive health issues. POI leads to infertility as a direct result of ovarian dysfunction and the depletion of the ovarian reserve.[4] In addition to reduced fertility, some women with POI may experience difficulty carrying pregnancies to term.[5][x] The effects of POI extend beyond reproductive health, with women affected by the condition experiencing a higher risk of developing long-term health complications. For example, in the absence of normal ovarian function in decreased estradiol, sex steroid production is reduced, leading to inadequate bone density and the development of osteoporosis or osteopenia.[6] Cardiovascular disease is another serious concern, as estrogen plays a protective role in cardiovascular health, and its loss accelerates the development of atherosclerosis and other heart-related issues. Cognitive decline, including an increased risk of neurodegenerative diseases, has also been observed in women with POI, further compounding the long-term effects of the condition. Recent research also points to the potential role of the microbiome in both the fertility and long-term health of women with POI. Altered vaginal microbiota composition has been observed in women with POI, with reduced Lactobacillus species correlating with lower fertility and increased symptoms of menopause.[7] In addition to these physical health risks, POI also leads to psychological challenges, such as depression, anxiety, and a reduced quality of life due to the emotional and social implications of early menopause.
Causes
Primary Ovarian Insufficiency (POI) is influenced by a variety of genetic, autoimmune, and environmental factors, each contributing to the early loss of ovarian function. Genetic mutations, particularly in X-linked genes like FMR1, are prominent causes of POI.[8][9] Autoimmune responses, such as autoimmune oophoritis, where the body’s immune system attacks ovarian tissue, also play a significant role in the condition. Additionally, environmental factors like exposure to toxic substances and lifestyle choices, including smoking, chemotherapy, and poor diet, further contribute to the early onset of POI.
Causal theories of Primary Ovarian Insufficiency (POI)
| Condition | Description |
|---|---|
| Genetic Mutations | Mutations in genes like FMR1 (associated with Fragile X syndrome) and FOXL2, which is essential for follicle development, significantly increase the risk of POI. FMR1 mutations are the most common genetic cause, with the premutation allele of FMR1 being linked to early ovarian dysfunction and menopause.[10] Women with these mutations may experience accelerated depletion of ovarian follicles and early menopause. FOXL2 mutations impact ovarian function by disrupting folliculogenesis, leading to ovarian insufficiency.[11] |
| Autoimmune Oophoritis | Autoimmune oophoritis is a condition in which the immune system mistakenly targets and destroys ovarian tissue, leading to the depletion of ovarian follicles. This autoimmune response is often triggered by underlying autoimmune diseases such as thyroid disorders (e.g., Hashimoto’s thyroiditis), Addison’s disease, or type 1 diabetes. In women with autoimmune POI, the immune system attacks ovarian follicles, which can result in early ovarian failure and infertility.[12] |
| Environmental Factors | Environmental toxins, such as cigarette smoke, and medical treatments like chemotherapy and radiation therapy are well-documented causes of POI.[13] These treatments can damage the ovaries, leading to accelerated follicular depletion and premature menopause. Children who receive chemotherapy or radiation for cancer are at increased risk, with about 8% of treated children developing POI by the age of 18. The risk is higher (30%) when alkylating agents are used in combination with radiation.[14] |
| Oxidative Stress | Oxidative stress, caused by an imbalance between free radicals and antioxidants, is a major factor contributing to ovarian aging and the depletion of ovarian follicles. This stress can damage ovarian tissue, leading to early ovarian insufficiency.[15] Lifestyle factors, such as poor diet, smoking, and high body mass index (BMI), increase oxidative stress, which accelerates the depletion of ovarian reserve. Additionally, mitochondrial dysfunction is closely linked to oxidative stress and contributes to the pathogenesis of POI.[16][17] |
| Vaginal Dysbiosis | Vaginal dysbiosis, or an imbalance in the vaginal microbiota, has been associated with POI. Studies have shown that women with POI exhibit a reduced abundance of Lactobacillus species, which are critical for maintaining vaginal health and fertility.[18] A disrupted vaginal microbiome may contribute to inflammation and other complications, such as infertility, by altering the local immune environment and interfering with reproductive tract health. The microbial imbalance could play a role in the pathogenesis of POI and its associated fertility issues.[19][x][20] |
Diagnosis
Diagnosing POI involves a combination of clinical symptoms and biochemical testing. Women typically present with symptoms of irregular menstruation, often following a period of oligomenorrhea (infrequent periods) or polymenorrhea (frequent periods).[21] The diagnosis is confirmed through laboratory tests that measure serum FSH and estradiol levels. FSH levels are elevated in women with POI, reflecting the body’s attempt to stimulate the ovaries in response to low estrogen production. Estradiol levels, on the other hand, are low due to ovarian dysfunction.[22] For women with suspected POI, repeated measurements of FSH (usually taken at least a month apart) are essential for confirmation of the diagnosis. In some cases, additional tests such as anti-Müllerian hormone (AMH) levels or ultrasound of the ovaries may be used to assess ovarian reserve.[23] In recent years, research has explored the use of microbiome signatures, metabolomic profiles, and metallomic markers as non-invasive diagnostic tools for POI.[24] Alterations in the vaginal microbiota have been observed in women with POI, suggesting that microbial imbalances may be linked to reproductive health and ovarian function. While these studies are still in their early stages, they hold promise for developing novel diagnostic approaches that go beyond traditional hormonal testing.
Primer
POI is linked to various long-term complications, such as infertility, cardiovascular disease, osteoporosis, and cognitive decline, all resulting from the loss of estrogen production and ovarian reserve.[25] Its etiology involves genetic mutations, particularly in X-linked genes such as FMR1 and FOXL2, which contribute to follicular dysfunction and premature ovarian failure. Environmental factors, including exposure to toxins like pesticides, heavy metals, and iatrogenic causes like chemotherapy, further exacerbate ovarian depletion by inducing oxidative stress, which damages ovarian cells and accelerates follicular atresia. The altered metabolomic signature of POI includes disturbances in lipid and glucose metabolism, contributing to metabolic syndrome, insulin resistance, and an increased risk of cardiovascular disease and osteoporosis. The microbiome, particularly a reduction in beneficial Lactobacillus species, plays a role in inflammatory processes that may worsen reproductive health. Autoimmune oophoritis, where the immune system attacks ovarian tissue, is another significant cause of POI, particularly in women with underlying autoimmune disorders like thyroid disease. These complex interactions between genetic, metabolic, environmental, and immune factors make POI a challenging condition, requiring a multifaceted approach to diagnosis and treatment
Metallomic Signature
Metals, including copper, arsenic, cadmium, mercury, and lead are environmental pollutants that disrupt ovarian function through oxidative stress, inflammation, and cellular damage.[26] The toxic effects of these metals on the ovaries are well-documented, and their role in the pathophysiology of POI has been increasingly recognized.
What is the Metallomic Signature of Primary Ovarian Insufficiency (POI)?
Copper (Cu)
Copper is an essential trace element in the body, but excessive copper levels have been linked to various health problems, including reproductive issues. In the case of POI, copper toxicity is primarily associated with oxidative stress. Elevated copper levels contribute to the production of reactive oxygen species (ROS), which damage ovarian cells and accelerate follicular depletion.[27] Excess copper can alter the balance of metal ions in the ovary, disrupting key metabolic processes necessary for follicle maturation and estrogen production. The accumulation of copper in the ovaries leads to oxidative damage to DNA, proteins, and lipids, contributing to follicular atresia and a decline in ovarian reserve. Moreover, copper toxicity may interact with other toxic metals, exacerbating its detrimental effects on ovarian health.
Arsenic (As)
Arsenic, a toxic metalloid, is widely recognized for its carcinogenic properties, but it also plays a significant role in disrupting ovarian function. Chronic arsenic exposure has been shown to increase oxidative stress, leading to cellular apoptosis in ovarian tissue. Arsenic can bind to sulfhydryl groups in enzymes, altering their function and impairing cellular processes necessary for folliculogenesis. The disruption of ovarian steroidogenesis due to arsenic exposure reduces estradiol production, which in turn exacerbates the symptoms of POI.[28] Studies have demonstrated that elevated arsenic levels in the blood are associated with reduced ovarian reserve and premature ovarian failure. Additionally, arsenic has been linked to autoimmune responses, further compounding its impact on ovarian health.
Cadmium (Cd)
Cadmium is a heavy metal with no known biological function and is highly toxic to human health, particularly affecting the reproductive system. In women with POI, cadmium exposure has been shown to cause significant ovarian damage by triggering oxidative stress, DNA damage, and apoptosis of ovarian cells. Cadmium interferes with the hypothalamic-pituitary-ovarian (HPO) axis, disrupting the production of gonadotropins and sex hormones, which are essential for normal ovarian function.[29] Cadmium has been shown to accumulate in ovarian tissue, where it impairs follicle maturation and estrogen production, leading to follicular depletion.[30] This metal’s ability to induce DNA damage and alter gene expression in ovarian cells increases the risk of premature ovarian failure and infertility.
Mercury (Hg)
Mercury is a highly toxic heavy metal that accumulates in the body through environmental exposure, primarily through the consumption of contaminated seafood. In the context of POI, mercury exposure has been linked to reproductive toxicity, including ovarian dysfunction. Mercury induces oxidative stress in ovarian cells, leading to cellular damage, apoptosis, and a reduction in ovarian reserve.[31] The toxicity of mercury in the ovaries is partly due to its ability to interact with enzymes involved in steroidogenesis, impairing estrogen production and disrupting the menstrual cycle.[32] In addition to its direct effects on ovarian function, mercury exposure has been shown to interfere with the immune system, contributing to autoimmune responses that can further compromise ovarian health.
Lead (Pb)
Lead disrupts antioxidant mechanisms in the body, leading to oxidative stress in ovarian cells. Although it does not directly generate ROS, lead exposure impairs key antioxidant enzymes like SOD and GSH-Px, contributing to cellular damage in the ovaries.[33] This results in decreased ovarian reserve, follicular atresia, and mitochondrial dysfunction, all of which accelerate the onset of POI.[34]
Metabolomic Signature
Studies using advanced techniques such as ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC–MS/MS) have revealed that women with POI exhibit significant changes in serum metabolites, including elevated levels of certain fatty acids, amino acids, and phospholipids.[35] For instance, metabolites involved in arachidonic acid metabolism, which is associated with inflammation and oxidative stress, are significantly altered in POI patients. These changes are thought to reflect the underlying oxidative stress and inflammation that contribute to ovarian dysfunction in POI. Metabolomic profiling has highlighted the disruption of amino acid metabolism, with elevated levels of metabolites such as homocitrulline and indolepropionate observed in POI patients.[36] These metabolites may serve as biomarkers for the condition and offer potential diagnostic and therapeutic insights. The disturbance in glucose metabolism, including insulin resistance and elevated fasting glucose levels, has been identified as a key feature of POI’s metabolic signature, linking it to the increased risk of metabolic syndrome.[37]
Microbiome Signature: Primary Ovarian Insufficiency (POI)
Interventions
Microbiome-targeted interventions (MBTIs) are emerging as promising approaches to manage primary ovarian insufficiency. Recent studies have highlighted the role of microbiome dysbiosis, imbalances in microbial communities, in the pathogenesis of POI. Interventions aimed at restoring microbial balance in the gut and vaginal microbiota are being explored to improve ovarian function and overall reproductive health.
| Class | Mechanisms of Action | MBTI Status |
|---|
| Probiotics | These probiotics modulate the gut and vaginal microbiota, enhancing the abundance of beneficial bacteria, reducing the presence of pathogenic microorganisms, and producing short-chain fatty acids (SCFAs) that support ovarian function.[38] Studies have shown that probiotic supplementation can improve ovarian function and delay ovarian aging by modulating gut microbiota composition and activity.[39] | Experimental |
| Fecal Microbiota Transplantation (FMT) | FMT aims to restore a healthy microbiota composition by introducing diverse microbial communities into the recipient’s gut.[40] This intervention has shown promise in improving ovarian function and delaying ovarian aging in animal models by modulating the gut microbiota.[41] | Under Investigation |
| Dietary Fiber & Prebiotics | Dietary fibers serve as substrates for beneficial gut bacteria, promoting the production of SCFAs like butyrate, which have been shown to regulate estrogen and progesterone production, thereby supporting ovarian function.[42] | Promising Candidate |
| Hormone Replacement Therapy (HRT) | While primarily aimed at hormone regulation, HRT has been observed to influence gut microbiota composition, potentially alleviating dysbiosis associated with POI.[43] HRT reverses Gut microbiome and serum metabolome alterations in POI.[44] | First-line Treatment |
| Metformin (MET) | MET activates the AMPK pathway, improving mitochondrial function, reducing oxidative stress, and modulating inflammation. These effects protect ovarian granulosa cells from chemotherapy-induced damage, thus preserving ovarian function.[45] | Promising |
| Stem Cell Therapy | hUC-MSC exosomes mediate their therapeutic effects by regulating ovarian immune functions and reducing oxidative stress and inflammation, leading to improved ovarian function and fertility.[46] | Promising Candidate |
FAQs
What is the mechanism by which Hormone Replacement Therapy (HRT) improves ovarian function and affects the microbiome in POI patients?
What is the mechanism by which Hormone Replacement Therapy (HRT) improves ovarian function and affects the microbiome in POI patients?
Hormone Replacement Therapy (HRT) is the primary clinical treatment for POI, aimed at restoring the hormonal levels—particularly estrogen—that are essential for maintaining ovarian function. Estrogen directly affects the function of the ovaries and regulates the menstrual cycle, and its replacement alleviates menopausal symptoms such as hot flashes, mood swings, and vaginal dryness. HRT’s impact on the microbiome comes through its regulation of estrogen-sensitive pathways. Research shows that restoring estrogen through HRT can influence gut microbiota composition, reducing dysbiosis and promoting microbial diversity. Estrogen enhances the growth of beneficial microbes and inhibits the proliferation of pathogenic bacteria, improving both immune function and metabolic processes. Additionally, HRT helps to modulate inflammatory pathways, reducing the chronic low-grade inflammation seen in POI. These effects on the microbiome and immune system may explain why HRT improves both ovarian health and overall well-being in POI patients.
How does Metformin work to protect ovarian function in chemotherapy-induced POI, and could it be applied to idiopathic POI cases?
How does Metformin work to protect ovarian function in chemotherapy-induced POI, and could it be applied to idiopathic POI cases?
Metformin, a well-known drug used to manage type 2 diabetes, has demonstrated protective effects against chemotherapy-induced POI. The mechanism involves the activation of the AMPK pathway, which regulates cellular energy balance and reduces oxidative stress. By activating AMPK, metformin enhances mitochondrial function and promotes the survival of ovarian granulosa cells under oxidative stress, which is commonly induced by chemotherapy drugs such as cyclophosphamide and busulfan. In addition to its effects on oxidative stress, metformin also modulates inflammation by activating the PPAR-γ and SIRT1 pathways, which are involved in cellular repair and immune modulation. This makes metformin a promising candidate for treating chemotherapy-induced ovarian damage. While its application in idiopathic POI remains under investigation, its ability to improve ovarian health by regulating metabolic and inflammatory pathways could offer potential benefits for other forms of POI, particularly those linked to metabolic dysfunction.
How do Fecal Microbiota Transplantation (FMT) and Probiotics impact ovarian function in POI, and what are the underlying mechanisms?
How do Fecal Microbiota Transplantation (FMT) and Probiotics impact ovarian function in POI, and what are the underlying mechanisms?
Fecal Microbiota Transplantation (FMT) and probiotics represent innovative microbiome-targeted therapies that aim to restore microbial balance in POI. FMT involves transferring healthy gut microbiota from a donor to a patient to re-establish microbial diversity, which has been shown to improve gut health and modulate systemic inflammation. In POI, FMT could potentially reverse gut dysbiosis, restore hormonal balance, and reduce inflammation that negatively impacts ovarian function. Probiotics, on the other hand, are live microorganisms that, when administered in adequate amounts, can confer health benefits to the host. They help in restoring a healthy gut microbiota by promoting beneficial bacteria like Lactobacillus and Bifidobacterium, which are crucial for metabolic health and immune function. Probiotics influence estrogen metabolism, enhance the production of anti-inflammatory cytokines, and regulate microbial products (e.g., SCFAs) that support ovarian function. The underlying mechanisms include the regulation of immune responses, reduction in oxidative stress, and modulation of metabolic pathways that affect follicular development. Studies have shown that both FMT and probiotics can alter the gut-vagina axis, which is essential for maintaining optimal ovarian health, thus offering promising therapeutic options for POI patients.
Research Feed
Primary ovarian insufficiency
February 5, 2009
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Premature ovarian insufficiency: the context of long-term effects
February 18, 2016
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Primary ovarian insufficiency: Update on clinical and genetic findings
September 24, 2024
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Premature Ovarian Insufficiency: Past, Present, and Future
May 10, 2021
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Premature ovarian insufficiency: an update on recent advances in understanding and management
November 29, 2017
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum
October 3, 2016
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Impact of oxidative stress induced by heavy metals on ovarian function
June 28, 2024
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Metals •
Metals
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin ut laoreet tortor. Donec euismod fermentum pharetra. Nullam at tristique enim. In sit amet molestie
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
August 11, 2023
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Association of dietary preferences with primary ovarian insufficiency (POI)
December 21, 2024
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Recent advances in the nutritional therapy for premature ovarian insufficiency
November 17, 2022
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Changes in the vaginal microbiota associated with primary ovarian failure
July 29, 2020
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Microbiome Insiders can read two study summaries for any topic on Microbiome.
Characteristics of the vaginal microbiome in women with premature ovarian insufficiency
December 8, 2021
/
Microbes •
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study
October 7, 2024
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Microbes •
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Association between premature ovarian insufficiency and gut microbiota
June 5, 2021
/
Microbes •
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment
January 9, 2024
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Female Fertility and Environmental Pollution
November 26, 2020
/
Female Infertility •
Female Infertility
Did you know?
Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).
Polycystic ovary syndrome (PCOS) •
Polycystic ovary syndrome (PCOS)
Did you know?
Women with PCOS produce more than double the amount of anti-Müllerian hormone (AMH) compared to women without PCOS—so much so that some researchers have proposed renaming the condition “AMH syndrome.”
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Evaluation of serum heavy metal levels on primary ovarian insufficiency
July 19, 2017
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Metals •
Metals
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin ut laoreet tortor. Donec euismod fermentum pharetra. Nullam at tristique enim. In sit amet molestie
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Plasma metabolomic characterization of premature ovarian insufficiency
January 5, 2023
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
September 30, 2022
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Metabolic Profile of Patients with Premature Ovarian Insufficiency
October 21, 2018
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses
October 31, 2022
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: A Mendelian randomization study
April 26, 2024
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency
November 28, 2024
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Microbiota and Human Reproduction: The Case of Female Infertility
May 3, 2020
/
Infertility •
Infertility
Did you know?
Despite common perceptions, male factors alone are responsible for about 30% of all infertility cases and contribute to another 20% when combined with female factors. This highlights the importance of evaluating both partners in infertility assessments.
Female Infertility •
Female Infertility
Did you know?
Around 1 in 6 couples experience infertility, with the female factor contributing to about 35% of cases globally, according to a large multinational study by the World Health Organization (WHO).
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Properties of Infertility Microbiome in a Review Article
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause
December 7, 2016
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway
January 16, 2024
/
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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The influence of the gut microbiome on ovarian aging
January 3, 2024
/
Microbes •
Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Gut microbiota: Emerging biomarkers and potential therapeutics for premature ovarian failure
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Butyrate as a Potential Modulator in Gynecological Disease Progression
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Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency
December 23, 2021
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Primary Ovarian Insufficiency (POI) •
Primary Ovarian Insufficiency (POI)
Did you know?
Osteoporosis is a common long-term effect of POI due to low estrogen levels. Estrogen is essential for maintaining bone health. Women with POI, who experience early hormonal declines, are at increased risk for osteoporosis and bone fractures, making bone health a significant concern. Medications like bisphosphonates may help strengthen bones.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
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Female Infertility
Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Metabolomic Signature
Metabolomic signatures are unique metabolite patterns linked to specific biological conditions, identified through metabolomics. They reveal underlying biochemical activities, aiding in disease diagnosis, biomarker development, and personalized medicine. The microbiome significantly affects these signatures, influencing health and disease outcomes through metabolic interactions.
Microbiome-Targeted Interventions (MBTIs)
Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.
Probiotics
Probiotics are live microorganisms that offer significant health benefits when administered in adequate amounts. They primarily work by modulating the gut microbiome, supporting a balanced microbial ecosystem. Probiotics have been shown to improve gut health, modulate immune responses, and even influence metabolic and mental health disorders. With growing evidence supporting their therapeutic potential, probiotics are increasingly recognized for their role in treating conditions like irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), and even mental health conditions like depression and anxiety through their impact on the gut-brain axis.
Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation (FMT) involves transferring fecal bacteria from a healthy donor to a patient to restore microbiome balance.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Menopause
Menopause impacts many aspects of health, including the gut microbiome, weight management, and hormone balance. Diet, probiotics, intermittent fasting, and HRT offer effective management strategies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Female Infertility
Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.
Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Infertility
Infertility is the inability to conceive after 12 months of regular, unprotected sex. It affects both men and women and can be due to various physical, hormonal, or genetic factors. Treatments include medication, surgery, assisted reproductive technologies, and lifestyle changes.
Female Infertility
Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
Primary Ovarian Insufficiency (POI)
Primary Ovarian Insufficiency (POI) is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. This leads to reduced estrogen production and irregular menstrual cycles, which may eventually result in infertility and early menopause-like symptoms. POI can occur due to various reasons, including genetic factors, autoimmune disorders, chemotherapy, or unknown causes. Though often misunderstood and misdiagnosed, POI can significantly impact a woman's physical and emotional well-being. Early diagnosis and appropriate treatment, including hormone replacement therapy (HRT) and fertility interventions, can help manage symptoms, improve quality of life, and in some cases, restore fertility.
References
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- Premature ovarian insufficiency: the context of long-term effects.. Podfigurna-Stopa, A., Czyzyk, A., Grymowicz, M., Smolarczyk, R., Katulski, K., Czajkowski, K., & Meczekalski, B. (2016).. (Journal of Endocrinological Investigation, 39(9), 983–990.)
- Characteristics of the vaginal microbiome in women with premature ovarian insufficiency. Wu, J., Ning, Y., Tan, L. et al.. (J Ovarian Res 14, 172 (2021).)
- Premature Ovarian Insufficiency: Past, Present, and Future. Chon, S. J., Umair, Z., & Yoon, M. (2021).. (Frontiers in Cell and Developmental Biology, 9, 672890.)
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- Premature ovarian insufficiency: the context of long-term effects.. Podfigurna-Stopa, A., Czyzyk, A., Grymowicz, M., Smolarczyk, R., Katulski, K., Czajkowski, K., & Meczekalski, B. (2016).. (Journal of Endocrinological Investigation, 39(9), 983–990.)
- Changes in the vaginal microbiota associated with primary ovarian failure. Wang, J., Xu, J., Han, Q. et al.. (BMC Microbiol 20, 230 (2020).)
- Primary ovarian insufficiency: Update on clinical and genetic findings. Federici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024).. (Frontiers in Endocrinology, 15, 1464803.)
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- The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency. Shelling, A. N., & Ahmed Nasef, N. (2023).. (Antioxidants, 12(8), 1601.)
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- Changes in the vaginal microbiota associated with primary ovarian failure. Wang, J., Xu, J., Han, Q. et al.. (BMC Microbiol 20, 230 (2020).)
- The Vaginal Microbiome in Health and Disease—What Role Do Common Intimate Hygiene Practices Play?. Holdcroft, A. M., Ireland, D. J., & Payne, M. S. (2023).. (Microorganisms, 11(2), 298.)
- Characteristics of the vaginal microbiome in women with premature ovarian insufficiency. Wu, J., Ning, Y., Tan, L. et al.. (J Ovarian Res 14, 172 (2021).)
- Premature ovarian insufficiency: an update on recent advances in understanding and management. Torrealday, S., Kodaman, P. H., & Pal, L. (2017).. (F1000Research, 6, 2069.)
- Primary ovarian insufficiency: Update on clinical and genetic findings. Federici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024).. (Frontiers in Endocrinology, 15, 1464803.)
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- Changes in the vaginal microbiota associated with primary ovarian failure. Wang, J., Xu, J., Han, Q. et al.. (BMC Microbiol 20, 230 (2020).)
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- Impact of oxidative stress induced by heavy metals on ovarian function. Xiao, C., & Lai, D. (2024).. (Journal of Applied Toxicology, 45(1), 107-116.)
- Impact of oxidative stress induced by heavy metals on ovarian function. Xiao, C., & Lai, D. (2024).. (Journal of Applied Toxicology, 45(1), 107-116.)
- Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment. Cui, J., Wang, Y. Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment.. (J Ovarian Res 17, 8 (2024).)
- Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment. Cui, J., Wang, Y. Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment.. (J Ovarian Res 17, 8 (2024).)
- Impact of oxidative stress induced by heavy metals on ovarian function. Xiao, C., & Lai, D. (2024).. (Journal of Applied Toxicology, 45(1), 107-116.)
- Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.. Massányi, P., Massányi, M., Madeddu, R., Stawarz, R., & Lukáč, N. (2020).. (Toxics, 8(4), 94.)
- Impact of oxidative stress induced by heavy metals on ovarian function. Xiao, C., & Lai, D. (2024).. (Journal of Applied Toxicology, 45(1), 107-116.)
- Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.. Massányi, P., Massányi, M., Madeddu, R., Stawarz, R., & Lukáč, N. (2020).. (Toxics, 8(4), 94.)
- Plasma metabolomic characterization of premature ovarian insufficiency. Zhou, XY., Li, X., Zhang, J. et al.. (J Ovarian Res 16, 2 (2023).)
- Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses. Lu, C., Qin, C., Fu, Z., Wang, L., Yi, Y., Xin, M., Zhen, X., Han, C., & Lu, C. (2022).. (Clinical and Translational Medicine, 12(10), e1006.)
- Metabolic Profile of Patients with Premature Ovarian Insufficiency. Podfigurna, A., Stellmach, A., Szeliga, A., Czyzyk, A., & Meczekalski, B. (2018).. (Journal of Clinical Medicine, 7(10), 374.)
- Butyrate as a Potential Modulator in Gynecological Disease Progression.. Kim, N., & Yang, C. (2024).. (Nutrients, 16(23), 4196.)
- Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging.. Lyu, W., Li, D. F., Li, S. Y., Hu, H., Zhou, J. Y., & Wang, L. (2024).. (Critical Reviews in Food Science and Nutrition, 65(17), 3257–3269.)
- Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging.. Lyu, W., Li, D. F., Li, S. Y., Hu, H., Zhou, J. Y., & Wang, L. (2024).. (Critical Reviews in Food Science and Nutrition, 65(17), 3257–3269.)
- The influence of the gut microbiome on ovarian aging.. Huang, F., Cao, Y., Liang, J., Tang, R., Wu, S., Zhang, P., & Chen, R. (2024).. (Gut Microbes, 16(1), 2295394.)
- Butyrate as a Potential Modulator in Gynecological Disease Progression.. Kim, N., & Yang, C. (2024).. (Nutrients, 16(23), 4196.)
- Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause. Sullivan, S. D., Sarrel, P. M., & Nelson, L. M. (2016).. (Fertility and Sterility, 106(7), 1588-1599.)
- Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency.. Jiang, L., Fei, H., Tong, J., Zhou, J., Zhu, J., Jin, X., Shi, Z., Zhou, Y., Ma, X., Yu, H., Yang, J., & Zhang, S. (2021).. (Frontiers in Endocrinology, 12, 794496.)
- Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway. Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z.. (Sci Rep. 2024 Jan 16;14(1):1447.)
- Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection. Dai, F., Liu, H., He, J. et al.. (Stem Cell Res Ther 15, 49 (2024).)
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Premature ovarian insufficiency: the context of long-term effects.Journal of Endocrinological Investigation, 39(9), 983–990.
Read ReviewWu, J., Ning, Y., Tan, L. et al.
Characteristics of the vaginal microbiome in women with premature ovarian insufficiencyJ Ovarian Res 14, 172 (2021).
Read ReviewChon, S. J., Umair, Z., & Yoon, M. (2021).
Premature Ovarian Insufficiency: Past, Present, and FutureFrontiers in Cell and Developmental Biology, 9, 672890.
Read ReviewHuang, Y., Liu, Z., Geng, Y. et al.
The risk factors, pathogenesis and treatment of premature ovarian insufficiencyJ Ovarian Res 18, 134 (2025).
Podfigurna-Stopa, A., Czyzyk, A., Grymowicz, M., Smolarczyk, R., Katulski, K., Czajkowski, K., & Meczekalski, B. (2016).
Premature ovarian insufficiency: the context of long-term effects.Journal of Endocrinological Investigation, 39(9), 983–990.
Read ReviewWang, J., Xu, J., Han, Q. et al.
Changes in the vaginal microbiota associated with primary ovarian failureBMC Microbiol 20, 230 (2020).
Read ReviewFederici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024).
Primary ovarian insufficiency: Update on clinical and genetic findingsFrontiers in Endocrinology, 15, 1464803.
Read ReviewChon, S. J., Umair, Z., & Yoon, M. (2021).
Premature Ovarian Insufficiency: Past, Present, and FutureFrontiers in Cell and Developmental Biology, 9, 672890.
Read ReviewChon, S. J., Umair, Z., & Yoon, M. (2021).
Premature Ovarian Insufficiency: Past, Present, and FutureFrontiers in Cell and Developmental Biology, 9, 672890.
Read ReviewFederici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024).
Primary ovarian insufficiency: Update on clinical and genetic findingsFrontiers in Endocrinology, 15, 1464803.
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Primary Ovarian Insufficiency[Updated 2023 Mar 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
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Premature ovarian insufficiency: an update on recent advances in understanding and managementF1000Research, 6, 2069.
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Primary Ovarian Insufficiency[Updated 2023 Mar 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
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Association of dietary preferences with primary ovarian insufficiency (POI): a mendelian randomization-based analysisBMC Women’s Health 24, 652 (2024).
Read ReviewTucker EJ, Grover SR, Bachelot A, Touraine P, Sinclair AH.
Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic SpectrumEndocr Rev. 2016 Dec;37(6):609-635. Epub 2016 Oct 3.
Read ReviewWang, J., Xu, J., Han, Q. et al.
Changes in the vaginal microbiota associated with primary ovarian failureBMC Microbiol 20, 230 (2020).
Read ReviewHoldcroft, A. M., Ireland, D. J., & Payne, M. S. (2023).
The Vaginal Microbiome in Health and Disease—What Role Do Common Intimate Hygiene Practices Play?Microorganisms, 11(2), 298.
Wu, J., Ning, Y., Tan, L. et al.
Characteristics of the vaginal microbiome in women with premature ovarian insufficiencyJ Ovarian Res 14, 172 (2021).
Read ReviewTorrealday, S., Kodaman, P. H., & Pal, L. (2017).
Premature ovarian insufficiency: an update on recent advances in understanding and managementF1000Research, 6, 2069.
Read ReviewFederici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024).
Primary ovarian insufficiency: Update on clinical and genetic findingsFrontiers in Endocrinology, 15, 1464803.
Read ReviewBenetti-Pinto, C. L., Soares Júnior, J. M., Maciel, G. A., Nácul, A. P., & Yela, D. A. (2020).
Premature ovarian insufficiency: A hormonal treatment approach: Number 2 - August 2020.RBGO Gynecology & Obstetrics, 42(8), 511.
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Changes in the vaginal microbiota associated with primary ovarian failureBMC Microbiol 20, 230 (2020).
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Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiencyClinical Nutrition ESPEN, 65, 331-338.
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The adverse role of endocrine disrupting chemicals in the reproductive system.Frontiers in Endocrinology, 14, 1324993.
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Impact of oxidative stress induced by heavy metals on ovarian functionJournal of Applied Toxicology, 45(1), 107-116.
Read ReviewXiao, C., & Lai, D. (2024).
Impact of oxidative stress induced by heavy metals on ovarian functionJournal of Applied Toxicology, 45(1), 107-116.
Read ReviewCui, J., Wang, Y. Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment.
Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatmentJ Ovarian Res 17, 8 (2024).
Read ReviewCui, J., Wang, Y. Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment.
Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatmentJ Ovarian Res 17, 8 (2024).
Read ReviewXiao, C., & Lai, D. (2024).
Impact of oxidative stress induced by heavy metals on ovarian functionJournal of Applied Toxicology, 45(1), 107-116.
Read ReviewMassányi, P., Massányi, M., Madeddu, R., Stawarz, R., & Lukáč, N. (2020).
Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.Toxics, 8(4), 94.
Xiao, C., & Lai, D. (2024).
Impact of oxidative stress induced by heavy metals on ovarian functionJournal of Applied Toxicology, 45(1), 107-116.
Read ReviewMassányi, P., Massányi, M., Madeddu, R., Stawarz, R., & Lukáč, N. (2020).
Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.Toxics, 8(4), 94.
Zhou, XY., Li, X., Zhang, J. et al.
Plasma metabolomic characterization of premature ovarian insufficiencyJ Ovarian Res 16, 2 (2023).
Read ReviewLu, C., Qin, C., Fu, Z., Wang, L., Yi, Y., Xin, M., Zhen, X., Han, C., & Lu, C. (2022).
Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analysesClinical and Translational Medicine, 12(10), e1006.
Read ReviewPodfigurna, A., Stellmach, A., Szeliga, A., Czyzyk, A., & Meczekalski, B. (2018).
Metabolic Profile of Patients with Premature Ovarian InsufficiencyJournal of Clinical Medicine, 7(10), 374.
Read ReviewKim, N., & Yang, C. (2024).
Butyrate as a Potential Modulator in Gynecological Disease Progression.Nutrients, 16(23), 4196.
Read ReviewLyu, W., Li, D. F., Li, S. Y., Hu, H., Zhou, J. Y., & Wang, L. (2024).
Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging.Critical Reviews in Food Science and Nutrition, 65(17), 3257–3269.
Read ReviewLyu, W., Li, D. F., Li, S. Y., Hu, H., Zhou, J. Y., & Wang, L. (2024).
Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging.Critical Reviews in Food Science and Nutrition, 65(17), 3257–3269.
Read ReviewHuang, F., Cao, Y., Liang, J., Tang, R., Wu, S., Zhang, P., & Chen, R. (2024).
The influence of the gut microbiome on ovarian aging.Gut Microbes, 16(1), 2295394.
Read ReviewKim, N., & Yang, C. (2024).
Butyrate as a Potential Modulator in Gynecological Disease Progression.Nutrients, 16(23), 4196.
Read ReviewSullivan, S. D., Sarrel, P. M., & Nelson, L. M. (2016).
Hormone replacement therapy in young women with primary ovarian insufficiency and early menopauseFertility and Sterility, 106(7), 1588-1599.
Read ReviewJiang, L., Fei, H., Tong, J., Zhou, J., Zhu, J., Jin, X., Shi, Z., Zhou, Y., Ma, X., Yu, H., Yang, J., & Zhang, S. (2021).
Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency.Frontiers in Endocrinology, 12, 794496.
Read ReviewYang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathwaySci Rep. 2024 Jan 16;14(1):1447.
Read ReviewDai, F., Liu, H., He, J. et al.
Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injectionStem Cell Res Ther 15, 49 (2024).
Read Review