Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
2020-01-01 00:00:00
Microbiota composition and distribution along the female reproductive tract of women with endometriosisThis study maps the microbiota composition along the reproductive tract in endometriosis patients, revealing microbial dysbiosis, reduced Lactobacillus, and increased Pseudomonas and Sphingobium in upper reproductive sites. These findings suggest potential microbial contributions to inflammation, lesion persistence, and new biomarkers for diagnosing endometriosis.
2020-01-01 00:00:00
Correlation of fecal metabolomics and gut microbiota in mice with endometriosisThis study identifies gut microbiota and metabolomic shifts in endometriosis, with altered bile acid biosynthesis and LA metabolism. Elevated DCA and DCA levels, coupled with microbial changes, suggest potential biomarkers and therapeutic targets for managing inflammation in endometriosis.
2020-01-01 00:00:00
Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot studyThis study identifies microbiome shifts in the lower genital tract of Chinese women with endometriosis, marked by Atopobium enrichment and changes in ribosome biogenesis and immune modulation. Findings suggest potential non-invasive biomarkers and therapeutic targets for endometriosis and adenomyosis.
2020-01-01 00:00:00
Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study2020-01-01 00:00:00
Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease2020-01-01 00:00:00
Classifying dementia progression using microbial profiling of saliva2020-01-01 00:00:00
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer’s Disease2019-01-01 00:00:00
Diversity of vaginal microbiome and metabolome during genital infections2019-01-01 00:00:00
The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy ControlsThis study reveals distinct microbiome shifts in the vaginal, cervical, and gut microbiota of women with stage 3/4 endometriosis. The absence of Atopobium and elevated Gardnerella in reproductive sites suggest immune dysregulation, while Shigella dominance in stool samples correlates with bowel involvement, highlighting potential diagnostic biomarkers.
2019-01-01 00:00:00
Molecular detection of microbial colonization in cervical mucus of women with and without endometriosisThis study identifies intrauterine microbial colonization in endometriosis, with enriched Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. RHa therapy exacerbated microbial imbalances, highlighting potential therapeutic targets for managing inflammation and infection in endometriosis. Findings suggest microbial modulation may enhance treatment outcomes.