How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study Original paper
Researched by:
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Divine Aleru
ID
Divine Aleru
Read MoreI am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Endometriosis
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
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Female Infertility
Female Infertility
Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.
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Divine Aleru
Read More
Researched by:
-
Divine Aleru
ID
Divine Aleru
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Divine Aleru
What was studied?
The study examined how chronic endometritis (CE) influences pregnancy outcomes in women experiencing infertility related to endometriosis. Specifically, it evaluated whether the coexistence of CE in these women affected their ability to conceive and carry pregnancies successfully. Researchers explored the incidence of pregnancy complications and live birth outcomes following combined laparoscopic and hysteroscopic surgical treatment.
Who was studied?
The study involved 685 women diagnosed with infertility associated with endometriosis. Among these participants, 318 women were diagnosed with chronic endometritis (CE group), while 367 women did not have CE (non-CE group). A subset consisting of 123 clinically pregnant women from the CE group and 369 from the non-CE group was analyzed in depth. These women underwent combined laparoscopy and hysteroscopy between January 2018 and December 2020. Data was meticulously gathered from medical records and telephone follow-ups over 24 months.
What were the most important findings?
The research revealed that chronic endometritis was highly prevalent (46.42%) in patients with endometriosis-associated infertility. Patients diagnosed with CE had increased rates of pregnancy complications compared to those without CE. Specifically, there was a significantly higher occurrence of placenta previa, gestational hypertension, and cesarean deliveries in the CE group. The cumulative pregnancy rate post-surgery was lower in patients with both EMS and CE compared to those without CE, although this difference was not statistically significant. However, notably, higher Endometriosis Fertility Index (EFI) scores (7-10) correlated strongly with improved pregnancy outcomes in both groups, suggesting that EFI scores remain reliable predictors of fertility success after surgical intervention.
What are the greatest implications of this study?
The study underscores the importance of identifying and treating chronic endometritis in patients suffering from endometriosis-related infertility. Clinicians should be particularly aware that CE significantly increases the risk of adverse pregnancy outcomes, including placenta previa, gestational hypertension, and higher rates of cesarean deliveries. The findings support incorporating routine diagnostic evaluations and proactive management of CE in fertility treatments. They also emphasize the value of combined hysteroscopic and laparoscopic surgical interventions to potentially improve pregnancy outcomes, with careful monitoring and counseling regarding possible complications post-surgery.
Female Infertility
Female infertility is a multifactorial condition affecting 10-15% of women of reproductive age, often caused by underlying conditions like Bacterial Vaginosis (BV), PCOS, Endometriosis, and Pelvic Inflammatory Disease (PID). Microbiome-targeted interventions (MBTIs) offer a promising approach to restoring balance, improving fertility outcomes, and addressing root causes.
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.