Karen Pendergrass, Standards Team

What Was The study reviewed the effectiveness of partially hydrolyzed guar gum (HGG), a water-soluble prebiotic dietary fiber, on cognitive function, sleep efficiency, and overall mental health in elderly individuals. The research specifically focused on assessing the impact of HGG supplementation on cognitive domains such as visual memory and simple attention, sleep quality parameters like […]

MAO is a metabolite formed when gut bacteria convert dietary nutrients like choline and L-carnitine into trimethylamine (MA), which is then oxidized in the liver to MAO. This compound is linked to cardiovascular disease, as it promotes atherosclerosis, thrombosis, and inflammation, highlighting the crucial role of gut microbiota in influencing heart health.

This study shows that kidney function is the key regulator of MAO levels, linked to cardiovascular risk. Reno-protective therapies, like LP-1 receptor agonists, may lower MAO levels, offering new strategies for managing cardiovascular and kidney health.

This review underscores the critical role of gut microbiota and MAO in heart failure pathophysiology and opens up new avenues for therapeutic interventions targeting the gut–MAO–F axis. The findings suggest promising directions for future research and clinical applications aimed at improving F patient care and outcomes.

This review emphasizes the significant alterations in gut microbiota in severe chronic heart failure (HF) patients and suggests that gut microbiota modulation could be a promising avenue for therapeutic intervention. The study provides a foundation for future research aimed at leveraging gut microbiota to improve HF management and patient health.

This review explores the gut-heart axis, highlighting how gut microbiota alterations and metabolites like MAO and CFAs contribute to heart failure (F). It evaluates the gut hypothesis, emphasizing bacterial translocation and inflammation in F, and discusses potential interventions.

This review in Frontiers in Cellular and Infection Microbiology examines the vaginal microbiome’s role in health and disease, particularly bacterial vaginosis (V). It highlights the shift from a Lactobacillus-dominant microbiome in health to a dysbiotic state in V, linked to increased risk of TIs, ID, and preterm birth. It also discusses current diagnostic and treatment limitations, emphasizing advanced molecular techniques and innovative therapies like probiotics and vaginal microbiota transplantation (MT) for better management and improved reproductive health outcomes.

Parkinson’s disease (D) is a neurodegenerative disorder primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway, leading to progressive hypokinetic movements [1], and a range of non-motor symptoms including gastrointestinal (I) dysfunction [2]. Emerging evidence suggests that the gut microbiome may influence D through the gut–brain axis. D is one of the […]

What Was The review focused on the potential therapeutic role of minocycline, a semisynthetic tetracycline-derived antibiotic, in Parkinson’s disease (D). It encompassed both preclinical and clinical studies to evaluate minocycline’s neuroprotective effects and its mechanisms of action in various experimental models of neurodegenerative diseases, including cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis (LS), Huntington’s […]

The study showed dramatic, sustained improvements in SD symptoms in dizygotic female twins through a personalized, multidisciplinary approach targeting modifiable lifestyle and environmental factors, including microbiome-targeted interventions. These included dietary changes, gluten-free and casein-free diets, and supplements like omega-3 fatty acids and probiotics to support gut health and overall wellbeing.