Karen Pendergrass, Standards Team

This study identifies the vaginal microbiome as a predictor of endometriosis severity, highlighting microbial shifts that correlate with rASRM staging. Anaerococcus emerged as a key biomarker for advanced disease stages, while ST V dominance during menstruation suggests inflammatory shifts. Findings support the potential of non-invasive microbiome-based diagnosis for endometriosis.

This study reveals a distinct microbiome profile in deep endometriosis, with unique bacterial communities in lesion sites, suggesting a role in inflammation and disease progression. Potentially pathogenic genera like Pseudomonas and Alishewanella were abundant, highlighting their possible involvement in endometriotic lesion maintenance and inflammatory responses.

This study maps the microbiota composition along the reproductive tract in endometriosis patients, revealing microbial dysbiosis, reduced Lactobacillus, and increased Pseudomonas and Sphingobium in upper reproductive sites. These findings suggest potential microbial contributions to inflammation, lesion persistence, and new biomarkers for diagnosing endometriosis.

This study identifies gut microbiota and metabolomic shifts in endometriosis, with altered bile acid biosynthesis and LA metabolism. Elevated DCA and DCA levels, coupled with microbial changes, suggest potential biomarkers and therapeutic targets for managing inflammation in endometriosis.