Karen Pendergrass, Standards Team

This study found no significant correlation between serum calprotectin levels and the severity of endometriosis. Despite its known role as an inflammatory biomarker, calprotectin did not differentiate between stages of disease, suggesting limited utility in clinical staging and reinforcing the need for localized biomarker assessment.

Hypersensitivity to mercury and nickel was significantly more common in fatigued and autoimmune patients than in healthy controls. Removal of dental metals reversed symptoms and immune activation, suggesting that metal-driven immune dysregulation may underlie fatigue and autoimmunity.

A low-nickel diet significantly reduced ERD symptoms in 95% of participants, regardless of patch test status. The results suggest dietary nickel may contribute to ERD pathophysiology independently of classical allergy mechanisms.

Nickel allergic contact mucositis was identified in over 90% of endometriosis patients with BS-like symptoms. A low-nickel diet significantly reduced gastrointestinal, extra-intestinal, and gynecological symptoms, revealing nickel sensitivity as a key driver of endometriosis symptomatology.

What was studied?This pilot study evaluated the prevalence of nickel (Ni) allergy in individuals diagnosed with irritable bowel syndrome (BS) and investigated the clinical efficacy of a low-nickel diet (NiD) in this population. Specifically, the authors assessed the impact of the dietary intervention on gastrointestinal symptoms, intestinal permeability, quality of life, and psychological status in […]

This review highlights the safety and efficacy of phage therapy for chronic and prosthetic joint infections, showing a 91% success rate. Targeted pathogens include P. aeruginosa and S. aureus, key MAs in wound microbiomes, underscoring phages as viable interventions for biofilm-associated, drug-resistant infections.

Tinidazole shows strong alignment with endometriosis microbiome signatures by targeting MAs such as Prevotella and Fusobacterium. Its pharmacological profile and potential for microbial realignment make it a compelling candidate for fast-tracked translational research and microbiome-targeted intervention.

The Research Track (FT) designation is a priority label used within the Microbiome Signatures framework to identify microbiome-targeted interventions that demonstrate exceptional translational potential and clinical relevance. This designation highlights interventions that warrant accelerated research, validation, and collaborative exploration due to their alignment with condition-specific microbiome signatures and their capacity to impact disease pathogenesis or […]

This study demonstrates that peritoneal fluid-to-plasma ferritin and lactoferrin ratios distinguish endometriosis stage and severity. Iron overload and shifting iron-binding protein profiles reveal a localized dysregulation that may influence disease progression and potentially pathogenic microbiome selection.

This chapter reviews hyperaccumulator plants, especially in the Brassicaceae family, and their mechanisms of metal uptake. It highlights implications for human health, including how high-metal diets may shift the microbiome toward dysbiosis—an insight relevant to conditions like endometriosis where metallomic imbalances and microbial disruptions intersect.