Müllerianosis theory posits that embryonic Müllerian duct remnants misplace and differentiate, forming endometrial-like tissues in non-uterine locations post-puberty, contributing to conditions like endometriosis.
Müllerianosis theory
Researched by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read MoreKimberly Eyer, a Registered Nurse with 30 years of nursing experience across diverse settings, including Home Health, ICU, Operating Room Nursing, and Research. Her roles have encompassed Operating Room Nurse, RN First Assistant, and Acting Director of a Same Day Surgery Center. Her specialty areas include Adult Cardiac Surgery, Congenital Cardiac Surgery, Vascular Surgery, and Neurosurgery.
Fact-checked by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read More
Müllerianosis theory posits that embryonic Müllerian duct remnants misplace and differentiate, forming endometrial-like tissues in non-uterine locations post-puberty, contributing to conditions like endometriosis.
Research feed -
Karen Pendergrass
Read MoreKaren Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
-
Kimberly Eyer
Read More
Researched by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read More
Fact-checked by:
-
Kimberly Eyer
ID
Kimberly Eyer
Read More
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Karen Pendergrass
Overview 
Research Feed Overview
Müllerianosis theory explains the development of benign ectopic lesions like endometriosis, adenomyosis, and endosalpingiosis, which involve endometrium-like tissues outside the uterus. Müllerianosis theory suggests that during fetal development, cells from the Müllerian ducts can become displaced or left behind, ending up in various parts of the pelvic and abdominal cavities. The displaced Müllerian tissue remains dormant until puberty, when hormonal changes activate these cells, causing them to proliferate and form lesions typical of conditions like endometriosis. This theory posits that ectopic Müllerian tissues can differentiate into structures resembling parts of the uterus, such as the endometrial glands and stroma (endometriosis), the muscle layer (adenomyosis), or the fallopian tubes (endosalpingiosis). [x] This theory provides a crucial framework for understanding and researching these reproductive conditions, manifesting as misplaced tissues mature in adulthood.
Limitations
While Müllerianosis offers a compelling explanation, it is not without its limitations. There is ongoing debate regarding the precise origins of endometriosis and related conditions. Some researchers argue for alternative theories, such as retrograde menstruation, coelomic metaplasia, and lymphovascular metastasis theory. The Müllerianosis theory does not fully explain why only some develop conditions like endometriosis if all women have Müllerian remnants. This suggests that other factors, like the microbiome, play significant roles.
Research Feed
Müllerian duct anomalies coincident with endometriosis: a review
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Coincidence of uterine malformations and endometriosis: a clinically relevant problem?
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Insiders can read two study summaries for any topic on Microbiome.
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
Retrograde Menstruation Theory
Retrograde menstruation theory holds that during menstruation, some endometrial tissue reverses through the fallopian tubes into the pelvic cavity. It implants on pelvic organs, thickens, breaks down, and bleeds cyclically, causing inflammation, pain, and scar tissue, characteristic of endometriosis.
Coelomic Metaplasia Theory
Coelomic Metaplasia Theory could help explain the cases of endometriosis in men or in women who are not yet menstruating.
Lymphovascular Metastasis Theory
Lymphovascular Metastasis Theory posits that endometrial cells spread via blood and lymph systems, causing distant endometriosis. Evidence is promising but limited.