Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
2021-01-01 00:00:00
Understanding of the Site-Specific Microbial Patterns towards Accurate Identification for Patients with Diarrhea-Predominant Irritable Bowel SyndromeThis study identifies site-specific microbial patterns in BS-D patients, highlighting Bacteroides, Prevotella, and Oscillospira in the rectal mucosa as biomarkers. Findings suggest that rectal mucosa sampling may enhance diagnostic accuracy, paving the way for personalized microbiome-based treatments for BS-D.
2021-01-01 00:00:00
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment2021-01-01 00:00:00
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer2021-01-01 00:00:00
Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment2021-01-01 00:00:00
APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer Disease2021-01-01 00:00:00
Oral Microbiota Changes in Elderly Patients, an Indicator of Alzheimer’s Disease2020-01-01 00:00:00
A cross-sectional pilot study of birth mode and vaginal microbiota in reproductive-age women2020-01-01 00:00:00
Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and LesionThis study reveals a distinct microbiome profile in deep endometriosis, with unique bacterial communities in lesion sites, suggesting a role in inflammation and disease progression. Potentially pathogenic genera like Pseudomonas and Alishewanella were abundant, highlighting their possible involvement in endometriotic lesion maintenance and inflammatory responses.
2020-01-01 00:00:00
Microbiota composition and distribution along the female reproductive tract of women with endometriosisThis study maps the microbiota composition along the reproductive tract in endometriosis patients, revealing microbial dysbiosis, reduced Lactobacillus, and increased Pseudomonas and Sphingobium in upper reproductive sites. These findings suggest potential microbial contributions to inflammation, lesion persistence, and new biomarkers for diagnosing endometriosis.
2020-01-01 00:00:00
Correlation of fecal metabolomics and gut microbiota in mice with endometriosisThis study identifies gut microbiota and metabolomic shifts in endometriosis, with altered bile acid biosynthesis and LA metabolism. Elevated DCA and DCA levels, coupled with microbial changes, suggest potential biomarkers and therapeutic targets for managing inflammation in endometriosis.