Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Microbes
Microbes
Microbes, short for microorganisms, are tiny living organisms that are ubiquitous in the environment, including on and inside the human body. They play a crucial role in human health and disease, functioning within complex ecosystems in various parts of the body, such as the skin, mouth, gut, and respiratory tract. The human microbiome, which is […]
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Karen Pendergrass
What was studied?
The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like Atopobium might be associated with the disease.
Who was studied?
68 participants, from whom 134 samples were collected from the cervical canal, posterior fornix, and uterine cavity for 16s-rRNA sequencing, were included in the study.
What were the most important findings?
Key findings included no significant differences in alpha diversity between the cervical canal and posterior fornix. However, the microbiota profile of patients with adenomyosis and endometriosis differed markedly from the control group, with Atopobium showing significant prevalence in these patients. While no specific biomarkers were identified, PICRUSt analysis revealed several characteristic microbiota functions.
What are the greatest implications of this study?
The study suggests a potentially significant role of microbiota, particularly Atopobium, in the pathogenesis of endometriosis combined with adenomyosis. This finding could lead to new insights into the microbiota-immune-endometriosis system interaction, offering new avenues for understanding and possibly treating endometriosis and adenomyosis. Further research is needed to verify the functions of the microbiota identified and their direct association with the diseases.