Karen Pendergrass, Standards Team

This study identifies microbiota alterations in ovarian endometrioma, showing distinct microbial shifts in peritoneal fluid extracellular vesicles. Enrichment of Pseudomonas and Acinetobacter, alongside depletion of Propionibacterium and Actinomyces, suggests inflammatory contributions to pathogenesis. Findings highlight the diagnostic potential of microbiota-derived Vs in endometrioma management.

What was studied?The study investigated the microbiota distribution across the entire female reproductive tract of endometriosis (MS) patients and non-MS women, aiming to identify MS-specific bacterial species and examine the relationship between flora and disease development. Who was studied?Fifty women undergoing laparoscopic surgery for benign gynecological diseases or pelvic endometriosis at Peking University Shenzhen Hospital were […]

What was studied?The study focused on characterizing the gut and vaginal microbiome profiles of women with endometriosis compared to controls without the disease, exploring the potential of these profiles as less-invasive diagnostic tools for assessing the severity of endometriosis. Who was studied?Fifty-nine women participated in the study, including 35 with endometriosis and 24 control subjects. Rectal […]

Who was studied?The study included forty-nine symptomatic women diagnosed with endometriosis via laparoscopy, who volunteered to participate in the randomized trial. These women were undergoing treatment with long-acting RH agonists and were subsequently monitored for up to six years. What were the most important findings?The study’s key findings indicate that long-term use of RH agonists results […]

What was studied?The study investigated the role of gut microbiota in endometriosis (M), focusing on its differences between individuals with stage 3/4 M and healthy controls and how these differences correlate with serum hormone levels and inflammatory cytokines. Who was studied?The research involved 12 patients diagnosed with stage 3/4 endometriosis and 12 healthy control subjects. The […]

What was studied?The research investigated the impact of antibiotic treatment on the progression of endometriosis, specifically examining how altering the gut microbiota with antibiotics affects the development of endometriotic lesions in a mouse model. Who was studied?Mice subjected to surgically induced endometriosis were studied. These mice were treated with either broad-spectrum antibiotics or metronidazole to assess […]

What was studied?The research focused on investigating the impact of murine endometriosis on gut microbiota composition using high-throughput NA sequencing to explore how the disease affects intestinal microbial communities. Who was studied?The study subjects were mice. These animals were divided into two groups: one group with induced endometriosis through the intraperitoneal injection of endometrial tissues and […]

What was studied?The research focused on investigating microbial colonization in women’s intrauterine environment and cystic fluid, utilizing a molecular approach to detect bacterial presence. This involved examining variations in bacterial types and their implications in the context of endometriosis and treatment effects.Who was studied?The study included 32 women, evenly divided between those diagnosed with endometriosis […]

What was studied?The study investigated the microbiota in the cervical mucus of women with and without endometriosis using next-generation sequencing (GS) technologies. It aimed to clarify whether cervical mucus in women with endometriosis is contaminated with bacteria, which could potentially transmigrate into the intrauterine cavity, influencing the pathogenesis of endometriosis. The research explored the bacterial […]

What was studied?The study investigated the relationship between inflammatory markers (L-6, L-10, L-13, and NF-α), the composition of bacterial flora in peritoneal fluid, and infertility in patients with endometriosis. Who was studied?The participants included 55 patients diagnosed with endometriosis and infertility (observation group) attending a Gynecology Clinic from June 2014 to July 2017 and 30 individuals […]