The effect of resistant dextrin as a prebiotic on metabolic parameters and androgen level in women with polycystic ovarian syndrome Original paper
Researched by:
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Divine Aleru
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Divine Aleru
I am a biochemist with a deep curiosity for the human microbiome and how it shapes human health, and I enjoy making microbiome science more accessible through research and writing. With 2 years experience in microbiome research, I have curated microbiome studies, analyzed microbial signatures, and now focus on interventions as a Microbiome Signatures and Interventions Research Coordinator.
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Women’s Health
Women’s Health
Women’s health, a vital aspect of medical science, encompasses various conditions unique to women’s physiological makeup. Historically, women were often excluded from clinical research, leading to a gap in understanding the intricacies of women’s health needs. However, recent advancements have highlighted the significant role that the microbiome plays in these conditions, offering new insights and potential therapies. MicrobiomeSignatures.com is at the forefront of exploring the microbiome signature of each of these conditions to unravel the etiology of these diseases and develop targeted microbiome therapies.
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Divine Aleru
Researched by:
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Divine Aleru
ID
Divine Aleru
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Divine Aleru
What Was Studied?
This study investigated the effects of resistant dextrin, a type of prebiotic, on metabolic parameters and androgen levels in women with polycystic ovary syndrome (PCOS). The goal was to determine if resistant dextrin could improve parameters such as lipid profiles, fasting blood glucose (FBS), high-sensitivity C-reactive protein (hsCRP), and levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone, which are associated with androgen excess in PCOS. Additionally, the study explored the impact on clinical manifestations such as menstrual cycle irregularities and hirsutism.
Who Was Studied?
The study involved 62 women diagnosed with PCOS based on the Rotterdam criteria. These participants were randomly divided into a prebiotic group, which consumed 20 grams of resistant dextrin daily, and a placebo group, which consumed an equal amount of maltodextrin. Both groups were observed for three months. The participants were assessed for various metabolic and endocrine parameters, including lipid profiles, blood glucose, hsCRP, DHEA-S, free testosterone, and clinical signs such as hirsutism and menstrual cycle irregularities.
What Were the Most Important Findings?
The study found that, after three months, the prebiotic group experienced significant improvements in several metabolic and endocrine parameters. Specifically, resistant dextrin supplementation led to reductions in LDL-cholesterol, triglycerides, total cholesterol, fasting blood glucose, hsCRP, DHEA-S, and free testosterone. Additionally, HDL-cholesterol levels increased significantly in the prebiotic group compared to the placebo group. The prebiotic group also saw improvements in clinical manifestations of PCOS, including a reduction in the hirsutism score and more regular menstrual cycles.
From a microbiome perspective, the findings are particularly relevant. The consumption of resistant dextrin, a prebiotic fiber, is known to modulate the gut microbiota, potentially increasing beneficial bacteria like Bifidobacterium and Lactobacillus. These bacteria play a crucial role in regulating systemic inflammation and metabolic function, which may explain the improvements observed in this study. Furthermore, the increased production of short-chain fatty acids (SCFAs) due to prebiotic fermentation could enhance insulin sensitivity and reduce inflammation, which are key factors in PCOS pathology.
What Are the Greatest Implications of This Study?
This study underscores the potential of resistant dextrin as a therapeutic intervention for improving metabolic and hormonal imbalances in women with PCOS. Given the lack of effective treatments that address both metabolic and endocrine dysfunction in PCOS, the use of prebiotics offers a promising alternative to pharmacological treatments, which often come with side effects. By modulating the gut microbiota, prebiotics may not only improve lipid profiles and insulin resistance but also address clinical symptoms such as hirsutism and menstrual irregularity. This study suggests that dietary interventions using prebiotics like resistant dextrin could be integrated into the management of PCOS, offering a low-cost, side-effect-free alternative to more invasive treatments.
Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and insulin resistance. It is often associated with metabolic dysfunctions and inflammation, leading to fertility issues and increased risk of type 2 diabetes and cardiovascular disease.