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Karen Pendergrass, Standards Team

About

Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.

Recent Posts

2024-06-23 08:03:12

Hyperbaric oxygen therapy counteracts Pseudomonas aeruginosa biofilm micro-compartment phenomenon in murine thermal wounds

What was studied? The study examined the role of biofilms in chronic infections and evaluated whether current medical approaches are effectively targeting biofilm-related infections. Who was studied? The study focused on clinical observations and laboratory analyses involving patients with chronic infections. It analyzed biofilm samples and treatment outcomes in these patients. What were the most important findings?The […]

2024-06-23 08:03:12

Natural favonols: actions, mechanisms, and potential therapeutic utility for various diseases

The review investigated the biological and medicinal importance of flavonols, particularly their roles in disease prevention and treatment. The focus was on their antioxidative properties and their potential therapeutic utility against diabetes, cancer, cardiovascular diseases, and microbial infections.The key findings highlighted the protective roles of flavonols such as quercetin, myricetin, kaempferol, and fisetin against oxidative […]

2024-06-23 08:03:11

Urinary lead concentration and composition of the adult gut microbiota in a cross-sectional population-based sample

What was studied?The study examined the association between urinary lead concentrations and changes in the gut microbiota composition in a population-based sample of adults. The research explored how varying levels of lead exposure could impact microbial diversity, richness, and specific bacterial taxa within the gut. Who was studied?The study population comprised adults from Wisconsin, SA, who […]

2024-06-23 08:03:10

Copper in microbial pathogenesis: meddling with the metal

What was studied?The study investigated the role of copper in microbial pathogenesis. Specifically, it examined how copper serves as both a necessary nutrient for microbial organisms and a microbial weapon used by hosts against pathogens. The research explored copper’s dual roles, its involvement in various microbial resistance mechanisms, and its interaction with the host’s immune […]

2024-06-23 08:03:10

Influence of heavy metal exposure on gut microbiota: Recent advances

What was studied? The study investigated the impact of heavy metal exposure on the composition and function of gut microbiota. Specifically, it looked at how heavy metals such as arsenic, cadmium, lead, and mercury affect the diversity, richness, and metabolism of gut bacteria. Who was studied? The research encompassed various model organisms, including humans, mice, rats, […]

2024-06-23 08:03:09

Endometriosis and adenomyosis: shared pathophysiology

 What was studied?The study focused on the pathophysiology, genetic variants, and epigenetic abnormalities underlying endometriosis and adenomyosis. It emphasized the mechanisms through which these conditions develop, the somatic mutations and epigenetic changes in endometrial and adenomyotic tissues, and the clinical implications of these findings. The primary genetic alterations studied include mutations in the RAS gene […]

2024-06-23 08:03:08

Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis.

What was studied?The research focused on examining the effects of CB 126, a dioxin-like pollutant, on gut health and microbiota as well as metabolic homeostasis in a mouse model predisposed to cardiometabolic diseases. The study investigated how exposure to this pollutant influences the gut microbiome, intestinal and systemic inflammation, metabolic hormones, and the development of […]

2024-06-23 08:03:08

Dioxin-like PCBs and Endometriosis

What was studied?The study focused on the potential impact of environmental exposure to dioxin-like polychlorinated biphenyls (CBs) on the development of endometriosis. It specifically reviewed the complexities and challenges of determining the effects of such toxicants on human health, with an emphasis on reproductive tract diseases. Who was studied?The research predominantly referenced studies involving both human […]