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Microbiome Signature 
Research Feed 
Update History 2025-02-04 06:42:12
Alzheimer\\\'s Dementia majorpublished
Alzheimer’s Dementia
Researched by:
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Kimberly Eyer
ID
Kimberly Eyer
Read MoreKimberly Eyer, a Registered Nurse with 30 years of nursing experience across diverse settings, including Home Health, ICU, Operating Room Nursing, and Research. Her roles have encompassed Operating Room Nurse, RN First Assistant, and Acting Director of a Same Day Surgery Center. Her specialty areas include Adult Cardiac Surgery, Congenital Cardiac Surgery, Vascular Surgery, and Neurosurgery.
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Karen Pendergrass
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Karen Pendergrass
Read MoreKaren Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
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Dr. Umar
ID
Dr. Umar
Read MoreClinical Pharmacist and Clinical Pharmacy Master’s candidate focused on antibiotic stewardship, AI-driven pharmacy practice, and research that strengthens safe and effective medication use. Experience spans digital health research with Bloomsbury Health (London), pharmacovigilance in patient support programs, and behavioral approaches to mental health care. Published work includes studies on antibiotic use and awareness, AI applications in medicine, postpartum depression management, and patient safety reporting. Developer of an AI-based clinical decision support system designed to enhance antimicrobial stewardship and optimize therapeutic outcomes.
Fact-checked by:
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Kimberly Eyer
ID
Kimberly Eyer
Read More
Alzheimer’s disease (D) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, and metabolic dysfunction, ultimately leading to cognitive decline and dementia. Emerging research highlights the microbiota-gut-brain axis as a crucial factor in D pathogenesis, with gut dysbiosis contributing to neuroinflammation, immune dysregulation, and blood-brain barrier permeability. Microbial metabolites, such as […]
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Kimberly Eyer
Read More -
Karen Pendergrass
Read More -
Dr. Umar
Read More
Researched by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read More -
Karen Pendergrass
ID
Karen Pendergrass
Read More -
Dr. Umar
ID
Dr. Umar
Read More
Fact-checked by:
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Kimberly Eyer
ID
Kimberly Eyer
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Microbiome Signatures
Overview
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, and metabolic dysfunction, ultimately leading to cognitive decline and dementia. Emerging research highlights the microbiota-gut-brain axis as a crucial factor in AD pathogenesis, with gut dysbiosis contributing to neuroinflammation, immune dysregulation, and blood-brain barrier permeability. Microbial metabolites, such as short-chain fatty acids and amyloid-like proteins, can influence neurodegeneration, either exacerbating or mitigating disease progression. These findings position the microbiome as a key target for potential interventions, including dietary modifications, probiotics, and fecal microbiota transplantation (FMT), while salivary microbiome analysis presents a promising avenue for non-invasive AD diagnostics. Understanding and standardizing microbiome signatures may provide critical insights into disease mechanisms and open new pathways for early detection and therapeutic strategies.
Microbiome Signature: Alzheimer’s Dementia
Research Feed
Nickel chelator dimethylglyoxime inhibits amyloid beta aggregation in vitro and targets nickel-driven Alzheimer’s mechanisms
Dimethylglyoxime (DMG) •
Dimethylglyoxime (DMG)
Dimethylglyoxime (DMG) is a nickel chelator with potential as an antimicrobial agent by inhibiting nickel-dependent enzymes in pathogens, offering novel therapeutic applications and strategies to combat bacterial, fungal, and protozoal infections, while addressing antibiotic resistance concerns.
Nickel •
Nickel
Did you know?
Nickel is essential for the virulence of many pathogens, but not a single human enzyme requires it. This makes nickel metabolism a unique microbial vulnerability and a promising antimicrobial target.
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Metallomic signatures of brain tissues distinguishes between cases of dementia with Lewy bodies, Alzheimer’s disease, and Parkinson’s disease dementia
June 26, 2024
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Metallomic Signatures •
Metallomic Signatures
Did you know?
Metallomic signatures can reveal hidden drivers of disease by mapping how trace metals like nickel, iron, and cadmium shape microbial behavior and immune responses. These signatures not only help identify toxic exposures but also spotlight metal-dependent pathogens, offering new targets for precision-guided therapies.
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Neuromicrobiology, an Emerging Neurometabolic Facet of the Gut Microbiome?
January 17, 2023
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Brain Health •
Brain Health
Did you know?
The gut microbiome produces over 90% of the body’s serotonin, a key neurotransmitter that regulates mood, sleep, and cognition.
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Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway
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APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer Disease
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Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort
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Analysis of Salivary Microbiome in Patients with Alzheimer’s Disease
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Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
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Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease
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Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment
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Gut Microbiota is Altered in Patients with Alzheimer’s Disease
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Gut microbiome alterations in Alzheimer’s disease
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Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
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Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota
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Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease
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Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota
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Modulation of the Gut Microbiota in Memory Impairment and Alzheimer’s Disease via the Inhibition of the Parasympathetic Nervous System
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Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer’s disease
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Update History
Dimethylglyoxime (DMG)
Dimethylglyoxime represents a novel therapeutic paradigm that exploits a fundamental metabolic difference between pathogenic bacteria and their mammalian hosts. By selectively depleting bacterial access to nickel, a cofactor essential for multiple pathogenic enzymes but unnecessary for human physiology, DMG offers a theoretically host-sparing antimicrobial approach.
Nickel
Bacteria regulate transition metal levels through complex mechanisms to ensure survival and adaptability, influencing both their physiology and the development of antimicrobial strategies.
Metallomic Signatures
A metallomic signature is the condition-specific profile of trace metals and metal-binding molecules that reflects disrupted metal homeostasis.
Brain Health
Brain health encompasses the overall functioning and well-being of the brain, including cognitive function, emotional and psychological well-being, neurological integrity, behavioral health, neurodevelopmental health, age-related brain health, and brain resilience and plasticity.