Did you know?
The gut microbiome produces over 90% of the body’s serotonin, a key neurotransmitter that regulates mood, sleep, and cognition.
Brain Health
Researched by:
-
Karen Pendergrass
ID
Karen Pendergrass
Read MoreKaren Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
Fact-checked by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read MoreKimberly Eyer, a Registered Nurse with 30 years of nursing experience across diverse settings, including Home Health, ICU, Operating Room Nursing, and Research. Her roles have encompassed Operating Room Nurse, RN First Assistant, and Acting Director of a Same Day Surgery Center. Her specialty areas include Adult Cardiac Surgery, Congenital Cardiac Surgery, Vascular Surgery, and Neurosurgery.
Brain health encompasses the overall functioning and well-being of the brain, including cognitive function, emotional and psychological well-being, neurological integrity, behavioral health, neurodevelopmental health, age-related brain health, and brain resilience and plasticity.
Research feed -
Karen Pendergrass
Read More
Researched by:
-
Karen Pendergrass
ID
Karen Pendergrass
Read More
Fact-checked by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Microbiome Signatures
Overview 
FAQs 
Research Feed Overview
Brain health encompasses the overall functioning and well-being of the brain, including cognitive function, emotional and psychological well-being, neurological integrity, behavioral health, neurodevelopmental health, age-related brain health, and brain resilience and plasticity. The emerging field of neuro-microbiomics explores the complex interactions between the gut microbiome and brain health through the gut-brain axis, highlighting the role of gut microbiota in influencing neurodevelopment, cognitive function, mood regulation, neuroinflammation, and neurodegeneration. This category page serves as a resource for finding information on various brain health conditions such as Parkinson’s disease and Autism Spectrum Disorder (ASD), providing insights into how microbiome signatures are linked to various brain health conditions and offering a gateway to explore these connections and potential microbiome-targeted interventions (MBTIs) in depth.
Gut-Brain Axis
The gut-brain axis is a complex, bidirectional communication network that links the central nervous system (CNS) and the gastrointestinal tract. This connection is facilitated through neural, hormonal, and immune pathways, with the vagus nerve playing a central role in transmitting signals between the gut and the brain. The gut microbiome, consisting of trillions of microorganisms, significantly influences this axis by producing neurotransmitters, modulating immune responses, and affecting the permeability of the gut barrier. Disruptions in the gut microbiome, known as dysbiosis, have been associated with various neurological and psychiatric conditions, such as depression, anxiety, and neurodegenerative diseases. Understanding the gut-brain axis is crucial for exploring how gut health can impact brain function and overall mental well-being.
Conditions
The brain health section of the Microbiome Signatures database is a growing resource aimed at cataloging the distinct microbial patterns linked to various brain-related conditions. Although the collection is still expanding, it currently features microbiome signatures for select brain health conditions. As research in this area progresses, additional signatures will be incorporated, enhancing our knowledge of the microbiome’s influence on brain function and disorders. This ongoing development seeks to create a more robust and useful tool for researchers and clinicians exploring the connections between the gut microbiome and brain health.
FAQs
What is brain health?
What is brain health?
Brain health refers to the holistic functioning of the brain across multiple domains, including cognition, mood, neurological function, and resilience. It is crucial because the brain controls essential functions that impact every aspect of life, from basic survival to complex cognitive tasks, emotional regulation, and behavior.
How does the gut microbiome influence brain health?
How does the gut microbiome influence brain health?
The gut microbiome impacts brain health through the gut-brain axis, a bidirectional communication network between the gastrointestinal tract and the central nervous system. Gut microbiota influence brain function by modulating immune responses, producing neuroactive compounds, and regulating systemic inflammation, all of which can affect cognition, mood, and neurological integrity.
What brain health conditions are associated with the microbiome?
What brain health conditions are associated with the microbiome?
Conditions such as Alzheimer’s disease, Parkinson’s disease, depression, anxiety, autism spectrum disorder (ASD), and multiple sclerosis (MS) have been linked to the gut microbiome. Research suggests that gut dysbiosis may contribute to the onset or progression of these conditions through mechanisms like neuroinflammation and altered neurotransmitter production.
What role does the microbiome play in cognitive function?
What role does the microbiome play in cognitive function?
The microbiome influences cognitive function by affecting the gut-brain axis, including the production of neurotransmitters and the modulation of inflammatory pathways. Disruptions in the microbiome have been associated with cognitive impairments, suggesting that maintaining a healthy microbiome could support cognitive health.
How does age affect the relationship between the microbiome and brain health?
How does age affect the relationship between the microbiome and brain health?
As individuals age, changes in the composition of the gut microbiome can influence brain health, potentially exacerbating age-related conditions like cognitive decline and neurodegenerative diseases. Understanding these changes may offer therapeutic opportunities to promote healthy brain aging through microbiome modulation.
What is the significance of brain resilience and plasticity in relation to the microbiome?
What is the significance of brain resilience and plasticity in relation to the microbiome?
Brain resilience refers to the brain’s ability to recover from injury or stress, while plasticity is its capacity to adapt and reorganize. The microbiome is thought to play a role in enhancing these capabilities, potentially aiding recovery from brain injuries and supporting cognitive and emotional adaptability.
Can microbiome interventions improve brain health?
Can microbiome interventions improve brain health?
There is growing evidence that interventions targeting the microbiome, such as probiotics, prebiotics, and dietary changes, may positively influence brain health. These interventions aim to restore a healthy gut microbiome balance, potentially improving outcomes in conditions like depression, anxiety, and cognitive decline.
Research Feed
The gut microbiome in neurological disorders
November 18, 2019
/
Brain Health
•
Brain Health
Did you know?
The gut microbiome produces over 90% of the body’s serotonin, a key neurotransmitter that regulates mood, sleep, and cognition.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Neuromicrobiology, an Emerging Neurometabolic Facet of the Gut Microbiome?
January 17, 2023
/
Brain Health
•
Brain Health
Did you know?
The gut microbiome produces over 90% of the body’s serotonin, a key neurotransmitter that regulates mood, sleep, and cognition.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Effectiveness of Partially Hydrolyzed Guar Gum on Cognitive Function and Sleep Efficiency in Healthy Elderly Subjects in a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study
April 19, 2024
/
Brain Health
•
Brain Health
Did you know?
The gut microbiome produces over 90% of the body’s serotonin, a key neurotransmitter that regulates mood, sleep, and cognition.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
June 27, 2016
/
Autoimmune Diseases
•
Autoimmune Diseases
Did you know?
Americans are over three times more likely to suffer from autoimmune diseases compared to the global average, with approximately 16.67% of the U.S. population affected versus 5% worldwide.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Autism spectrum disorder (ASD)
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social, communication, and behavioral challenges. It involves genetic and environmental factors, including microbiome imbalances which influence symptom severity and overall health.
Microbiome-Targeted Interventions (MBTIs)
Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.
Autism spectrum disorder (ASD)
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social, communication, and behavioral challenges. It involves genetic and environmental factors, including microbiome imbalances which influence symptom severity and overall health.
Autism spectrum disorder (ASD)
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social, communication, and behavioral challenges. It involves genetic and environmental factors, including microbiome imbalances which influence symptom severity and overall health.