Karen Pendergrass, Standards Team

This review explores the microbiota–gut–brain axis, highlighting the role of gut microbiota in barrier integrity and lymphatic transport. It discusses microbial metabolites, vagus nerve signaling, and meningeal lymphatics as critical communication pathways, emphasizing their implications for gastrointestinal and neurological disorders.

What Was This study examined the impact of heavy metal exposure on the prevalence and differentiation of osteoarthritis (A) and rheumatoid arthritis (A) using interpretable machine learning models. Researchers analyzed data from the National Health and Nutrition Examination Survey (HANES) (2003–2020) to assess how various heavy metals contribute to arthritis risk.Who Was The study population […]

This study explored the association between rheumatoid arthritis and heavy metal exposure, identifying a significant deficiency of copper in A patients. No significant correlations were found for zinc, cobalt, lead, or nickel. The findings suggest that copper deficiency may play a role in A, warranting further research on trace metals in autoimmune diseases.

Rheumatoid arthritis (A) is a systemic autoimmune disease marked by chronic joint inflammation, synovitis, and bone erosion, driven by Th17 imbalance, excessive L-17, NF-α, and L-1 production, and macrophage activation. Emerging evidence links microbial dysbiosis and heavy metal exposure to A, [1][2] with gut microbiota influencing autoimmune activation via Toll-like receptor (LR) signaling, inflammasome activation, […]

What was studied?This study investigated the taxonomic and functional gut microbiota profiles of euthyroid individuals with and without thyroid peroxidase antibodies (POAb), a marker for autoimmune thyroid diseases such as Hashimoto’s thyroiditis. The goal was to assess whether gut microbiota composition differs in individuals with POAb before the clinical onset of autoimmune thyroid disease and […]

This study identifies significant gut microbiota alterations in Hashimoto’s thyroiditis, with reduced beneficial microbes and increased pathogens.

This study revealed novel molecular signatures linking gut microbiota and transcriptome in Hashimoto’s thyroiditis, advancing diagnostic and therapeutic approaches.

Gut microbiota analysis in Hashimoto’s thyroiditis patients identified significant dysbiosis, with increased pro-inflammatory taxa and reduced beneficial microbes, correlating with thyroid autoantibodies.

This review explores the toxicity of heavy metals and pesticides in agricultural ecosystems, detailing their ecological and health impacts. It highlights pathways, bioaccumulation, and synergistic interactions, emphasizing the need for improved agricultural practices and bioremediation to mitigate these toxicants’ harmful effects on soil, plants, and human health.

The study reviewed adverse events linked to nickel hypersensitivity in Essure implants, noting rare reactions and the role of the menstrual cycle in modulating hypersensitivity.