Hashimoto’s Thyroiditis
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Karen Pendergrass
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Karen Pendergrass
Read MoreKaren Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
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Kimberly Eyer
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Kimberly Eyer
Read MoreKimberly Eyer, a Registered Nurse with 30 years of nursing experience across diverse settings, including Home Health, ICU, Operating Room Nursing, and Research. Her roles have encompassed Operating Room Nurse, RN First Assistant, and Acting Director of a Same Day Surgery Center. Her specialty areas include Adult Cardiac Surgery, Congenital Cardiac Surgery, Vascular Surgery, and Neurosurgery.
Hashimoto’s Thyroiditis (T) is an autoimmune disorder characterized by the progressive destruction of thyroid follicles due to chronic inflammation, often leading to hypothyroidism. It affects 10-12% of the global population, with a significantly higher prevalence among women. While its etiology involves genetic, environmental, and epigenetic factors, increasing evidence highlights the role of gut microbiota in […]
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Karen Pendergrass
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Kimberly Eyer
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Researched by:
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Karen Pendergrass
ID
Karen Pendergrass
Read More -
Kimberly Eyer
ID
Kimberly Eyer
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
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Hashimoto’s Thyroiditis (HT) is an autoimmune disorder characterized by the progressive destruction of thyroid follicles due to chronic inflammation, often leading to hypothyroidism. It affects 10-12% of the global population, with a significantly higher prevalence among women. While its etiology involves genetic, environmental, and epigenetic factors, increasing evidence highlights the role of gut microbiota in its pathogenesis. [1][2][3][4]
What role do metals play in Hashimoto's thyroiditis?
What role do metals play in Hashimoto's thyroiditis?
Heavy metals like nickel (Ni), arsenic (As), and lead (Pb) are frequently elevated in HT patients and are linked to thyroid dysfunction. These metals interfere with thyroid hormone synthesis, selenium (Se) metabolism, and antioxidant defense, exacerbating oxidative stress and autoimmune responses.
Which metals are associated with Hashimoto's thyroiditis?
Which metals are associated with Hashimoto's thyroiditis?
Nickel (Ni), arsenic (As), and lead (Pb) are elevated in HT patients and can disrupt thyroid hormone synthesis and selenium (Se) metabolism, worsening thyroid inflammation.
Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
Significance of arsenic and lead in Hashimoto’s thyroiditis demonstrated on T thyroid tissue, blood, and urine samples
How does selenium deficiency affect the thyroid in HT?
How does selenium deficiency affect the thyroid in HT?
Selenium is essential for thyroid hormone synthesis and antioxidant defense. Deficiency, often caused by heavy metal interference, can exacerbate thyroid tissue damage.
Significance of arsenic and lead in Hashimoto’s thyroiditis demonstrated on T thyroid tissue, blood, and urine samples
Are there ways to mitigate the effects of toxic metals in HT?
Are there ways to mitigate the effects of toxic metals in HT?
Yes, dietary interventions, chelation therapies, and prebiotic and probiotic supplementation are potential strategies to reduce toxic metal burden and improve thyroid health.
Significance of arsenic and lead in Hashimoto’s thyroiditis demonstrated on T thyroid tissue, blood, and urine samples
How is Hashimoto's thyroiditis related to the gut microbiome?
How is Hashimoto's thyroiditis related to the gut microbiome?
Hashimoto’s thyroiditis (HT) is closely tied to the gut microbiome through the “gut-thyroid axis,” a bidirectional relationship between the gut and thyroid. Studies have shown that gut dysbiosis—a disruption in the balance of gut microbes—can trigger or exacerbate autoimmune reactions in HT. Altered microbial diversity in HT patients includes reduced beneficial bacteria like Fecalibacterium and Prevotella, and increased harmful species like Escherichia-Shigella and Parasutterella. These changes can promote inflammation and immune dysregulation, contributing to thyroid tissue damage. Conversely, thyroid dysfunction can also impair gut motility and alter microbial composition.
Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto’s thyroiditis.
Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients.
Research Feed
Alterations of the Gut Microbiota in Hashimoto’s Thyroiditis Patients
February 1, 2018
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Autoimmune Diseases •
Autoimmune Diseases
Did you know?
Americans are over three times more likely to suffer from autoimmune diseases compared to the global average, with approximately 16.67% of the U.S. population affected versus 5% worldwide.
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Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto’s thyroiditis
November 20, 2024
/
Autoimmune Diseases •
Autoimmune Diseases
Did you know?
Americans are over three times more likely to suffer from autoimmune diseases compared to the global average, with approximately 16.67% of the U.S. population affected versus 5% worldwide.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients
September 10, 2017
/
Autoimmune Diseases •
Autoimmune Diseases
Did you know?
Americans are over three times more likely to suffer from autoimmune diseases compared to the global average, with approximately 16.67% of the U.S. population affected versus 5% worldwide.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants.
January 3, 2024
/
Autoimmune Diseases •
Autoimmune Diseases
Did you know?
Americans are over three times more likely to suffer from autoimmune diseases compared to the global average, with approximately 16.67% of the U.S. population affected versus 5% worldwide.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
References
- Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto's thyroiditis.. Li, M., Chen, K., Chen, Y. et al. Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto's thyroiditis.. (J Transl Med, 2024.)
- Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients.. Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, Jin Y, Zhu B, Wei Y.. (Thyroid. 2018)
- Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients.. Ishaq HM, Mohammad IS, Guo H, Shahzad M, Hou YJ, Ma C, Naseem Z, Wu X, Shi P, Xu J.. (Biomed Pharmacother. 2017)
- Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants.. Fenneman AC, Boulund U, Collard D, Galenkamp H, Zwinderman AH, van den Born BH, van der Spek AH, Fliers E, Rampanelli E, Blaser MJ, Nieuwdorp M.. (Thyroid. 2024)
Li, M., Chen, K., Chen, Y. et al. Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto's thyroiditis.
Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto's thyroiditis.J Transl Med, 2024.
Read ReviewZhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, Jin Y, Zhu B, Wei Y.
Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients.Thyroid. 2018
Read ReviewIshaq HM, Mohammad IS, Guo H, Shahzad M, Hou YJ, Ma C, Naseem Z, Wu X, Shi P, Xu J.
Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients.Biomed Pharmacother. 2017
Read ReviewFenneman AC, Boulund U, Collard D, Galenkamp H, Zwinderman AH, van den Born BH, van der Spek AH, Fliers E, Rampanelli E, Blaser MJ, Nieuwdorp M.
Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants.Thyroid. 2024
Read Review