In vitro antibiofilm, antibacterial, antioxidant, and antitumor activities of the brown alga Padina pavonica biomass extract
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Microbes
Microbes
Microbes, short for microorganisms, are tiny living organisms that are ubiquitous in the environment, including on and inside the human body. They play a crucial role in human health and disease, functioning within complex ecosystems in various parts of the body, such as the skin, mouth, gut, and respiratory tract. The human microbiome, which is […]
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Karen Pendergrass
What was studied?
The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica L.
Who was studied?
The subjects of the study were various microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Streptococcus agalactiae. Additionally, the extract’s effect on lung carcinoma cells was tested.
What were the most important findings?
The extract showed high inhibitory action against biofilm formation (88-99% effectiveness). It displayed strong antibacterial activity against several identified bacterial species and moderate activity against others. The extract demonstrated significant antioxidant properties with 84.59% DPPH radical scavenging activity. And the extract exhibited potent anticancer activity against lung carcinoma with a high range of inhibitory percent (1.79-98.25%) and a low IC50 value (15.14 µg/ml).
What are the greatest implications of this study?
This study highlights the potential of Padina pavonica as a source of natural compounds with multiple therapeutic applications, including treating infections, combating cancer, and preventing oxidative stress. The broad spectrum of activities suggests that P. pavonica could be developed into various pharmacological or nutraceutical products, thereby supporting biodiversity conservation and offering new avenues for drug development from marine resources.