Did you know?
Research suggests that compounds in kudzu might decrease alcohol intake by increasing alcohol’s effects on the brain, leading to quicker feelings of intoxication.
Pueraria Flower Extract (PFE)
Pueraria lobata (kudzu) is used in traditional medicine for cardiovascular issues, menopause, and alcohol dependence due to its bioactive isoflavones. These compounds, particularly puerarin, offer vasodilatory effects and antioxidant properties, enhancing blood circulation and reducing oxidative stress.
-
Karen Pendergrass
Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease—four years before the first published case study.
Microbiome Signatures identifies and validates condition-specific microbiome shifts and interventions to accelerate clinical translation. Our multidisciplinary team supports clinicians, researchers, and innovators in turning microbiome science into actionable medicine.
Overview
Pueraria Flower Extract (PFE) is a concentrated extract obtained from the flowers of Pueraria lobata. It is rich in bioactive compounds, particularly isoflavones such as tectoridin, tectorigenin, and puerarin, which are known for their antioxidant, anti-inflammatory, hepatoprotective, and hormone-modulating effects.
Pueraria Flower Extract (PFE) as a Microbiome-Targeted Intervention
This Microbiome-Targeted Interventions (MBTI) section outlines the conditions for which Pueraria Flower Extract (PFE) has been investigated, as well as its current validation status for those conditions. Due to the newness of this database, many conditions are not currently listed for which PFE may be validated.
Condition | ValidationStatus |
---|---|
Endometriosis | Valid |
Obesity | – |
Mechanisms of action
The mechanism of action of Pueraria Flower Extract includes modulation of metabolic pathways, inhibition of matrix metalloproteinase (MMP), and suppression of cell adhesion and migration, primarily driven by its isoflavone content. These mechanisms allow its application in managing obesity, endometriosis, and possibly other metabolic and inflammatory conditions. PFE’s bioactive properties make it a candidate for treating or managing conditions like endometriosis, obesity [1] , and cognitive impairments.
Research Feed
Did you know?
Gut microbiota predict endometriosis better than vaginal microbiota.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Alias iure reprehenderit aut accusantium. Molestiae dolore suscipit. Necessitatibus eum quaerat. Repudiandae suscipit quo necessitatibus. Voluptatibus ullam nulla temporibus nobis. Atque eaque sed totam est assumenda. Porro modi soluta consequuntur veritatis excepturi minus delectus reprehenderit est. Eveniet labore ut quas minima aliquid quibusdam. Vitae possimus fuga praesentium eveniet debitis exercitationem deleniti.
Create a free account to unlock this study summary.
Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
Pueraria Flower Extract (PFE) addresses microbial imbalances and inflammation in endometriosis, validating its role as a microbiome-targeted therapy.
Matrix Metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix remodeling, with critical roles in health, disease, and interactions with the microbiome.
Endometriosis involves ectopic endometrial tissue causing pain and infertility. Validated and Promising Interventions include Hyperbaric Oxygen Therapy (HBOT), Low Nickel Diet, and Metronidazole therapy.
References
- Consumption of Pueraria Flower Extract Reduces Body Mass Index via a Decrease in the Visceral Fat Area in Obese Humans. Tomoyasu KAMIYA, Akira TAKANO, Yuki MATSUZUKA, Nobutaka KUSABA, Motoya IKEGUCHI, Kinya TAKAGAKI, Kazuo KONDO,. (Bioscience, Biotechnology, and Biochemistry. August 23, 2012)
Tomoyasu KAMIYA, Akira TAKANO, Yuki MATSUZUKA, Nobutaka KUSABA, Motoya IKEGUCHI, Kinya TAKAGAKI, Kazuo KONDO,
Consumption of Pueraria Flower Extract Reduces Body Mass Index via a Decrease in the Visceral Fat Area in Obese HumansBioscience, Biotechnology, and Biochemistry. August 23, 2012
Read Review