Karen Pendergrass, Standards Team

Microbiome Targeted Interventions (BTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.

This study evaluates nickel chelation therapy using MG against multidrug-resistant Salmonella and Klebsiella. MG impaired virulence by inhibiting Ni-dependent enzymes, reduced bacterial load in organs, and improved survival in animal models, offering a promising metallomic intervention.

The radiotracer [111In]BPA5 accumulated in the mouse uterus, with uptake varying according to the estrous cycle, suggesting an increased abundance of relaxed fibronectin during estrogen-dependent phases.

S2, a gallium complex, inhibits tumor invasion by targeting MP-14, with implications for anti-metastatic cancer therapy.

What was studied? The study explored the impact of photobiomodulation therapy using different types of light on the major salivary glands and its subsequent effects on caries risk factors in individuals with high risk for dental caries. The therapy modalities tested included polarized polychromatic light, continuous ED light, and pulsed ED light, each aiming to modify […]

This review highlights gallium’s role as an iron mimic disrupting bacterial iron metabolism, effective against multidrug-resistant pathogens. Innovations in gallium delivery, including nanomaterials and synergistic therapies with antibiotics, address bioavailability challenges and enhance its antimicrobial potency.

What was studied? The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica Who was studied? The subjects of the study were various microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Streptococcus agalactiae. Additionally, […]

What was studied?The study investigated the antimicrobial, probiotic, and immunobiological effects of the Henola Cannabis sativae extract and its combinations with specific carriers: polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, magnesium aluminometasilicate, and hydroxypropyl-β-cyclodextrin.  The study demonstrated that Henola Cannabis sativae extract, particularly when combined with carriers like hydroxypropyl-β-cyclodextrin, exhibits strong antimicrobial activity against various pathogens […]

What was studied? The study focused on terpenes derived from plants as potential antimicrobial agents, particularly their effectiveness against antibiotic-resistant infections. This included an exploration of the diverse mechanisms by which terpenes combat microbial resistance, their bioavailability, and the synergistic effects when combined with other antimicrobials. Who was studied? The research mainly involved microbial organisms that […]

What was studied?The study investigated the antimicrobial effects of essential oils derived from the Colombian plant Lippia origanoides, specifically focusing on two terpenes, thymol and carvacrol, against polymicrobial biofilms of Streptococcus mutans, Lactobacillus rhamnosus, and Candida albicans. The study also assessed the cytotoxic effects of these compounds on human skin keratinocytes (CaT) and periodontal ligament […]