Karen Pendergrass, Standards Team

This review explores the significant comorbidity between systemic lupus erythematosus (LE) and endometriosis, emphasizing shared pathological pathways.

This review synthesizes key theories on endometriosis pathogenesis, emphasizing immune, hormonal, and epigenetic interactions in its progression.

The study links endometriosis with a fivefold increased risk of BS in adolescents, emphasizing the role of acyclic pelvic pain severity and inflammation as shared mechanisms. Early screening for BS and microbiome-targeted interventions could improve outcomes in this group.

Fusobacterium infection significantly contributes to endometriosis pathogenesis, activating fibroblast inflammation and lesion formation. Antibiotics like metronidazole show promise.

Zinc is an essential trace element vital for cellular functions and microbiome health. It influences immune regulation, pathogen virulence, and disease progression in conditions like BS and breast cancer. Pathogens exploit zinc for survival, while therapeutic zinc chelation can suppress virulence, rebalance the microbiome, and offer potential treatments for inflammatory and degenerative diseases.

Matrix Metalloproteinases (MPs) are zinc-dependent enzymes that regulate extracellular matrix remodeling, with critical roles in health, disease, and interactions with the microbiome.

This study examined gut microbiota alterations in Immunoglobulin A Nephropathy (AN) and Membranous Nephropathy (N), identifying unique and shared microbial changes linked to disease pathology. The findings suggest potential biomarkers and therapeutic targets through the gut-kidney axis.

Joseph F. Petrosino’s editorial highlights the microbiome’s pivotal role in precision medicine, emphasizing its potential to advance personalized diagnostics and therapeutic strategies. The integration of microbiome signatures with other ‘omics’ data, such as genomics and metabolomics, offers a comprehensive understanding of disease mechanisms and tailored treatments. Petrosino draws parallels between microbiome signature research and genomics, […]

A microbiome specialist is a healthcare or research professional with expertise in the human microbiome—the diverse community of microorganisms that inhabit various body sites, including the gut, skin, oral cavity, and genitourinary tract. Microbiome specialists study how microbial communities interact with human health and disease and apply this knowledge to develop targeted interventions.These professionals often […]

Estrogen receptors (Rs) are specialized proteins that respond to the hormone estrogen, playing a critical role in regulating biological processes such as reproduction, cellular growth, and differentiation.