Correlation of fecal metabolomics and gut microbiota in mice with endometriosis
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Microbes
Microbes
Microbes, short for microorganisms, are tiny living organisms that are ubiquitous in the environment, including on and inside the human body. They play a crucial role in human health and disease, functioning within complex ecosystems in various parts of the body, such as the skin, mouth, gut, and respiratory tract. The human microbiome, which is […]
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Karen Pendergrass
What was studied?
The study investigated the interaction between fecal metabolomics and gut microbiota in mice with endometriosis (EMS), aiming to identify metabolic changes and microbiota diversity associated with the disease.
Who was studied?
Female C57BL/6J mice, utilized to construct an EMS model, were the subjects of this research, allowing for the examination of fecal metabolites and gut microbiota composition.
What were the most important findings?
Significant findings included the identification of 156 differential metabolites, decreasing the diversity and abundance of gut microbiota in EMS mice, and involving key metabolic pathways such as bile acid biosynthesis and alpha-linolenic acid (ALA) metabolism. Notably, increased levels of chenodeoxycholic and ursodeoxycholic acids and decreased levels of ALA and 12,13-EOTrE were found in EMS mice feces.
What are the greatest implications of this study?
The study suggests that the identified abnormal fecal metabolites, influenced by gut dysbiosis, may be potential markers for diagnosing EMS. This finding opens new avenues for understanding EMS pathogenesis and developing non-invasive diagnostic tools based on fecal metabolite profiles.