Does Exposure of Lead and Cadmium Affect the Endometriosis? Original paper
Researched by:
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Karen Pendergrass
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Karen Pendergrass
Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
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Karen Pendergrass
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Karen Pendergrass
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Metals
Metals
OverviewHeavy metals play a significant and multifaceted role in the pathogenicity of microbial species. Their involvement can be viewed from two primary perspectives: the toxicity of heavy metals to microbes and the exploitation of heavy metals by microbial pathogens to establish infections and evade the host immune response. Understanding these aspects is critical for both […]
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Endometriosis
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
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Karen Pendergrass
Researched by:
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Karen Pendergrass
ID
Karen Pendergrass
Fact-checked by:
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Karen Pendergrass
ID
Karen Pendergrass
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Karen Pendergrass
What Was Studied?
This study investigated the association between occupational exposure to lead and cadmium and the risk of developing endometriosis (EM) among South Korean female workers. Utilizing medical and biological data from over 26,000 individuals who underwent lead-associated medical examinations between 2000 and 2004, the study examined blood lead levels (BLLs), co-exposure to cadmium, and their relationship with hospital admissions for EM.
Who Was Studied?
The study focused on South Korean female workers exposed to lead as part of their occupation. These individuals underwent specialized medical examinations. A total of 26,542 workers were included, with the study comparing EM admissions in lead-exposed workers against the general population and noise-exposed workers as control groups.
What Were the Most Important Findings?
The study found that lead exposure, even at relatively low levels (BLLs <5 µg dl), was significantly associated with an increased risk of em. the standard admission rate (sar) for em in lead-exposed workers 1.24 times higher than general population, and blls < 5 dl, it 1.44 higher. co-exposure to lead cadmium demonstrated a synergistic effect, amplifying beyond what could be expected from exposure either metal alone. while alone did not show statistically significant association em, relative excess due interaction (reri) 0.33, indicating notable combined impact these metals. study also highlighted that oxidative stress induced by heavy likely underpins effects, mechanisms involving disruption antioxidant defenses cellular damage.< p>
What Are the Greatest Implications of This Study?
This research underscores the need to minimize exposure to heavy metals, particularly lead and cadmium, among female workers. It also calls for rigorous monitoring of blood lead and cadmium levels in workplaces to mitigate their combined effects. The findings are critical for understanding the environmental and occupational contributors to EM and suggest that policies limiting heavy metal exposure could have a substantial public health impact, especially for at-risk populations.
Endometriosis
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.