Karen Pendergrass, Standards Team

Transvaginal photobiomodulation (VPBM) is an emerging therapeutic modality that uses light therapy to address various gynecological and pelvic health issues. This treatment is noninvasive and uses specific wavelengths of light to stimulate cellular functions, promoting healing and reducing inflammation.

Lipopolysaccharide (PS), a potent endotoxin present in the outer membrane of Gram-negative bacteria that causes chronic immune responses associated with inflammation.

Metabolomic signatures are unique metabolite patterns linked to specific biological conditions, identified through metabolomics. They reveal underlying biochemical activities, aiding in disease diagnosis, biomarker development, and personalized medicine. The microbiome significantly affects these signatures, influencing health and disease outcomes through metabolic interactions.

The estrobolome is a group of gut bacteria that metabolize estrogen, impacting its levels and effects in the body. By modulating estrogen reabsorption and excretion, the estrobolome influences hormonal balance and risks of estrogen-related conditions, making it a target for therapeutic interventions.

The Genetic and Epigenetic Theory of Disease posits that genetic mutations and epigenetic modifications, influenced by environment and lifestyle, impact gene function and disease development, providing insights into disease mechanisms and potential personalized treatments.

The Microbiome Theory posits that gut balance promotes health, while imbalances (dysbiosis) cause disease, suggesting restoration as treatment.

Müllerianosis theory posits that embryonic Müllerian duct remnants misplace and differentiate, forming endometrial-like tissues in non-uterine locations post-puberty, contributing to conditions like endometriosis.

Lymphovascular Metastasis Theory posits that endometrial cells spread via blood and lymph systems, causing distant endometriosis. Evidence is promising but limited.

Coelomic Metaplasia Theory could help explain the cases of endometriosis in men or in women who are not yet menstruating.

The environmental theory of endometriosis suggests exposure to toxins like dioxins and CBs may contribute to its development by disrupting hormones, modulating the immune system, and promoting inflammation.