STOP Advisory: Reevaluating Zinc Supplementation in Endometriosis

Excessive zinc intake may worsen endometriosis by activating estrogen receptors, disrupting immune function, and altering the microbiome. A large HANES study found that intake above 14 mg/day significantly increases endometriosis risk. With many supplements exceeding this threshold, routine zinc supplementation may contribute to disease progression rather than prevention, prompting a Suggested Termination of Practice (TOP).