Karen Pendergrass, Standards Team

What was reviewed?The study reviewed the relationship between the gut microbiota and endometriosis, focusing on how the gut microbiota may influence the pathogenesis, diagnosis, and potential treatment of endometriosis through various mechanisms such as estrogen modulation, immune response, and inflammation. Who was reviewed?The review did not involve specific individuals as subjects of study but instead synthesized […]

What was studied?The study explored the therapeutic mechanisms and future perspectives of Vaginal Microbiota Transplantation (MT). It focused on transferring healthy vaginal microbiota from a donor to recipients with dysbiotic vaginal microbiomes to restore normal microbial composition and function. Who was studied?The study didn’t involve direct experimentation on individuals. Instead, it reviewed existing research and clinical […]

What was studied?The study focused on the relationship between oral-gut dysbiosis and chronic systemic inflammation, particularly in the context of periodontitis and its associated diseases. It reviewed the mechanisms underlying the crosstalk between the microbiome and the host, and explored novel precision medicine approaches aimed at controlling systemic inflammation by modulating the microbiome. The study […]

What was reviewed?The review evaluated the evidence for clinical effects of various microbiome-targeted interventions (BTIs) on cardiometabolic traits. The interventions assessed included dietary changes, dietary supplementation, prebiotics, probiotics, synbiotics, and other therapeutic strategies targeting the gut microbiome. The review aimed to understand how these interventions influence cardiometabolic health outcomes and to identify the mechanisms through […]

What was studied?The study investigated whether the induction of endometriosis in mice affects the composition of their gut microbiota. It tested this by transplanting uterine tissue fragments into mice and analyzing changes in the gut microbiota before and after endometriosis induction. Who was studied?Female BL/6 wild-type mice and FP+ transgenic donor mice were used. Uterine tissue […]

This review explores microbiota-targeted interventions for mental health, including probiotics, prebiotics, synbiotics, MT, and diet. While promising, large-scale trials are needed to refine evidence-based strategies. Microbiota-based therapies may serve as adjuncts for psychiatric care, highlighting the gut-brain axis as a key target for future research.

What was studied?The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like Atopobium might be associated with the disease. Who was studied?68 participants, from whom 134 samples were collected from the cervical canal, posterior fornix, and uterine cavity for 16s-rRNA sequencing, were included in […]

What was studied?The study examined the gut microbiota in women with endometriosis compared to healthy controls. It aimed to explore differences based on disease localization, symptoms, or treatment and assess the gut microbiota’s potential role in the pathogenesis of endometriosis. Who was studied?66 women diagnosed with endometriosis at Skåne University Hospital were studied alongside 198 matched […]

What was studied?The study investigated the interaction between fecal metabolomics and gut microbiota in mice with endometriosis (MS), aiming to identify metabolic changes and microbiota diversity associated with the disease. Who was studied?Female BL/6J mice, utilized to construct an MS model, were the subjects of this research, allowing for the examination of fecal metabolites and gut […]

This study examines the role of the vaginal microbiome in distinguishing chronic pelvic pain caused by endometriosis and adenomyosis. Findings highlight specific microbial signatures associated with pain severity, offering potential non-invasive biomarkers for differential diagnosis and targeted therapeutic strategies.