Karen Pendergrass, Standards Team

What was studied?This study investigated the presence of metalloestrogens in ectopic endometrial tissue from women with endometriosis. Metalloestrogens, heavy metals that can mimic estrogen and may contribute to estrogen-dependent diseases, were the focus, particularly regarding their potential role in the persistence and pathology of endometriosis. The researchers specifically analyzed levels of cadmium, nickel, and lead […]

This review identifies metalloestrogens as a critical factor in hormone disruption and breast cancer risk.

Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol.

What Was The systematic review and meta-analysis examined the relationship between exposure to metalloestrogens—specifically arsenic (As), antimony (Sb), chromium (Cr), cadmium (Cd), copper (Cu), selenium (Se), and mercury (Hg)—and the risk of developing gestational diabetes mellitus (DM). This review aimed to aggregate findings from observational studies to better understand how these metals, which have estrogenic […]

This study provides strong evidence that nickel-rich foods in a gluten-free diet can trigger or exacerbate BS-like gastrointestinal and extraintestinal symptoms in a subset of celiac disease patients, even when the disease is in serological and histological remission. The findings highlight the importance of nickel sensitivity in the pathogenesis of these relapsing symptoms, suggesting that a low-nickel diet can be a valuable intervention to improve patient outcomes. The use of the nickel oral mucosa patch test (Ni omPT) was also validated as a reliable diagnostic tool for identifying nickel-sensitive patients.

Irritable Bowel Syndrome (BS) is a common gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits. Recent research has focused on the gut microbiota’s role in BS, aiming to identify specific microbial signatures associated with the condition.

What was studied?This study investigated the incidence of hypersensitivity to dental metals—specifically zinc, nickel, gold, and palladium—in patients with Irritable Bowel Syndrome (BS). The study aimed to assess whether hypersensitivity to these metals, which are commonly used in dental prostheses, could be linked to immune activation in BS patients. The focus was on understanding how […]

Clinoptilolite zeolite binds nickel ions, reducing pathogen activity, making it a potential therapy for nickel allergies and nickel-induced microbiome imbalances.

What was reviewed?The review focused on the safety and medical applications of clinoptilolite, a naturally occurring zeolite, for in vivo use. The analysis encompassed the physical and chemical properties of clinoptilolite, its detoxifying capabilities, and its potential therapeutic effects in both human and veterinary medicine. The review also considered various studies on clinoptilolite’s role in […]

Phage therapy uses viruses to target and kill specific bacteria, offering a precise alternative to antibiotics, especially for resistant infections.