Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
2024-12-29 08:48:32
The Positive Influence of Polyphenols Extracted From Pueraria lobata Root on the Gut Microbiota and Its Antioxidant CapabilityPueraria lobata extract enhances antioxidant activity and modulates gut microbiota by increasing Lactobacillaceae and Bacteroidetes while reducing harmful taxa.
2024-12-28 10:22:45
Plants as source of new therapies for endometriosis: a review of preclinical and clinical studiesThis review assesses plant-derived agents for endometriosis therapy, focusing on mechanisms like inflammation, angiogenesis, and apoptosis. Key agents such as resveratrol and curcumin show preclinical promise, while Chinese herbal medicine (HM) demonstrates clinical utility.
2024-12-28 09:34:31
Fruit and vegetable consumption and risk of endometriosisWhat Was This study explored the potential link between the consumption of fruits and vegetables and the risk of laparoscopically confirmed endometriosis. Using data collected from the Nurses’ Health Study I, the researchers analyzed dietary habits over a 22-year period, investigating whether certain food groups and nutrients influenced the likelihood of developing endometriosis.Who Was Participants […]
2024-12-23 10:11:47
Metabolomic Signature of EndometriosisThe chronic inflammatory state of endometriosis affects energy metabolism, particularly altering glutamine and glutamate levels in tissues. These shifts in amino acid, lipid, sugar, and organic acid metabolisms create a distinct profile for endometriosis.
2024-12-16 08:53:45
Hyperbaric Oxygen Therapy (HBOT) as a Promising Candidate in Endometriosis treatmentBOT demonstrates complete remission and holds significant promise as a candidate for microbiome-targeted intervention for endometriosis.
2024-12-16 08:26:05
Remission of Endometriosis by Hyperbaric Oxygen Treatment in RatsThis study demonstrates hyperbaric oxygen therapy (BOT) achieves complete remission of endometriotic lesions in a rat model by reducing hypoxia, inflammation, and NF-α levels. While BOT shows potential as a non-invasive therapy for endometriosis, further studies are needed to validate its impact on microbiome modulation.
2024-12-16 07:35:04
The effect of hyperbaric oxygen therapy in the inflammatory response in a mouse model of endometriosis: An experimental studyThis study highlights hyperbaric oxygen therapy’s (BOT) role in reducing inflammation and FκB expression in a mouse model of endometriosis. The findings suggest BOT as a promising non-invasive treatment for managing endometriosis-associated inflammation, targeting hypoxia-induced molecular pathways and offering potential microbiome benefits through reduced inflammatory burden.
2024-12-13 13:47:42
Validation of a Low-Nickel Diet as an microbiome-targeted intervention for EndometriosisA low-nickel diet is validated as an BTI for endometriosis because it disrupts nickel-dependent pathogens, rebalances the microbiome, and improves symptoms like pelvic pain and dysmenorrhea.
2024-12-13 08:59:16
Plants as source of new therapies for endometriosis: a review of preclinical and clinical studiesThis review highlights the potential of plant-derived therapies for endometriosis. Key findings include anti-inflammatory, anti-proliferative, and anti-angiogenic effects of herbal extracts and bioactive compounds, offering safer long-term alternatives to conventional treatments.
2024-12-12 17:52:54
Validation of Metronidazole as a microbiome-targeted intervention for EndometriosisMetronidazole is a validated microbiome-targeted intervention (BTI) for endometriosis, reducing key dysbiotic taxa and suppressing inflammation and lesion progression.