Irritable Bowel Syndrome (IBS)
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Karen Pendergrass
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Karen Pendergrass
Read MoreKaren Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
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Kimberly Eyer
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Kimberly Eyer
Read MoreKimberly Eyer, a Registered Nurse with 30 years of nursing experience across diverse settings, including Home Health, ICU, Operating Room Nursing, and Research. Her roles have encompassed Operating Room Nurse, RN First Assistant, and Acting Director of a Same Day Surgery Center. Her specialty areas include Adult Cardiac Surgery, Congenital Cardiac Surgery, Vascular Surgery, and Neurosurgery.
Irritable Bowel Syndrome (BS) is a common gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits. Recent research has focused on the gut microbiota’s role in BS, aiming to identify specific microbial signatures associated with the condition.
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Researched by:
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Karen Pendergrass
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Karen Pendergrass
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Kimberly Eyer
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Kimberly Eyer
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Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Karen Pendergrass
Overview 
Microbiome Signature 
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References Overview
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits. Recent research has focused on the gut microbiota’s role in IBS, aiming to identify specific microbial signatures associated with the condition.
Key Insights
Altered Microbial Composition in IBS Patients:
Increased levels of Enterobacteriaceae, Lactobacillaceae, and Bacteroides; decreased levels of uncultured Clostridiales I, Faecalibacterium (including Faecalibacterium prausnitzii), and Bifidobacterium in IBS patients compared to healthy controls. [x] [x] [x] Increased Firmicutes, decreased Bacteroidetes, and a higher Firmicutes: Bacteroidetes ratio in IBS patients [x] and higher levels of Escherichia coli and Enterobacter, and lower levels of Lactobacillus and Bifidobacterium in IBS patients [4][x].
Pediatric Irritable Bowel
Increased abundance of γ-proteobacteria, particularly Haemophilus parainfluenzae, in pediatric IBS patients, a novel Ruminococcus-like microbe associated with IBS, and Increased abundance of several bacterial taxa from the genus Alistipes correlated with a greater frequency of pain in pediatric IBS patients [5]
Microbial Signatures and IBS Severity:
A specific microbial signature consisting of 90 bacterial operational taxonomic units (OTUs) associated with severe IBS symptoms. IBS symptom severity negatively associated with microbial richness, exhaled CH4, presence of methanogens, and enterotypes enriched with Clostridiales or Prevotella species. [6]
Metal Homeostasis in IBS
High serum copper levels are associated with a lower risk of developing IBS, suggesting a protective role of copper in IBS [7]
Individuals with IBS have higher copper–zinc ratios, suggesting a potential copper–zinc imbalance that may contribute to the underlying pathophysiology of IBS. [8]
Microbiome Signature: Irritable Bowel Syndrome (IBS)
Research Feed
Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome
August 20, 2019
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Irritable Bowel Syndrome and Nickel Allergy:What Is the Role of the Low Nickel Diet?
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Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome
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Gut microbiome signatures reflect different subtypes of irritable bowel syndrome
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Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes
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Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data
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Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome
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More than constipation – bowel symptoms in Parkinson’s disease and their connection to gut microbiota
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The microbiome of the oral mucosa in irritable bowel syndrome
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Fecal Microbiota in Patients with Irritable Bowel Syndrome Compared with Healthy Controls Using Real-Time Polymerase Chain Reaction: An Evidence of Dysbiosis
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Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
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Zinc
Zinc is an essential trace element vital for cellular functions and microbiome health. It influences immune regulation, pathogen virulence, and disease progression in conditions like IBS and breast cancer. Pathogens exploit zinc for survival, while therapeutic zinc chelation can suppress virulence, rebalance the microbiome, and offer potential treatments for inflammatory and degenerative diseases.
References
- Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review.. Pittayanon, R., Lau, J., Yuan, Y., Leontiadis, G., Tse, F., Surette, M., & Moayyedi, P.. (Gastroenterology. 2019)
- Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies.. Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G.. (Journal of the Academy of Nutrition and Dietetics. (2020))
- Alterations of Gut Microbiota in Patients With Irritable Bowel Syndrome Based on 16S rRNA-Targeted Sequencing: A Systematic Review.. Duan, R., Zhu, S., Wang, B., & Duan, L.. (Gastroenterology. (2019))
- Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies.. Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G.. (Journal of the Academy of Nutrition and Dietetics. (2020))
- Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome.. Saulnier, D., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E., Qin, X., Coarfa, C., Milosavljevic, A., Petrosino, J., Highlander, S., Gibbs, R., Lynch, S., Shulman, R., & Versalovic, J.. (Gastroenterology, 2011.)
- dentification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome.. Tap, J., Derrien, M., Törnblom, H., Brazeilles, R., Cools-Portier, S., Doré, J., Störsrud, S., Nevé, B., Öhman, L., & Simrén, M.. (Gastroenterology, 2017.)
- The Role of Copper and Zinc in Irritable Bowel Syndrome: A Mendelian Randomization Study.. Hujoel, I., & Hujoel, M.. (American journal of epidemiology. (2021))
- Nutritional status in irritable bowel syndrome: A North American population‐based study.. Hujoel, I.. (JGH Open: An Open Access Journal of Gastroenterology and Hepatology. 2020)
Pittayanon, R., Lau, J., Yuan, Y., Leontiadis, G., Tse, F., Surette, M., & Moayyedi, P.
Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review.Gastroenterology. 2019
Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G.
Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies.Journal of the Academy of Nutrition and Dietetics. (2020)
Duan, R., Zhu, S., Wang, B., & Duan, L.
Alterations of Gut Microbiota in Patients With Irritable Bowel Syndrome Based on 16S rRNA-Targeted Sequencing: A Systematic Review.Gastroenterology. (2019)
Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G.
Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies.Journal of the Academy of Nutrition and Dietetics. (2020)
Saulnier, D., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E., Qin, X., Coarfa, C., Milosavljevic, A., Petrosino, J., Highlander, S., Gibbs, R., Lynch, S., Shulman, R., & Versalovic, J.
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome.Gastroenterology, 2011.
Tap, J., Derrien, M., Törnblom, H., Brazeilles, R., Cools-Portier, S., Doré, J., Störsrud, S., Nevé, B., Öhman, L., & Simrén, M.
dentification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome.Gastroenterology, 2017.
Hujoel, I., & Hujoel, M.
The Role of Copper and Zinc in Irritable Bowel Syndrome: A Mendelian Randomization Study.American journal of epidemiology. (2021)
Hujoel, I.
Nutritional status in irritable bowel syndrome: A North American population‐based study.JGH Open: An Open Access Journal of Gastroenterology and Hepatology. 2020