Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
2019-01-01 00:00:00
Molecular detection of microbial colonization in cervical mucus of women with and without endometriosisThis study identifies intrauterine microbial colonization in endometriosis, with enriched Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. RHa therapy exacerbated microbial imbalances, highlighting potential therapeutic targets for managing inflammation and infection in endometriosis. Findings suggest microbial modulation may enhance treatment outcomes.
2019-01-01 00:00:00
Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formationThis study found that endometriosis does not induce significant changes in the fecal bacteriota composition during the acute phase of lesion formation. Findings suggest that gut microbial shifts in endometriosis may emerge only during chronic disease stages, highlighting the need for targeted microbiome interventions over prolonged periods.
2019-01-01 00:00:00
Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort2019-01-01 00:00:00
Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway2019-01-01 00:00:00
Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota2019-01-01 00:00:00
Analysis of Salivary Microbiome in Patients with Alzheimer’s Disease2018-01-01 00:00:00
Endometriosis induces gut microbiota alterations in miceThis study demonstrates that endometriosis induces gut microbiota alterations in a murine model, particularly increasing the Bacteroidetes ratio and enriching Bifidobacterium and Parasutterella. These shifts suggest dysbiosis as a contributing factor to inflammation and immune dysregulation, supporting the potential for microbiota-targeted therapies in endometriosis management.
2018-01-01 00:00:00
Inflammatory cytokines IL-6, IL-10, IL-13, TNF-α and peritoneal fluid flora were associated with infertility in patients with endometriosisThis study reveals that inflammatory cytokines (L-6, L-10, L-13, and NF-α) are significantly elevated in the peritoneal fluid of endometriosis patients with infertility. These findings suggest their potential role as diagnostic biomarkers and therapeutic targets for managing reproductive complications in endometriosis.
2018-01-01 00:00:00
The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder2018-01-01 00:00:00
Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease