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Transvaginal Photobiomodulation for the Treatment of Chronic Pelvic Pain: A Pilot Study

March 18, 2025

  • Women’s Health
    Women’s Health

    Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.

Last Updated: 2024-06-23

Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.

Karen Pendergrass

Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.

The study in question focused on the use of transvaginal photobiomodulation (TV-PBM) as a treatment for chronic pelvic pain (CPP) in women. Here are the details based on the key aspects of the study:

 

What was studied?

The research investigated whether transvaginal photobiomodulation could effectively reduce chronic pelvic pain in women. This was a pilot study aiming to explore the potential benefits of a novel therapy approach using light therapy applied transvaginally to manage pain​​.

 

Who was studied?

The study involved women suffering from chronic pelvic pain. These participants had previously experienced ineffective treatments for their condition and were recruited to evaluate the effectiveness of TV-PBM. Thirteen women completed the study, undergoing a series of nine treatments​​.

 

What were the most important findings?

The study found significant and sustained pain relief in participants up to six months after treatment. It reported a notable reduction in pain scores, with 60% of the participants showing improvement shortly after treatment began, and this effect was maintained throughout the six-month follow-up period. The effect sizes were considered large, suggesting the therapy was highly effective for those it helped​​.

 

What are the greatest implications of this study?

The promising results of this pilot study suggest that TV-PBM could be a viable and effective treatment for managing chronic pelvic pain, a condition that often responds poorly to other forms of treatment. This could lead to a new therapeutic option for many women who currently have limited or ineffective choices. However, further research, including larger and controlled studies, is necessary to confirm these findings and fully establish the therapy’s efficacy, safety, and broader applicability​​.

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