Research Progress on the Interaction between Intestinal Flora and MicroRNA in Pelvic Inflammatory Diseases Original paper
Researched by:
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Divine Aleru
ID
Divine Aleru
I am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.
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Divine Aleru
Researched by:
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Divine Aleru
ID
Divine Aleru
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Divine Aleru
What was reviewed?
This review article examined the current scientific progress on the interactions between the intestinal flora (gut microbiota) and microRNAs (miRNAs) in the pathogenesis and treatment of pelvic inflammatory disease (PID). It explores the reciprocal regulatory roles of gut microbiota and miRNAs, highlighting their contributions to immune-inflammatory processes, microbial balance, and disease progression in PID. The review also discusses emerging microbiome-targeted and miRNA-based therapeutic strategies.
Who was reviewed?
The authors synthesized evidence from a broad range of experimental, clinical, and animal studies focusing on women with PID and relevant model systems. These studies investigated changes in gut and reproductive tract microbiota, miRNA expression profiles linked to PID and related complications (e.g., endometritis, ectopic pregnancy), and how modulation of these factors affects inflammation and immune responses. The review also included findings on probiotics, prebiotics, fecal microbiota transplantation, and miRNA-based diagnostics and therapeutics.
What were the most important findings?
The review underscores that PID pathogenesis is closely associated with dysbiosis of the gut microbiota, which disrupts immune homeostasis and triggers chronic inflammation through pathways involving pro- and anti-inflammatory cytokines and immune cell dysregulation. miRNAs emerge as critical regulators, modulating inflammation by targeting signaling pathways like NF-κB, TLR4, and NLRP3 inflammasomes. Specific miRNAs are implicated in PID severity and progression by influencing immune cell function and microbial populations. Furthermore, miRNAs can directly alter the gut microbiome composition, while microbial metabolites influence host miRNA expression, establishing a bidirectional regulatory network. Interventions such as probiotics, prebiotics, dietary adjustments, and fecal microbiota transplantation show promise in restoring microbiome balance and modulating miRNA profiles to alleviate inflammation and improve PID outcomes. This integrated view highlights the microbiome-miRNA axis as a novel frontier for diagnostic markers and targeted therapies in PID.
What are the greatest implications of this review?
This review provides a compelling rationale for developing precision medicine approaches targeting both the microbiome and miRNAs to manage PID more effectively. Understanding the dynamic interplay between gut microbiota and miRNAs can facilitate the identification of novel biomarkers for early diagnosis and prognosis of PID. Additionally, microbiome and miRNA modulation could serve as adjunct or alternative therapies to conventional antibiotics, potentially reducing antibiotic resistance and improving long-term reproductive health. The review calls for further research into the mechanisms governing microbiome-miRNA interactions and clinical trials to validate microbiome-targeted and miRNA-based interventions. Ultimately, this could transform PID management by enabling personalized treatments that address the underlying immune-inflammatory dysregulation.
Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease (PID) is a complex interplay between pathogens, immune responses, and microbial communities. As research continues to uncover the microbiome's role in reproductive health, microbiome-targeted interventions (MBTIs) such as probiotics, prebiotics, and transplants are redefining how we prevent and treat PID. This page dives deep into these innovations, offering a glimpse into the future of personalized, biologically informed women’s healthcare.
Microbiome-Targeted Interventions (MBTIs)
Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
Probiotics
Probiotics are live microorganisms that offer significant health benefits when administered in adequate amounts. They primarily work by modulating the gut microbiome, supporting a balanced microbial ecosystem. Probiotics have been shown to improve gut health, modulate immune responses, and even influence metabolic and mental health disorders. With growing evidence supporting their therapeutic potential, probiotics are increasingly recognized for their role in treating conditions like irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), and even mental health conditions like depression and anxiety through their impact on the gut-brain axis.
Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation (FMT) involves transferring fecal bacteria from a healthy donor to a patient to restore microbiome balance.